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Guo, Dongmei

Publications and source records attributed to Guo, Dongmei.

Note: Design of a laser feedback interferometer with double diffraction system

A novel laser feedback interferometer with double diffraction system is proposed in this paper. A beam emitted from the laser is incident onto a transmission grating. The mth order beam is vertically reflected by a mirror and diffracted again by the grating. The double-diffracted beam returns into the laser cavity and mixes with the light inside the active cavity, thus generating a modulation of both the amplitude and the frequency of the lasing field. Theoretical analysis and experimental observations show that the output signal of the proposed system depends on the grating pitch and the direction of the phase movement can be obtained from inclination of the interference signal. It provides a potential displacement sensor with high stability and quite a compact configuration.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Farnesoid X receptor up-regulates expression of Lipid transfer inhibitor protein in liver cells and mice

Highlights: •FXR up-regulates apoF. •It binds to ER1 element. •It activates apoF gene promoter. -- Abstract: Apolipoprotein F is a component protein mainly secreted by liver and resides on several lipoprotein classes. It can inhibit lipids transfer between different lipoproteins. FXR is a member of the nuclear receptor superfamily which is also highly expressed in the liver. It modulates bile acids synthesis and lipids metabolism by transcriptional regulation. We aimed to determine whether apoF can be regulated by FXR. The FXR agonist Chenodeoxycholic acid (CDCA) and GW4064 both can activate the expression of apoF in liver cell lines and in C57/BL6 mouse liver. This is dependent on the binding of FXR to the FXR element ER1 (−2904 to −2892 bp) in the apoF gene promoter. Taken together, we have identified apoF as likely another target gene of FXR.

60 APPLIED LIFE SCIENCES↗