Search NASA⌕ Search

Engineering topics

Harrison, D. C.

Publications and source records attributed to Harrison, D. C..

At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1986

Effects of simulated weightlessness on regional blood flow specifically during cardiovascular stress

Significant changes in the cardiovasular system of humans and animals have been observed following exposure to prolonged periods of weightlessness during space flight. Although adaption to weightlessness is relatively uncomplicated, marked changes in cardiovascular deconditioning become evident upon return to normal gravity, including orthostatic hypotension and tachycardia. Some evidence that myocardial degeneration occurs has been demonstrated in animals who have been immobilized for two months. Also, evidence of possible loss of myocardial mass following manned space flight has been obtained by means of echocardiographic studies. These findings have serious implications in light of the increasing frequency and duration of Space Shuttle missions and the prospect of extended space station missions in the future. A number of both military and civilian investigators, including middle-aged scientists, will probably encounter prolonged periods of weightlessness. It has been imperative, therefore, to determine the effects of prolonged weightlessness on cardiovascular deconditioning and whether such effects are cumulative or reversible. The research project conducted under NASA Cooperative Agreement NCC 2-126 was undertaken to determine the effects of prolonged simulated weightlessness on regional blood flow. Research results are reported in the three appended publications.

Harrison, D. C.↗
NASA NTRS1982

Pharmacologic counter measures minimizing post-space flight orthostatic intolerance

The effect of bed rest on drug disposition and physiological function was investigated as part of a project to determine the cardiovascular effects of space flight. One group of subjects was given doses of lidocane, penicillin-G, and ICG during a control period and following seven days of bed rest. Cardiac function was evaluated by echo-cardiography. Renal function was evaluated in a second group before and after several days of bed rest. Inulin, para-aminohippurate, and dextran clearances were studied. In the first group, the post-bed rest parameters were not statistically different from the pre-bed rest valves. In the second study, renal function did not change significantly after seven days of bed rest. Plans for future research are reviewed.

Harrison, D. C.↗
NASA NTRS1980

Crossed-grid charge locator

Circuit locates center of cloud of charge on wire grid to within 6.5 micrometers. Wires in vicinity of charge cloud develop voltages that are processed by priority encoders to develop coarse and fine position codes. Device is used with microchannel plate amplifier in X-ray photon detectors, electron microscopes, and closed-circuit television.

Harrison, D. C.↗
NASA NTRS1980

Biomedical technology transfer. Applications of NASA science and technology

Ongoing projects described address: (1) intracranial pressure monitoring; (2) versatile portable speech prosthesis; (3) cardiovascular magnetic measurements; (4) improved EMG biotelemetry for pediatrics; (5) ultrasonic kidney stone disintegration; (6) pediatric roentgen densitometry; (7) X-ray spatial frequency multiplexing; (8) mechanical impedance determination of bone strength; (9) visual-to-tactile mobility aid for the blind; (10) Purkinje image eyetracker and stabilized photocoalqulator; (11) neurological applications of NASA-SRI eyetracker; (12) ICU synthesized speech alarm; (13) NANOPHOR: microelectrophoresis instrument; (14) WRISTCOM: tactile communication system for the deaf-blind; (15) medical applications of NASA liquid-circulating garments; and (16) hip prosthesis with biotelemetry. Potential transfer projects include a person-portable versatile speech prosthesis, a critical care transport sytem, a clinical information system for cardiology, a programmable biofeedback orthosis for scoliosis a pediatric long-bone reconstruction, and spinal immobilization apparatus.

Harrison, D. C.↗
NASA NTRS1980

CCD camera systems and support electronics for a White Light Coronagraph and X-ray XUV solar telescope

Two instruments, a White Light Coronagraph and an X-ray XUV telescope built into the same housing, share several electronic functions. Each instrument uses a CCD as an imaging detector, but due to different spectral requirements, each uses a different type. Hardware reduction, required by the stringent weight and volume allocations of the interplanetary mission, is made possible by the use of a microprocessor. Most instrument functions are software controlled with the end use circuits treated as peripherals to the microprocessor. The instruments are being developed for the International Solar Polar Mission.

