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Gonzalez, David

Publications and source records attributed to Gonzalez, David.

6 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus

Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a life-threatening disease with up to a 40% mortality rate. With no approved medical countermeasures, CCHFV is considered a public health priority agent. The non-neutralizing mouse monoclonal antibody (mAb) 13G8 targets CCHFV glycoprotein GP38 and protects mice from lethal CCHFV challenge when administered prophylactically or therapeutically. Here, we reveal the structures of GP38 bound with a human chimeric 13G8 mAb and a newly isolated CC5-17 mAb from a human survivor. These mAbs bind overlapping epitopes with a shifted angle. The broad-spectrum potential of c13G8 and CC5-17 and the practicality of using them against Aigai virus, a closely related nairovirus were examined. Binding studies demonstrate that the presence of non-conserved amino acids in Aigai virus corresponding region prevent CCHFV mAbs from binding Aigai virus GP38. This information, coupled with in vivo efficacy, paves the way for future mAb therapeutics effective against a wide swath of CCHFV strains.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2022

High-temperature analysis of optical coupling using AlGaAs/GaAs LEDs for high-density integrated power modules

A low-temperature co-fired ceramic (LTCC)-based optocoupler design is demonstrated as a possible solution for optical isolation in high-density integrated power modules. The design and fabrication of LTCC based package are discussed. Commercially available aluminum gallium arsenide/gallium arsenide (AlGaAs/GaAs) double heterostructure is used both as emitter and photodetector in the proposed optocoupler. A detailed study on the electroluminescence and spectral response of the AlGaAs/GaAs structure is conducted at elevated temperatures. The material figure of merit parameter, D*, is calculated in the temperature range 77–800 K. The fabricated optocoupler is tested at elevated temperatures, and the results are presented.

42 ENGINEERING↗
NASA NTRS2019

Deployable CubeSat Antennas for Deep Space and Earth Science Missions

New antenna technologies have unlocked a new class of missions using CubeSats for Earth Science or Deep Space operations. This class of small satellites have historically been mostly used as teaching tools allowing students to design and test small satellites and develop space experiments. With the rise of new game-changing antenna technologies, overcoming their small size and need for high gain, they can now be used beyond Low Earth Orbit (LEO). Over the past 5 years, technologists at the Jet Propulsion Laboratory have designed, tested and successfully flown these innovative Smallsat antennas, enabling new telecommunication and science achievements.

Cwik, Tom↗
NASA NTRS2016

COWVR Instrument Antenna, Performance Verification and Test Results

This paper describes the test campaign and the results used to verify the performance of the Compact Ocean Wind Vector Radiometer (COWVR) instrument antenna. Developed as a proof-of-concept technology demonstration mission, it’s planned for launch in 2016. Using small mass and low power, when compared to other instruments with similar capabilities, COWVR promises to obtain the same wind vector retrieval accuracy. COWVR was designed and developed at Jet Propulsion Laboratory (JPL) in collaboration with the US Air Force Space Missile Command.

off-set reflector↗