Engineering topics
Jiang, Hui
Publications and source records attributed to Jiang, Hui.
The SvFUL2 transcription factor is required for inflorescence determinacy and timely flowering in Setaria viridis
Inflorescence architecture in cereal crops directly impacts yield potential through regulation of seed number and harvesting ability. Extensive architectural diversity found in inflorescences of grass species is due to spatial and temporal activity and determinacy of meristems, which control the number and arrangement of branches and flowers, and underlie plasticity. Timing of the floral transition is also intimately associated with inflorescence development and architecture, yet little is known about the intersecting pathways and how they are rewired during development. Here, we show that a single mutation in a gene encoding an AP1/FUL-like MADS-box transcription factor significantly delays flowering time and disrupts multiple levels of meristem determinacy in panicles of the C 4 model panicoid grass, Setaria viridis. Previous reports of AP1/FUL-like genes in cereals have revealed extensive functional redundancy, and in panicoid grasses, no associated inflorescence phenotypes have been described. In S. viridis, perturbation of SvFul2, both through chemical mutagenesis and gene editing, converted a normally determinate inflorescence habit to an indeterminate one, and also repressed determinacy in axillary branch and floral meristems. Our analysis of gene networks connected to disruption of SvFul2 identified regulatory hubs at the intersection of floral transition and inflorescence determinacy, providing insights into the optimization of cereal crop architecture.
Localized enzymolysis and sonochemically modified sunflower protein: Physical, functional and structure attributes
Not Available
High-Pressure Phase Transitions in Densely Packed Nanocrystallites of TiO[subscript 2]-II
Abstract not provided
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules. Degradation of STAT3 protein, therefore, is a promising cancer therapeutic strategy.
Wireless Telemetry and Command (T and C) Program
The Wireless Telemetry and Command (T&C) program is to investigate methods of using commercial telecommunications service providers to support command and telemetry services between a remote user and a base station. While the initial development is based on ground networks, the development is being done with an eye towards future space communications needs. Both NASA and the Air Force have indicated a plan to consider the use of commercial telecommunications providers to support their space missions. To do this, there will need to be an understanding of the requirements and limitations of interfacing with the commercial providers. The eventual payoff will be the reduced operations cost and the ability to tap into commercial services being developed by the commercial networks. This should enable easier realization of EP services to the end points, commercial routing of data, and quicker integration of new services into the space mission operations. Therefore, the ultimate goal of this program is not just to provide wireless radio communications for T&C services but to enhance those services through wireless networking and provider enhancements that come with the networks. In the following chapters, the detailed technical procedure will be showed step by step. Chapter 2 will talk about the general idea of simulation as well as the implementation of data acquisition including sensor array data and GPS data. Chapter 3 will talk about how to use LabVEEW and Component Works to do wireless communication simulation and how to distribute the real-time information over the Internet by using Visual Basic and ActiveX controls. Also talk about the test configuration and validation. Chapter 4 will show the test results both from In-Lab test and Networking Test. Chapter 5 will summarize the whole procedure and give the perspective for the future consideration.