Frequency distributions of energy deposition by 44 MeV protons at bone-soft tissue interfaces
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Engineering topics
Publications and source records attributed to Baily, N. A..
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The radiological implications of statistical variations in energy deposition by ionizing radiation were investigated in the conduct of the following experiments: (1) study of the production of secondary particles generated by the passage of the primary radiation through bone and muscle; (2) the study of the ratio of nonreparable to reparable damage in DNA as a function of different energy deposition patterns generated by X rays versus heavy fast charged particles; (3) the use of electronic radiography systems for direct fluoroscopic tomography and for the synthesis of multiple planes and; (4) the determination of the characteristics of systems response to split fields having different contrast levels, and of minimum detectable contrast levels between the halves under realistic clinical situations.
The authors describe a fluoroplanigraphic method of synthesizing single-plane sections of any desired layer within the body. This is done by appropriate positioning of the individual images obtained at various locations of the X-ray tube during a single tomographic motion, followed by electronic summation of each roentgenogram. A TV image of any desired body section is available within seconds of the original recording sequence.
The experimental approach considered requires the measurement of energy-absorption distributions for a set of pathlengths which define a biological volume. A suitable folding procedure is necessary to produce composite energy-absorption distributions. The investigation is concerned with the quality of the prediction of energy-deposition distributions, taking into account distributions measured with a proportional counter.
Serious consideration of the physics of energy deposition indicates that a fundamental change in the interpretation of absorbed dose is required at least for considerations of effects in biological systems. In addition, theoretical approaches to radiobiology and microdosimetry seem to require statistical considerations incorporating frequency distributions of the magnitude of the event sizes within the volume of interest.
The frequency distributions of event size in the deposition of energy over small pathlengths have been measured after penetration of 44.3 MeV protons through various thicknesses of tissue-equivalent material. Results show that particle energy straggling of an initially monoenergetic proton beam after passage through an absorber causes the frequency distributions of energy deposited in short pathlengths of low atomic number materials to remain broad. In all cases investigated, the ratio of the most probable to the average energy losses has been significantly less than unity.
A single scan TV-radiography system capable of providing analogue signals ready for A-D conversion for input to a computer has been investigated. Modulation transfer functions of both horizontal and vertical resolution have been obtained. The capability for gray scale reproduction was also investigated. The output data rate of the system is 16 KHz thereby providing compatibility to A-D converters generally available for most computers. In general, the capability of the system was found to exceed the input capabilities of available image-amplifiers and is therefore acceptable for quantitative fluoroscopic applications.
Frequency distributions of event size in deposition of energy over small pathlengths measured after penetration of 44.3 MeV protons through thicknesses of tissue-like material
Investigating experimental and theoretical approaches to microdosimetry, radiobiology, and single-scan television systems
Energy losses frequency distributions for fast charged particles in small pathlengths in equimolar He-carbon dioxide mixture
Space radiation hazards and proton energy deposition in man
Cyclotron radiation experiments to test Blunck-Leisegang theory of statistical distributions of small energy losses for pathlengths of biological interest
Frequency distribution of energy losses in He- carbon dioxide mixture by 43.7 Mev protons, using proportional counter technique
Isodose patterns, microdosimetric distributions, and energy event frequency distributions in relation to radiobiological hazards in space
Microscopic energy deposition from passing protons in tissue sphere
Energy deposition by monoenergetic unidirectional proton beams incident on polystyrene phantom, obtaining centerline depth dose curves
Magnetic field quenching of enhanced pulses produced in silicon nuclear particle detectors upon irradiation by light particles and low energy gamma rays
Observation of nuclear pulse height increases in silicon p-n junction radiation detectors