Engineering topics

Barnes, P. R.

Publications and source records attributed to Barnes, P. R..

16 records

NASA NTRS1999

Exercise Training During +Gz Acceleration

The overall purpose is to study the effect of passive (without exercise) and active (with exercise) +Gz (head-to-foot) acceleration training, using a short-arm (1.9m radius) centrifuge, on post- training maximal oxygen uptake (VO2 max, work capacity) and 70 deg head-up tilt (orthostatic) tolerance in ambulatory subjects to test the hypothesis that (a) both passive and active acceleration training will improve post-training tilt-tolerance, and (b) there will be no difference in tilt-tolerance between passive and active exercise acceleration training because increased hydrostatic and blood pressures, rather than increased muscular metabolism, will provide the major adaptive stimulus. The purpose of the pilot study was to test the hypothesis that there would be no significant difference in the metabolic responses (oxygen uptake, heart rate, pulmonary ventilation, or respiratory exchange ratio) during supine exercise with moderate +Gz acceleration.

Greenleaf, J. E.↗

NASA NTRS1999

Leucocytosis, Thrombocytosis, and Plasma Osmolality During Rest and Exercise: A Hypothesis

The mechanism for inducing leucocytosis (increase in white blood cells) and thrombocytosis (increase in platelets) during exercise is unclear. Because plasma osmolality (Osm) may influence T-cell proliferation, Osm and the number of leucocytes (WBC) and platelets in blood were measured periodically during a 90 min rest period, and were compared with those during upright sitting ergometer exercise in six unt.rained, healthy men who cycled for 70 min at 71% of their maximal oxygen uptake (V prime O(sub 2(sub max)). There were 6 experiments in which the subjects drank different fluid formula-t4ilons (10 ml/kg) of various ionic and osmotic concentrations intermittently during 60 min of the rest period and during the exercise period. Osmolality, and WBC and platelet counts increased significantly (p<0.05) within the first 10 min of exercise, but the additional 60 min of exercise did not significantly change the leucocytosis or thrombocytosis. There were low but significant correlations between individual values of total WBC and total Osm during exercise (r(sub 0.001(2),284) = 0.39) and during rest plus exercise (r(sub 0.001(2),499) = 0.43). With combined data from the six experiments, mean Osm correlated highly and significantly with both mean WBC (r(sub 0.001(2),6) = 0.95, p < 0.001) and mean platelets (r(sub 0.001(2),6) = 0.94, p < 0.01) during the exercise phase. These data indicate that increases in leucocytes, thrombocytes, and osmolality occur primarily within the first 10 min of high-intensity exercise, but neither hypovolemia nor hyperthermia during exercise contributed to the leucocytosis, thrombocytosis, or hyperosmolality. The high correlations between plasma Osm and WBC or platelet counts suggest changes in osmolality may contribute to the mechanism of leucocytosis and thrombocytosis induced by exercise.

McKenzie, M. A.↗

NASA NTRS1998

Human Physiological Responses to Cycle Ergometer Leg Exercise During +Gz Acceleration

Spaceflight and bed-rest deconditioning decrease maximal oxygen uptake (aerobic power), strength, endurance capacity, and orthostatic tolerance. In addition to extensive use of muscular exercise conditioning as a countermeasure for the reduction in aerobic power (VO(sub 2max)), stimuli from some form of +Gz acceleration conditioning may be necessary to attenuate the orthostatic intolerance component of this deconditioning. Hypothesis: There will be no significant difference in the physiological responses (oxygen uptake, heart rate, ventilation, or respiratory exchange ratio) during supine exercise with moderate +Gz acceleration.

Chou, J. L.↗

NASA NTRS1997

Water Metabolism and Fluid Compartment Volumes in Humans at Altitude. A Compendium of Research (1914 - 1996)

This compendium includes abstracts and synopses of clinical observations and of more basic studies involving physiological mechanisms concerning interaction of water metabolism and fluid compartment volumes in humans during altitude exposure. If the author's abstract or summary was appropriate, it was included. In other cases a more detailed synopsis of the paper was prepared under the subheadings Purpose, Methods, Results, and Conclusions. Author and subject indices are provided, plus an additional selected bibliography of related work of those papers received after the volume was being prepared for publication. This volume includes material published from 1914 through 1995.

