Entropic destruction of heavy quarkonium in non-Abelian plasma from holography
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Hashimoto, Koji↗
Engineering topics
Hashimoto, Koji
Publications and source records attributed to Hashimoto, Koji.
Nuclear Matrix Model: A path to nuclear physics from superstrings
We derive nuclear forces and nuclear density saturation from large N{sub c} QCD, by applying AdS/CFT correspondence of string theory, called holographic QCD. This is made possible by a new description of a multi-baryon system in the holographic QCD. The description employs a matrix quantum mechanics which can be derived via the correspondence. This talk is based on collaboration work with N. Iizuka and P. Yi [1], with N. Iizuka [2, 3] and with T. Morita [4].
73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation
Highlights: {yields} VEGF-A enhanced lymphatic endothelial cell migration and increased tube formation. {yields} VEGF-A treated lymphatic endothelial cell showed activation of STAT3. {yields} Dominant-negative STAT3 inhibited VEGF-A-induced lymphatic endothelial cell migration and tube formation. -- Abstract: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific growth factor that regulates endothelial functions, and signal transducers and activators of transcription (STATs) are known to be important during VEGF receptor signaling. The aim of this study was to determine whether STAT3 regulates VEGF-induced lymphatic endothelial cell (LEC) migration and tube formation. VEGF-A (33 ng/ml) enhanced LEC migration by 2-fold and increased tube length by 25% compared with the control, as analyzed using a Boyden chamber and Matrigel assay, respectively. Western blot analysis and immunostaining revealed that VEGF-A induced the nuclear translocation of phosphorylated STAT3 in LECs, and this translocation was blocked by the transfection of LECs with an adenovirus vector expressing a dominant-negative mutant of STAT3 (Ax-STAT3F). Transfection with Ax-STAT3F also almost completely inhibited VEGF-A-induced LEC migration and tube formation. These results indicate that STAT3 is essential for VEGF-A-induced LEC migration and tube formation and that STAT3 regulates LEC functions.
60 APPLIED LIFE SCIENCES↗