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Boni, Robert

Publications and source records attributed to Boni, Robert.

High-Density Polyethylene Custom Focusing Lenses for High-Resolution Transient Terahertz Biomedical Imaging Sensors

Transient terahertz time-domain spectroscopy (THz-TDS) imaging has emerged as a novel non-ionizing and noninvasive biomedical imaging modality, designed for the detection and characterization of a variety of tissue malignancies due to their high signal-to-noise ratio and submillimeter resolution. We report our design of a pair of aspheric focusing lenses using a commercially available lens-design software that resulted in about 200 × 200-μm2 focal spot size corresponding to the 1-THz frequency. The lenses are made of high-density polyethylene (HDPE) obtained using a lathe fabrication and are integrated into a THz-TDS system that includes low-temperature GaAs photoconductive antennae as both a THz emitter and detector. The system is used to generate high-resolution, two-dimensional (2D) images of formalin-fixed, paraffin-embedded murine pancreas tissue blocks. The performance of these focusing lenses is compared to the older system based on a pair of short-focal-length, hemispherical polytetrafluoroethylene (TeflonTM) lenses and is characterized using THz-domain measurements, resulting in 2D maps of the tissue refractive index and absorption coefficient as imaging markers. For a quantitative evaluation of the lens effect on the image resolution, we formulated a lateral resolution parameter, R2080, defined as the distance required for a 20–80% transition of the imaging marker from the bare paraffin region to the tissue region in the same image frame. The R2080 parameter clearly demonstrates the advantage of the HDPE lenses over TeflonTM lenses. The lens-design approach presented here can be successfully implemented in other THz-TDS setups with known THz emitter and detector specifications.

47 OTHER INSTRUMENTATION↗

Advanced Photon Acceleration Schemes for Tunable XUV/Soft X-Ray Sources

We report on the advances made under the purview of DOE award number DE-SC0019135 that was active during the period: 09/01/2018–08/31/2021. The grant investigated the application of a “flying focus” to the problem of photon acceleration—in which a dynamic refractive index gradient is used to continuously upshift a probe beam’s frequency. Codes were written to describe the creation of ionization waves of arbitrary velocity (IWAVs) for use as a photon-accelerating medium, as well as the behavior of a witness pulse residing in said medium. Experiments first verified the spatiotemporal control over laser intensity provided by a chromatic flying focus, then used that ability to produce small-diameter IWAVs in the far-field with the expected dynamics, and finally demonstrated even further flexibility by producing large-diameter IWAVs in the laser quasi-far-field that maintained the beneficial dynamics. Multiple innovative diagnostics—spectrally resolved Schlieren and spectrally resolved interferometry—were pioneered in order to diagnose the IWAVs. For IWAV production in the laboratory, however, beam quality was identified as a key limitation in the quasi-far-field. Since the original chromatic flying focus was found to result in relatively long (ps duration) intensity peaks, which could limit some applications including photon acceleration, additional techniques were invented to provide similar spatiotemporal control while also retaining ultrashort intensity peaks. While simulations have identified several interesting regimes for photon acceleration—first predicting the upshift of a counterpropagating witness pulse from the optical to the extreme ultraviolet in less than 1 cm, and later obtaining similar shifts in less than 100 μm in a simpler self-seeded configuration—experimental demonstration is left for future work.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