Harrison, D. C.↗
NASA NTRS1980

A quadratic analog-to-digital converter

An analog-to-digital converter with a square root transfer function has been developed for use with a pair of CCD imaging detectors in the White Light Coronagraph/X-ray XUV Telescope experiment to be flown as part of the Internal Solar Polar Mission. It is shown that in background-noise-limited instrumentation systems a quadratic analog-to-digital converter will allow a maximum dynamic range with a fixed number of data bits. Low power dissipation, moderately fast conversion time, and reliability are achieved in the proposed design using standard components and avoiding nonlinear elements.

Harrison, D. C.↗
NASA NTRS1978

The High Resolution Imaging Instrument for HEAO-B

The High Resolution Imaging Instrument for the HEAO-B X-ray Telescope satellite is designed to reproduce images of celestial X-ray sources in the range of 0.2 to 4.0 keV. It provides both imaging and temporal data. The basic detector is a two-stage microchannel plate with a crossed-grid charge detector. Preamplifiers, detector bias supplies, and some processing circuits are colocated with the detector. The remaining electronic circuits are located in a remote central electronic assembly. The processing system is designed for single-photon processing. The imaging data rate is limited to 100 data points per second. Non-imaging total-field count rate is acquired with a maximum dead time of 14 microseconds per event.

Kubierschky, K.↗
NASA NTRS1975

Diagnostic accuracy of an ultrasonic multiple transducer cardiac imaging system

An ultrasonic multiple-transducer imaging system for intracardiac structure visualization is developed in order to simplify visualization of the human heart in vivo without radiation hazard or invasion of the body. Results of the evaluation of the diagnostic accuracy of the devised system in a clinical setting for adult patients are presented and discussed. Criteria are presented for recognition of mitral valva prolapse, mitral stenosis, pericardial effusion, atrial septal defect, and left ventricular dyssynergy. The probable cause for false-positive and false-negative diagnoses is discussed. However, hypertrophic myopathy and congestive myopathy were unable to be detected. Since only qualitative criteria were used, it was not possible to differentiate patients with left ventricular volume overload from patients without cardiac pathology.

Popp, R. L.↗
NASA NTRS1975

Effect of varying differentiator frequency response on recorded peak dP/dt

Dogs were used to study the effects of varying the differentiator cutoff frequency on the recorded peak first derivative of left ventricular pressure with respect to time (dP/dt), using high-precision solid-state pressure transducers and recording equipment. In canine hearts with a basic periodicity of 1 to 3 Hz, the differentiator frequency response required to record an accurate peak dP/dt is found to be influenced by the value of peak dP/dt. At peak dP/dt ranging from 1500 to 9000 mm Hg/sec (200 and 1200 kPa/sec), a differentiator cutoff frequency of at least 90 Hz was required to record accurately peak dP/dt.

Barry, W. H.↗
NASA NTRS1975

Computer processing of echocardiographic images

Systems for direct computer acquisition of the echo signal and subsequent computerized echocardiogram image processing were constructed. Such systems were used to generate images unobtainable by other techniques and to automatically perform quantitative measurements of cardiac structures (5,6,7). The techniques used in analyzing echocardiograms are discussed, and the complexity of the problems involved is illustrated. A description of how these problems may be solved is included.

Sanders, W. J.↗
NASA NTRS1975

Cardiovascular imaging and image processing: Theory and practice - 1975; Proceedings of the Conference, Stanford University, Stanford, Calif., July 10-12, 1975

The present collection of papers outlines advances in ultrasonography, scintigraphy, and commercialization of medical technology as applied to cardiovascular diagnosis in research and clinical practice. Particular attention is given to instrumentation, image processing and display. As necessary concomitants to mathematical analysis, recently improved magnetic recording methods using tape or disks and high-speed computers of large capacity are coming into use. Major topics include Doppler ultrasonic techniques, high-speed cineradiography, three-dimensional imaging of the myocardium with isotopes, sector-scanning echocardiography, and commercialization of the echocardioscope. Individual items are announced in this issue.

Harrison, D. C.↗
NASA NTRS1975

The user's view of commercially available medical technology

The potential user of new medical equipment for imaging the cardiovascular system is often faced with the problem of deciding whether or not to accept a new piece of equipment or a new technological concept into the practice of cardiology. Considerations for acquiring new medical technology are discussed in some detail. Acquisition of new technology should depend on whether the equipment provides more and relevant clinical data, is for research or for limited use, is properly engineered for patient use, presents information in easily storable and retrievable form, is tested and validated clinically, is fabricated by a reliable manufacturer, is cost effective, and may be readily replaced by a new technology.

