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Janice L. Huff

Publications and source records attributed to Janice L. Huff.

9 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2024

Integration of the Cardiovascular Risk Model Astro-CHARM in the NASA Radiation Risk Model

Space radiation poses an increased risk for cardiovascular diseases (CVD) during and after spaceflight, that should be quantified to plan future space missions such as the flight to Mars. The radiation-induced CVD risk is evaluated using a linear no-threshold dose response excess relative risk (ERR) model, so that the risk is function of the radiation dose and of the background (i.e., non-exposed) incidence rate. The background CVD risk can be evaluated using clinical prediction models (CPMs). The first CPMs developed in the 1960’s have identified CVD risk factors such as blood pressure, diabetes, cholesterol, and smoking. In this work, the steps used to integrate the CVD risk provided by a CPM into the NASA Radiation Risk Model are described. Simulation results calculated using available data for relevant mission scenarios are also shown, and the challenges in CVD risk predictions are discussed.

Space radiation↗
NASA NTRSDate not supplied

Evaluation of the spaceflight cardiovascular risk using the clinical prediction model Astro-CHARM and the NASA Radiation Risk Model

- Exposure to space radiation may pose a risk for cardiovascular diseases (CVD) during and after spaceflight. - The CVD risk should be quantified to plan future long-duration space missions such as the manned flight to Mars. - Assessing CVD risk is complicated by its multifactorial nature, where an individual’s risk is strongly influenced by risk factors such as family history, blood pressure, and lipid profiles. - In the NASA Space Radiation Risk Model, the metrics of radiation exposure-induced cases (REIC) and radiation exposure-induced death (REID) are used to quantify the risk attributable to radiation over a lifetime after exposure.

Ianik Plante↗
NASA NTRSDate not supplied

Evaluation of the Spaceflight Cardiovascular Disease Risk using the Clinical Prediction Model Astro-Charm and the NASA Radiation Risk Model

Exposure to space radiation and other spaceflight hazards may pose an increased risk for cardiovascular diseases (CVD) during and after spaceflight [1], that should be quantified to plan future long-duration space missions such as the flight to Mars. The first CVD clinical prediction models (CPMs) for individuals were developed by the Framingham Heart Study investigators in the 1960’s. Since then, many CPMs have been developed and refined. The CPMs consider cardiovascular risk factors such as blood pressure, diabetes, cholesterol, and smoking. As there is a relationship between radiation-induced CVD risk and the background (non-exposed) CVD risk, it is possible to use CPMs to calculate a personalized risk for astronauts.

I. Plante↗
NASA NTRSDate not supplied

An Approach to Quantitative Risk Assessment for Combined Spaceflight Hazards: Evaluating the Impact of Short Sleep Durations on Space Crew Cardiovascular Health

Astronauts embarking on long-duration missions will be exposed to multiple spaceflight hazards including radiation, isolation and confinement, distance from Earth, hostile closed environments, and altered gravity. These hazards pose health risks to the crew in-mission and postflight, including risks to cardiovascular health. For radiation, quantitative risk models have been developed that are based on large-scale epidemiological evidence from exposed terrestrial populations, which are extrapolated to account for the difference in radiological effectiveness between ground-based and in-flight exposures. •Cardiovascular diseases (CVD) are multifactorial, therefore multiple risk factors can influence disease risk estimates. •Astronauts with spaceflight experience is a very small population. •To overcome limitations of cohort, population data from presumed equivalent stressors on Earth can be used to quantitatively assess possible risks. •Sleep disruption and short sleep duration are known consequences of spaceflight and are also established risk factors for cardiovascular disease on earth (Pateletal.,2020). •Coronary Heart Disease (CHD), Myocardial Infarction (MI), and stroke are negative health effects due to short sleep durations and sleep disruptions (Yinetal.,2017); (Cappuccio et al., 2010). •A combined CVD risk model including spaceflight stressor such as sleep, stress, radiation, etc.) will provide more precise estimate of risks.

Spaceflight Hazards↗