BioSentinel: DNA Damage-and-Repair Experiment Beyond Low Earth Orbit
No abstract available
BioSentinel↗
Engineering topics
Hanel, Robert P.
Publications and source records attributed to Hanel, Robert P..
BioSentinel: Monitoring DNA Damage Repair Beyond Low Earth Orbit on a 6U Nanosatellite
We are designing and developing a 6U nanosatellite as a secondary payload to fly aboard NASAs Space Launch System (SLS) Exploration Mission (EM) 1, scheduled for launch in late 2017. For the first time in over forty years, direct experimental data from biological studies beyond low Earth orbit (LEO) will be obtained during BioSentinels 12- to 18-month mission. BioSentinel will measure the damage and repair of DNA in a biological organism and allow us to compare that to information from onboard physical radiation sensors. This data will be available for validation of existing models and for extrapolation to humans.The BioSentinel experiment will use the organism Saccharomyces cerevisiae (yeast) to report DNA double-strand-break (DSB) events that result from space radiation. DSB repair exhibits striking conservation of repair proteins from yeast to humans. The flight strain will include engineered genetic defects that prevent growth and division until a radiation-induced DSB activates the yeasts DNA repair mechanisms. The triggered culture growth and metabolic activity directly indicate a DSB and its repair. The yeast will be carried in the dry state in independent microwells with support electronics. The measurement subsystem will sequentially activate and monitor wells, optically tracking cell growth and metabolism. BioSentinel will also include TimePix radiation sensors implemented by JSCs RadWorks group. Dose and Linear Energy Transfer (LET) data will be compared directly to the rate of DSB-and-repair events measured by the S. cerevisiae biosentinels. BioSentinel will mature nanosatellite technologies to include: deep space communications and navigation, autonomous attitude control and momentum management, and micropropulsion systems to provide an adaptable nanosatellite platform for deep space uses.
cosmic rays↗
A Mars environmental SURvey (MESUR) - Feasibility of a low cost global approach
Explore the source record for details and available documents.
Hubbard, G. S.↗
Starting small on the road to Mars
Three small inexpensive mission concepts for Mars landing and exploration are described emphasizing expected scientific returns that can lead to human exploration. The Mars Explorer mission prepares for human missions by means of landing-site reconnaissance and characterization, while the Surface Lander Investigation of Mars mission uses a single probe and robotics to image the surface and analyze samples. The Mars Environmental Survey experiment is reported in which robotics are employed to study the soil, atmosphere, weather and seismic activity on the red planet.
Hanel, Robert P.↗
Mars Environmental Survey (MESUR): Science objectives and mission description
In-situ observations and measurements of Mars are objectives of a feasibility study beginning at the Ames Research Center for a mission called the Mars Environmental SURvey (MESUR). The purpose of the MESUR mission is to emplace a pole-to-pole global distribution of landers on the Martian surface to make both short- and long-term observations of the atmosphere and surface. The basic concept is to deploy probes which would directly enter the Mars atmosphere, provide measurements of the upper atmospheric structure, image the local terrain before landing, and survive landing to perform meteorology, seismology, surface imaging, and soil chemistry measurements. MESUR is intended to be a relatively low-cost mission to advance both Mars science and human presence objectives. Mission philosophy is to: (1) 'grow' a network over a period of years using a series of launch opportunities, thereby minimizing the peak annual costs; (2) develop a level-of-effort which is flexible and responsive to a broad set of objectives; (3) focus on science while providing a solid basis for human exploration; and (4) minimize project cost and complexity wherever possible. In order to meet the diverse scientific objectives, each MESUR lander will carry the following strawman instrument payload consisting of: (1) Atmospheric structure experiment, (2) Descent and surface imagers, (3) Meteorology package, (4) Elemental composition instrument, (5) 3-axis seismometer, and (6) Thermal analyzer/evolved gas analyzer. The feasibility study is primarily to show a practical way to design an early capability for characterizing Mars' surface and atmospheric environment on a global scale. The goals are to answer some of the most urgent questions to advance significantly our scientific knowledge about Mars, and for planning eventual exploration of the planet by robots and humans.
Hubbard, G. Scott↗
A Mars environmental survey (MESUR) - Feasibility of a low cost global approach
In situ measurements of Mars' surface and atmosphere are the objectives of a novel network mission concept called the Mars Environmental SURvey (MESUR). As envisioned, the MESUR mission will emplace a pole-to-pole global distribution of 16 landers on the Martian surface over three launch opportunites using medium-lift (Delta-class) launch vehicles. The basic concept is to deploy small free-flying probes which would directly enter the Martian atmosphere, measure the upper atmospheric structure, image the local terrain before landing, and survive landing to perform meteorology, seismology, surface imaging, and soil chemistry measurements. Data will be returned via dedicated relay orbiter or direct-to-earth transmission. The mission philosophy is to: (1) 'grow' a network over a period of years using a series of launch opportunities; (2) develop a level-of-effort which is flexible and responsive to a broad set of objectives; (3) focus on Mars science while providing a solid basis for future human presence; and (4) minimize overall project cost and complexity wherever possible.
Hubbard, G. S.↗
Mission optimization of the Space Infrared Telescope Facility
The Space Infrared Telescope Facility (SIRTF) mission based on a cryogenically cooled telescope is described. The SIRTF makes it possible to perform background limited measurements with three focal plane instruments in the wavelength range 2-700 microns over the entire celestial sphere for at least five years. A telescope performance limited by the natural astrophysical background between 2 to 300 microns is achieved by using a superfluid helium cryogenic system for maintaining the forebaffle temperature below 8 K. The attitude control system based on Extreme Ultra-Violet Explorer reaction wheels meets the large and small angle slew requirements and provides 0.15 arc sec pointing stability. The present HEO baseline configuration has a mass of 4370 kg. The future Titan IV/Centaur launch capability to 100,000 km for a SIRTF-sized payload is at least 5770 kg.
Brooks, Walter F.↗