Harrison, D. C.↗
NASA NTRS1974

An improved method for echographic detection of left atrial enlargement

Echographic dimensions of the aortic root and left atrium were compared in 170 patients in order to assess dilation of the left atrium with reference to the relatively nondistensible fibrous aortic root. In 50 patients without cause for left atrial or aortic enlargement, the ratio of left atrial/aortic root dimensions was 0.87 to 1.11. In 80 patients with known cause for left atrial enlargement, the left atrial/aortic root ratio was greater than or equal to 1.17. In 40 patients with isolated valve disease, dilation of both the aortic root and the left atrium resulted in a left atrial/aortic root dimension ratio less than 1.17 in some patients. Despite this consideration, the comparison of left atrial and aortic root dimension appears to be as specific as, and more sensitive than, previously proposed methods for the evaluation of left atrial enlargement.

Brown, O. R.↗
NASA NTRS1974

Alterations in left ventricular volumes induced by Valsalva manoeuvre

Five patients were studied with left ventriculography during different phases of the Valsalva manoeuvre. Small doses of contrast medium allowed adequate repetitive visualization of the left ventricle for volume calculation. During strain phase, the volume of the left ventricle decreased by nearly 50 per cent in each case, and stroke volume and cardiac output also dropped strikingly. Release of straining was attended by a sharp rebound of left ventricular volume to control levels, with a transient surge of increased cardiac output 42 per cent above that of the resting state.

Brooker, J. Z.↗
NASA NTRS1972

Evaluation of the pulse-contour method of determining stroke volume in man.

The pulse-contour method for determining stroke volume has been employed as a continuous rapid method of monitoring the cardiovascular status of patients. Twenty-one patients with ischemic heart disease and 21 patients with mitral valve disease were subjected to a variety of hemodynamic interventions. The pulse-contour estimations, using three different formulas derived by Warner, Kouchoukos, and Herd, were compared with indicator-dilution outputs. A comparison of the results of the two methods for determining stroke volume yielded correlation coefficients ranging from 0.59 to 0.84. The better performing Warner formula yielded a coefficient of variation of about 20%. The type of hemodynamic interventions employed did not significantly affect the results using the pulse-contour method. Although the correlation of the pulse-contour and indicator-dilution stroke volumes is high, the coefficient of variation is such that small changes in stroke volume cannot be accurately assessed by the pulse-contour method. However, the simplicity and rapidity of this method compared to determination of cardiac output by Fick or indicator-dilution methods makes it a potentially useful adjunct for monitoring critically ill patients.

Alderman, E. L.↗
NASA NTRS1972

Action of acetylstrophanthidin on experimental myocardial infarction.

An experimental animal model with acute myocardial infarction of a size insufficient to produce profound heart failure or shock was used to study the effects of acute infarction on digitalis tolerance and the hemodynamic changes produced by moderate and large doses of acetylstrophanthidin. With acute myocardial infarction, digitalis toxic arrhythmias could be precipitated with significantly lower doses of digitalis than in animals without myocardial infarction. There was no precise correlation between the size of infarction and the toxic dose of glycoside. Coronary artery ligation produced a stable but relatively depressed circulatory state, as evidenced by lowered cardiac output and stroke volume and elevated systemic vascular resistance and left atrial mean pressure. When digitalis was infused, the following significant changes were observed at nontoxic doses: (1) elevation of aortic and left ventricular pressures; (2) further decline in cardiac output; and (3) decreased left atrial mean pressure.

Nola, G. T.↗
NASA NTRS1971

Circulatory responses to hypoxia in experimental myocardial infarction.

Three levels of decreased arterial oxygen saturation elicited a graded circulatory response in dogs, manifested by stepwise increases in cardiac output, left ventricular dp/dt, and stroke volume, and decreases in systemic vascular resistance. Responses to similar hypoxia challenges after experimental myocardial infarction were qualitatively similar but quantitatively less. Although the circulatory compensation for hypoxia was less effective after myocardial infarction, no further deterioration of the haemodynamics was noted.

Schroll, M.↗