DNA Breaks Clustering Into Radiation-Induced Foci Predicts Cell Death for A Broad Range of Radiation Quality
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Engineering topics
Publications and source records attributed to Floriane Poignant.
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Microdosimetry is used to estimate quality factors for risk assessment in radiation protection and to quantify relative biological effectiveness (RBE) for treatment planning of hadron radiation therapy. Radiation physics has shown that energetic ions deposit energy in a complex manner: the track structure. The Local Effect Model (LEM) is often used as an approximation to describe this complex track structure. We have previously calculated an analytical expression for the dose to a spherical target fully located in the penumbra of an ion track using the LEM. In this work, the calculation has been extended to all impact parameters. Furthermore, using these analytical expressions, it was possible to obtain the theoretical energy deposition spectra to a sphere irradiated uniformly.
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