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Agostini, Matteo

Publications and source records attributed to Agostini, Matteo.

Toward the discovery of matter creation with neutrinoless β β decay

The discovery of neutrinoless ββ decay could soon be within reach. This hypothetical ultrarare nuclear decay offers a privileged portal to physics beyond the standard model of particle physics. Its observation would constitute the discovery of a matter-creating process, corroborating leading theories of why the Universe contains more matter than antimatter, and how forces unify at high energy scales. It would also prove that neutrinos and antineutrinos are not two distinct particles but can transform into each other, with their mass described by a unique mechanism conceived by Majorana. The recognition that neutrinos are not massless necessitates an explanation and has boosted interest in neutrinoless ββ decay. The field stands now at a turning point. Further, a new round of experiments is currently being prepared for the next decade to cover an important region of parameter space. In parallel, advances in nuclear theory are laying the groundwork to connect the nuclear decay with the underlying new physics. Meanwhile, the particle theory landscape continues to find new motivations for neutrinos to be their own antiparticle. This review brings together the experimental, nuclear theory, and particle theory aspects connected to neutrinoless ββ decay to explore the path toward, and beyond, its discovery.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Tuning gold-based surface functionalization for streptavidin detection: A combined simulative and experimental study

A rationally designed gold-functionalized surface capable of capturing a target protein is presented using the biotin–streptavidin pair as a proof-of-concept. We carried out multiscale simulations to shed light on the binding mechanism of streptavidin on four differently biotinylated surfaces. Brownian Dynamics simulations were used to reveal the preferred initial orientation of streptavidin over the surfaces, whereas classical molecular dynamics was used to refine the binding poses and to investigate the fundamental forces involved in binding, and the binding kinetics. We assessed the binding events and the stability of the streptavidin attachment through a quartz crystal microbalance with dissipation monitoring (QCM-D). The sensing element comprises of biotinylated polyethylene glycol chains grafted on the sensor’s gold surface via thiol-Au chemistry. Finally, we compared the results from experiments and simulations. We found that the confined biotin moieties can specifically capture streptavidin from the liquid phase and provide guidelines on how to exploit the microscopic parameters obtained from simulations to guide the design of further biosensors with enhanced sensitivity.

59 BASIC BIOLOGICAL SCIENCES↗