Chou, J. L.↗

NASA NTRS1997

Acceleration Tolerance: Effect of Exercise, Acceleration Training; Bed Rest and Weightlessness Deconditioning. A Compendium of Research (1950-1996)

This compendium includes abstracts and annotations of clinical observations and of more basic studies involving physiological mechanisms concerning interaction of acceleration, training and deconditioning. If the author's abstract or summary was appropriate, it was included. In other cases a more detailed annotation of the paper was prepared under the subheadings Purpose, Methods, Results, and Conclusions. Author and keyword indices are provided, plus an additional selected bibliography of related work and of those papers received after the volume was prepared for publication. This volume includes material published from 1950-1996.

Chou, J. L.↗

NASA NTRS1996

The Effect of Drinking on Plasma Vasopressin and Renin in Dehydrated Human Subjects

Oropharyngeal mechanisms activated by drinking have been shown to induce a rapid decline in plasma vasopressin which preceeds postabsorptive changes in plasma composition in the dehydrated dog. The present study was undertaken to determine what factor(s) inhibit(s) vasopressin secretion after rehydration in water deprived human subjects. Hematocrit (Hct) and hemoglobin (Hb) were determined on the day of the experiment, together with electrolytes and osmolalities which were measured on freshly separated serum. Plasma was immediately frozen and further analyzed by radioimmunoassay for renin activity (PRA), vasopressin (AVP), and aldosterone. The data were analyzed using an analysis of variance for repeated measurements and significant differences between the dehydrated control period and various time points after the start of rehydration were determined using a multiple-range test. began and reached water replete levels 15 minutes after drinking in the absence of any detectable decline in serum sodium or osmolality, we conclude that 427 oropharyngeal factors, alone or combined with gastric distension account for the extremely rapid inhibition of AVP secretion after drinking in the water-deprived human, as has been shown to be the case in dogs. Our findings are also in agreement wiht the recent demonstration that at the onset of drinking in the dehydrated monkey, there is an abrupt fall in plasma AVP concentration associated with a considerable decrease in the firing rate of the supraoptic neurosecretory neurons.

Geelen, G.↗

NASA NTRS1994

Drink composition and cycle-ergometer endurance in men: Carbohydrate, Na(+), osmolality

Cycle-ergometer endurance performance was determined in 5 untrained men (22-39 yr, 62.4-100.5 kg, 29-55 mL x min(exp -1) x kg(exp -1) peak oxygen uptake) after consuming Nothing (N) or two fluid formulations (10 mL x kg(exp -1), 555-998 mL). Performance 1 (P1), a multi-ionic-glucose rehydration drink, contains 55 mEq/L Na(exp +), 416 mg/dL citrate, 2,049 mg/dL glucose, and 365 mOsm/kgH2O. HyperAde (HA), a sodium chloride-citrate hyperhydration drink, contains 164 mEq/L Na(exp +), 854 mg/dL citrate, less than 0.5 mg/dL glucose, and 253 mOsm/kgH2O. Endurance at a load of 87-91 percent of peak VO2 was 30.50 +/- SE 3.44 min with HA; 24.55 +/- 1.09 min with P1 (p greater than 0.10 from HA); and 24.68 +/- 1.50 min with N (p less than 0.05 from HA). The attenuated endurance performance with P1 and N could not be attributed to differences in exercise metabolism, change or absolute level of rectal and mean skin temperature, or change in perceived exertion. The greater increase in resting plasma volume with HA, compared with P1 or N, probably contributed to the greater endurance with HA.

Greenleaf, J. E.↗

NASA NTRS1994

Hypervolemia in men from drinking hyperhydration fluids at rest and during exercise

To test the hypothesis that drink composition is more important than drink osmolality (Osm) for maintaining and increasing plasma volume (PV) at rest and during exercise, six men (22-39 yr, 76.84 +/- 16.19 kg, 2.99 +/- 0.45 L/min VO2 peak) each underwent six treatments while sitting for 90 min (VO2 = 0.39 L/min) and then performed upright ergometer exercise for 70 min (VO2 = 2.08 +/- 0.33 1/min, 70% +/- 7% VO2 peak). Drink formulations (10 ml/kg body weight, X = 768 ml) for the sitting period were: P1 (55 mEq Na(+), 365 mOsm/kg H2O), P2 (97.1 mEq Na(+), 791 mOsm/kg), P2G (113 mEqNa(+), 80 ml glycerol, 1,382 mOsm/kg, HyperAde (HA) (164 mEq Na(+), 253 mOsm/kg), and 01 and 02 (no drinking). The exercise drink (10 ml/kg, 768 ml) was P1 for all treatments except 02. Plasma volume at rest increased (p less than 0.05) by 4.7% with P1 and by 7.9% with HA. Percent change in PV during exercise was +1% to +3%0(NS) with HA; -6% to 0% (NS) with P1, P2, P2G, and 01; and -8% to -5% (p less than 0.05) with 02. HyperAde, with the lowest osmolality (253 mOsm/kg), maintained PV at rest and during exercise, whereas the other drinks with lower Na(+) and higher osmolality (365 to 1,382 mOsm/kg) did not. But Performance 1 also increased PV at rest. Thus, drink composition may be more important than drink osmolality for increasing plasma volume at rest and for maintaining it during exercise.

