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Castle, B. L.

Publications and source records attributed to Castle, B. L..

Computer program for calculation of oxygen uptake

A description and operational precedures are presented for a computer program, written in Super Basic, that calculates oxygen uptake, carbon dioxide production, and related ventilation parameters. Program features include: (1) the option of entering slope and intercept values of calibration curves for the O2 and CO2 and analyzers; (2) calculation of expired water vapor pressure; and (3) the option of entering inspured O2 and CO2 concentrations. The program is easily adaptable for programmable laboratory calculators.

Castle, B. L.

Body water compartments during bed rest: Evaluation of analytical methods

Nine healthy young men were studied to determine the reproducibility and interchangeability of the use of radio-iodinated human serum albumin and Evans Blue dye for estimating plasma volume, sodium bromide for extracellular fluid volume, and deuterium oxide for total body water volume. All subjects were tested in a semibasal condition and allowed to rest for at least 30 min. after arriving at the laboratory. The results indicate that there was uniform distribution of I131 and Evans Blue dye 10 min. after injection and of NaBr and D2O 3 hours after oral ingestion; the buildup of residual tracer did not interfere appreciably with the measurement of either or Evans Blue spaces when they are administered at equal intervals, and the buildup of background tracer after ingestion of NaBr and D2O once per week for three consecutive weeks did not affect the accuracy of the measurement. It was found that I131 and Evans Blue may be used interchangeably for estimating plasma volume; for estimating bromide and D2O spaces, one 3-hour equilibrium blood sample gives results similar to the extrapolation of multiple samples.

Young, H. L.

Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs.

This investigation set out to answer two questions: (1) are the distal alveoli in the terminal lung units less well perfused than the proximal alveoli, i.e., is there stratification of blood flow; and (2) if so, does this enhance gas exchange in the presence of stratified inequality of ventilation. Excised dog lungs were ventilated with saline and perfused with blood. Following single inspirations of xenon 133 in saline and various periods of breath holding, the expired xenon concentration against volume was measured and it confirmed marked stratified inequality of ventilation under these conditions. By measuring the rate of depletion of xenon from alveoli during a period of blood flow, we showed that the alveoli which emptied at the end of expiration had 16% less blood flow than those exhaling earlier. However, by measuring the xenon concentration in pulmonary venous blood, we found that about 10% less tracer was transferred from the alveoli into the blood when the inspired xenon was stratified within the respiratory zone. Thus while stratification of blood flow was confirmed, it was shown to impair rather than enhance the efficiency of gas transfer.

West, J. B.

External auditory canal temperature as an estimate of core temperature.

Measurement of rectal (T sub re), auditory canal (T sub ac), positioned 8 to 10 mm from the tympanic membrane, and mean skin temperature (mean T sub sk) in five men during various exercise regimens at an ambient temperature (T sub a) of 25 C (phase one) and in two men during rest and exercise at 5, 15, 25, and 35 C T sub a (phase two). The purpose was to determine if T sub ac can be used as an accurate estimate of core temperature. Previous observations that T sub ac was highly correlated with T sub re but T sub ac was consistently lower than T sub re are confirmed; the mean difference varied from 0.4 C at rest to 1.1 C at the end of exercise. It is concluded that auditory canal temperature cannot be utilized as an estimate of core temperature, but T sub ac may be used to estimate mean body temperature where very accurate measurements are not required.

Greenleaf, J. E.

Maximal Oxygen Uptake, Sweating and Tolerance to Exercise in the Heat

The physiological mechanisms that facilitate acute acclimation to heat have not been fully elucidated, but the result is the establishment of a more efficient cardiovascular system to increase heat dissipation via increased sweating that allows the acclimated man to function with a cooler internal environment and to extend his performance. Men in good physical condition with high maximal oxygen uptakes generally acclimate to heat more rapidly and retain it longer than men in poorer condition. Also, upon first exposure trained men tolerate exercise in the heat better than untrained men. Both resting in heat and physical training in a cool environment confer only partial acclimation when first exposed to work in the heat. These observations suggest separate additive stimuli of metabolic heat from exercise and environmental heat to increase sweating during the acclimation process. However, the necessity of utilizing physical exercise during acclimation has been questioned. Bradbury et al. (1964) have concluded exercise has no effect on the course of heat acclimation since increased sweating can be induced by merely heating resting subjects. Preliminary evidence suggests there is a direct relationship between the maximal oxygen uptake and the capacity to maintain thermal regulation, particularly through the control of sweating. Since increased sweating is an important mechanism for the development of heat acclimation, and fit men have high sweat rates, it follows that upon initial exposure to exercise in the heat, men with high maximal oxygen uptakes should exhibit less strain than men with lower maximal oxygen uptakes. The purpose of this study was: (1) to determine if men with higher maximal oxygen uptakes exhibit greater tolerance than men with lower oxygen uptakes during early exposure to exercise in the heat, and (2) to investigate further the mechanism of the relationship between sweating and maximal work capacity.

Greenleaf, J. E.