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NASA NTRS2000

Loads Combination Research at Marshall Space Flight Center

This is the result of a study conducted by the Structural Dynamics Division of the Marshall Space Flight Center concerning the combination of low- and high-frequency dynamic loads for spacecraft design. Low-frequency transient loads are combined with high frequency acoustically induced loads to arrive at a limit load, for design purposes. Different methods are used for combining the loads which can lead to considerable variation in limit loads, depending on which NASA Center did the calculation. This study investigates several different combination methods and compares the combination methods with Spacelab 1 flight data. In addition, the relative timing of low- and high-frequency loads is examined.

Ferebee, R.↗

NASA NTRS2000

Loads Combination Research at Marshall Space Flight Center

This is the result of a study conducted by the Structural Dynamics Division of the Marshall Space Flight Center concerning the combination of low- and high-frequency dynamic loads for spacecraft design. Low-frequency transient loads are combined with high frequency acoustically induced loads to arrive at a limit load, for design purposes. Different methods are used for combining the loads which can lead to considerable variation in limit loads, depending on which NASA Center did the calculation. This study investigates several different combination methods and compares the combination methods with Spacelab 1 flight data. In addition, the relative timing of low- and high-frequency loads is examined.

Ferebee, R.↗

NASA NTRS1996

Use of bed rest and head-down tilt to simulate spaceflight-induce immune system changes

Bed rest, both with and without head-down tilt, has been extensively used as an earth-bound analog to study physiologic effects mimicking those occurring in weightlessness during spaceflight. We have been able to show in six subjects that 4 weeks of head-down tilt bed rest induces a significant decrease in interleukin-2 secretion by PHA-stimulated T lymphocytes. Another study, lasting 113 days, with two subjects showed a decreased interleukin-2 receptor expression in PHA-stimulated peripheral blood mononuclear cells but a decreased interleukin-2 production in one subject only. Under the same conditions, interleukin-1 production was largely increased in both subjects. Several other immune parameters were also analyzed. Increased interleukin-1 production could contribute to bone mineral loss encountered during bed rest and decreased interleukin-2 secretion could play a role in the appearance of infectious diseases often observed during bed red.

NASA Discipline Neuroscience↗