Greenleaf, J. E.↗

NASA NTRS1994

Hypervolemia During Drinking of ISO and Hypertonic Fluids by Men at Rest and Exercise

To test the hypothesis that drink composition is more important than osmolality (osm) for maintaining and increasing plasma vol. (PV, hypervolemia) at rest and exercise (21.8C Tdb, 50% rh), 6 men (22-39 vr) underwent six treatments while sitting for 90 min (0.39 l/min) followed by 70 min of sitting ergometer exercise (2.08 l/min, 70%vO2 peak). Resting, intermittent drinking (10 ml/kg, 768 ml) beverages were: P1 (20 mEq Na+, 365 mosmol/kg), P2 (40 mEq Na+. 791 mosm), P2G (40 mEq Na+, 80 ml glycerol, 1.392 mosm). AA (157 mEq Na+, 253 mosm), and 01 and 02 (nothing). The exercise drink (10 ml/kg, 768 ml) was P1 for all experiments, except 02 (nothing). Resting % delta PV (Hb-Hct) increased (P<0.05) by 3-6% only with P2 and AA, respectively, Exercise % delta PV was + 1 to + 3% (NS) with AA, -6% to 0% (KS) with P1, P2. P2G, and 01,and 8% to -5% (P<0.05) with 02- Thus, AA with 157 mEq Na+ and the lowest osmolality maintained PV at rest and exercise, while the other beverages with low Na+ and higher osmolality (365 to 1.382 mosm) did not.

Greenleaf, J. E.↗

NASA NTRS1993

Effect Of Leg Exercise On Vascular Volumes During Bed Rest

Report describes experiments on effects of no-exercise regimen and of two leg-exercise regimens on volumes of plasma, volumes of red blood cells, densities of bodies, and water balances of 19 men (32 to 42 years old) confined to minus 6 degrees-head-down bed rest for 30 days. Purpose of study to determine whether either or both exercise regimens maintain plasma volume and to relate levels of hypovolemia to body fluid balances. Results showed during bed rest, plasma volume maintained in isotomic group but not in other two groups, and no significant differences in body densities, body weights, or water balances among three groups. Concludes isotonic-exercise regimen better than isokinetic-exercise regimen for maintaining plasma volume during prolonged exposure to bed rest.

Greenleaf, J. E.↗

NASA NTRS1992

Effect of leg exercise training on vascular volumes during 30 days of 6 deg head-down bed rest

In order to investigate the effects of leg exercise training on vascular volumes during 30 d of 6-deg head-down bed rest, plasma and red cell volumes, body density, and water balance were measured in 19 men confined to bed rest (BR). One group had no exercise training (NOE), another near-maximal variable-intensity isotonic exercise (ITE) for 60 min/d, and the third near-maximal intermittent isokinetic exercise (IKE) for 60 min/d. Mean energy costs for the NOE, IKE, and ITE regimens were determined. Body densities within groups and mean urine volumes between groups were unchanged during BR. Changes in red cell volume followed changes in plasma volume. There was close coupling between resting plasma volume and plasma protein and osmotic content. It is argued that the ITE training protocol is better than the IKE protocol for maintaining plasma volume during prolonged exposure to BR.

Greenleaf, J. E.↗

NASA NTRS1992

Effect of leg exercise training on vascular volumes during 30 days of 6 degrees head-down bed rest

