Engineering topics
Publications and source records attributed to Huang, Yan.
Substituting electron-donating and electron-accepting substituents on antiaromatic pentalene cores can significantly tune the optical absorption, energy levels, antiaromaticity, and transistor switch-on behavior.
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Chemotherapy and concurrent thoracic radiation therapy (CCTRT) followed by prophylactic cranial irradiation (PCI) is the standard of care for limited-stage small cell lung cancer (LS-SCLC). We aimed to compare the efficacy and toxicity of moderately hypofractionated once-daily CCTRT with that of a standard twice-daily regimen.
Self-interacting dark matter (SIDM) is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies. Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions. If the mediator couples to the standard model particles, it could produce characteristic signals in dark matter direct detection experiments. We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment, basing on a total exposure of 132 tonne-days. No significant excess over background is found, and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength. We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe, and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator.
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Hypomyelination, a neurological disorder characterized by a decrease in the production of myelin sheets by glial cells, often has no known etiology. Elucidating the genetic causes of hypomyelination provides a better understanding of myelination, as well as means to diagnose, council, and treat patients. Here, we present evidence that YIPPEE LIKE 3 (YPEL3), a gene whose developmental role was previously unknown, is required for central and peripheral glial cell development. We identified a child with a constellation of clinical features including cerebral hypomyelination, abnormal peripheral nerve conduction, hypotonia, areflexia, and hypertrophic peripheral nerves. Exome and genome sequencing revealed a de novo mutation that creates a frameshift in the open reading frame of YPEL3 , leading to an early stop codon. We used zebrafish as a model system to validate that YPEL3 mutations are causative of neuropathy. We found that ypel3 isexpressed in the zebrafish central and peripheral nervous system. Using CRISPR/Cas9 technology, we created zebrafish mutants carrying a genomic lesion similar to that of the patient. Our analysis revealed that Ypel3 is required for specification and migration of myelinating oligodendrocytes, timely exit of the perineurial glial precursors from the central nervous system (CNS), formation of the perineurium, and Schwann cell maturation. Consistent with these observations, zebrafish ypel3 mutants have metabolomic signatures characteristic of oligodendrocyte and Schwann cell differentiation defects, show decreased levels of Myelin basic protein in the central and peripheral nervous system, and develop defasciculated peripheral nerves. Locomotion defects were observed in adult zebrafish ypel3 mutants. These studies demonstrate that Ypel3 is a novel gene required for perineurial cell differentiation and glial myelination.