Engineering topics

Jones, Timothy A.

Publications and source records attributed to Jones, Timothy A..

5 records

NASA NTRS2002

Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?

Chronic exposure to increased force environments (+G) has pronounced effects on the circadian and homeostatic regulation of body temperature (T(b)), ambulatory activity (Act), heart rate, feeding, and adiposity. By using the Brn 3.1 knockout mouse, which lacks vestibular hair cells, we recently described a major role of the vestibular system in mediating some of these adaptive responses. The present study used the C57BL6JEi-het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vestibular receptors. In this study, eight het and eight WT mice were exposed to 2G for 8 weeks by means of chronic centrifugation. In addition, eight het and eight WT mice were maintained as 1G controls in similar conditions. Upon 2G exposure, the WT exhibited a decrease in T(b) and an attenuated T(b) circadian rhythm. Act means and rhythms also were attenuated. Body mass and food intake were significantly lower than the 1G controls. After 8 weeks, percent body fat was significantly lower in the WT mice (P < 0.0001). In contrast, the het mice did not exhibit a decrease in mean T(b) and only a slight decrease in T(b) circadian amplitude. het Act levels were attenuated similarly to the WT mice. Body mass and food intake were only slightly attenuated in the het mice, and percent body fat, after 8 weeks, was not different in the 2G het group. These results link the vestibular macular receptors with specific alterations in homeostatic and circadian regulation.

NASA Discipline Regulatory Physiology↗

NASA NTRS2002

Stimulus and recording variables and their effects on mammalian vestibular evoked potentials

Linear vestibular evoked potentials (VsEPs) measure the collective neural activity of the gravity receptor organs in the inner ear that respond to linear acceleration transients. The present study examined the effects of electrode placement, analog filtering, stimulus polarity and stimulus rate on linear VsEP thresholds, latencies and amplitudes recorded from mice. Two electrode-recording montages were evaluated, rostral (forebrain) to 'mastoid' and caudal (cerebellum) to 'mastoid'. VsEP thresholds and peak latencies were identical between the two recording sites; however, peak amplitudes were larger for the caudal recording montage. VsEPs were also affected by filtering. Results suggest optimum high pass filter cutoff at 100-300 Hz, and low pass filter cutoff at 10,000 Hz. To evaluate stimulus rate, linear jerk pulses were presented at 9.2, 16, 25, 40 and 80 Hz. At 80 Hz, mean latencies were longer (0.350-0.450 ms) and mean amplitudes reduced (0.8-1.8 microV) for all response peaks. In 50% of animals, late peaks (P3, N3) disappeared at 80 Hz. The results offer options for VsEP recording protocols. Copyright 2002 Elsevier Science B.V.

Non-NASA Center↗

NASA NTRS1998

Final Report

The specific aims of the research were two fold: 1) to test the working hypothesis that space flight can alter normal development of vestibular sense organs and 2) to characterize adaptation of vestibular receptors to weightlessness and readaptation upon the return to earth. The proposed research has two scientific objectives: 1) In hatchlings (and perhaps embryos): to critically test the hypothesis that space flight can modify the ontogeny of vestibular gravity receptors, and 2) In adult birds: to characterize adaptation of vestibular gravity receptors to weightlessness and further to characterize re-adaptation of vestibular gravity receptors upon their return to earth.

Jones, Timothy A.↗

NASA NTRS1993

Vestibular ontogeny: Measuring the influence of the dynamic environment

In comparison to other special senses, we are only meagerly informed about the development of vestibular function and the mechanisms that may operate to control or influence the course of vestibular ontogeny. Perhaps one contributing factor to this disparity is the difficulty of evaluating vestibular sense organs directly and noninvasively. The present report describes a recently developed direct noninvasive vestibular function test that can be used to address many basic questions about the developing vestibular system. More particularly, the test can be used to examine the effects of the dynamic environment (e.g. gravitational field and vibration) on vestibular ontogeny.

Jones, Timothy A.↗

NASA NTRS1991

Weightlessness and the ontogeny of vestibular function - Evidence for persistent vestibular threshold shifts in chicks incubated in space

The effect of microgravity on the embryonic development of the vestibular function was investigated by comparing the vestibular function parameters measured in 21-old chicks incubated as embryos aboard the Space Shuttle Discovery with those of age-matched synchronous controls incubated on earth. Measurements of the electrophysiological responses in both groups of chicks indicated that the exposure of embryos to weightlessness resulted in altered sensitivity of embryonic vestibular sensors. Moreover, the effect of space flight was persistent: it was still present one month after the spacecraft landed on earth.

Jones, Timothy A.↗