Plasma and red cell volumes, body density, and water balance were measured in 19 men (32-42 yr) confined to bed rest (BR). One group (n = 5) had no exercise training (NOE), another near-maximal variable-intensity isotonic exercise for 60 min/day (ITE; n = 7), and the third near-maximal intermittent isokinetic exercise for 60 min/day (IKE; n = 7). Caloric intake was 2,678-2,840 kcal/day; mean body weight (n = 19) decreased by 0.58 +/- 0.35 (SE) kg during BR due to a negative fluid balance (diuresis) on day 1. Mean energy costs for the NOE, and IKE, and ITE regimens were 83 (3.6 +/- 0.2 ml O2.min-1.kg-1), 214 (8.9 +/- 0.5 ml.min-1.kg-1), and 446 kcal/h (18.8 +/- 1.6 ml.min-1.kg-1), respectively. Body densities within groups and mean urine volumes (1,752-1,846 ml/day) between groups were unchanged during BR. Resting changes in plasma volume (ml/kg) after BR were -1.5 +/- 2.3% (NS) in ITE, -14.7 +/- 2.8% (P less than 0.05) in NOE, and -16.8 +/- 2.9% (P less than 0.05) in IKE, and mean water balances during BR were +295, -106, and +169 ml/24 h, respectively. Changes in red cell volume followed changes in plasma volume. The significant chronic decreases in plasma volume in the IKE and NOE groups and its maintenance in the ITE group could not be accounted for by water balance or by responses of the plasma osmotic, protein, vasopressin, or aldosterone concentrations or plasma renin activity. There was close coupling between resting plasma volume and plasma protein and osmotic content.(ABSTRACT TRUNCATED AT 250 WORDS).

NASA Discipline Regulatory Physiology↗

NASA NTRS1986

Effect of antigravity suit inflation on cardiovascular, PRA, and PVP responses in humans

The effects of lower body and abdominal pressure, produced by antigravity suit inflation, on blood pressure, pulse rate, fluid and electrolyte shift, plasma vasopressin and plasma renin activity in humans in upright postures were studied. Five men and two women stood upright for 3 hr with the suit being either inflated or uninflated. In the control tests, the suit was inflated only during the latter part of the trials. Monitoring was carried out with a sphygnomanometer, with sensors for pulse rates, and using a photometer and osmometer to measure blood serum characteristics. The tests confirmed earlier findings that the anti-g suit eliminates increases in plasma renin activity. Also, the headward redistribution of blood obtained in the tests commends the anti-g suit as an alternative to water immersion or bed rest for initial weightlessness studies.

Kravik, S. E.↗

NASA NTRS1984

Inhibition of plasma vasopressin after drinking in dehydrated humans

The effects of nonosmotic and nonvolumetric factors on vasopressin secretion in dehydrated humans has been investigated experimentally, before and after drinking. The subjects of the experiment were five adult men and three adult women weighing 69-77 kg. In order to determine the influence of nonosmotic and nonvolumetric factors on vasopressin secretion, measurements were obtained of the following blood hematological indices: serum Na(+) content; serum K(+) content; osmolality; and hemoglobin. Measurements of hematocrit, plasma arginine vasopressin (AVP), aldosterone, and renin activity were also obtained. It is found that dehydration increased mean serum Na(+) content, osmolality,and AVP. No significant changes were observed in renin activity, hemoglobin, hematocrit, or plasma volume, while plasma aldosterone increased from 11.1 ng/dl after dehydration to 15.6 ng/dl between 30 and 60 min after drinking. A rapid fall of AVP content following rehydration occurred in the absence of changes in the primary regulators of AVP osmolality and plasma volume, with no change in blood pressure. On the basis of the experimental results, it is suggested that oropharyngeal factors may be the mechanism, for the observed decrease in AVP following rehydration.

Geelen, G.↗

NASA NTRS1983

Hypervolemia and plasma vasopressin response during water immersion in men

Immersion studies were performed on seven mildly dehydrated male subjects to examine the effect of suppression of plasma vasopressin (PVP) on diuresis in water immersion. The water was kept at close to 34.5 C and the subjects remained in the water for 4 hr after sitting for 2 hr. Na and K levels in the serum and urine were analyzed, as were osmolality, red blood cell count, renin activity, total protein, albumin amounts, hematocrit, and hemoglobin. Plasma volume was monitored from samples drawn at specified intervals during immersion. The plasma volume increased significantly 30 min after immersion, but no PVP was observed. The dehydration induced elevated serum osmotic concentrations. It is concluded that the hydration condition before immersion and the volume of fluid intake during immersion affects the hemodilution during immersion.

Greenleaf, J. E.↗

NASA NTRS1982

A review of utility issues for the integration of wind electric generators

A review of issues and concerns of the electric utility industry for the integration of wind electric generation is offered. The issues have been categorized in three major areas: planning, operations, and dynamic interaction. Representative studies have been chosen for each area to illustrate problems and to alleviate some concerns. The emphasis of this paper is on individual large wind turbines (WTs) and WT arrays for deployment at the bulk level in a utility system.

Reddoch, T. W.↗