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Jordan, J. P.

Publications and source records attributed to Jordan, J. P..

AUSSAT battery life test program

AUSSAT Pty. Ltd., the Australian National Satellite organization, has contracted with the Hughes Aircraft Company (HAC) for the construction of 3 satellites based on the now familiar HS-376 product line. As part of the AUSSAT contract, HAC is conducting an extensive NiCd battery life test program. The life test program, objectives and test results to date are described. Particular emphasis is given to the evaluation of the FS2117 separator as a future replacement for the Pellon 2505 separator of which only a very limited quantity remains.

Gorian, P. W.↗

Effect of simulated weightlessness on energy metabolism in the rat

Results of measurements of food uptake and body weight changes occurring in rats suspended from a harness so that the antigravity muscles were not used for locomotion are presented. The rats were tested in pairs, with both in a harness but only one suspended off its hind legs; this section lasted 7 days. A second phase of the experiment involved feeding the nonsuspended rat the same amount of food the experimental rat had consumed the previous day. All rats experienced decreased in body weight and food intake in the first stage, while in the second stage the suspended rat lost more weight. The total oxygen uptake, CO2 output, and rate of C-14O2 production were depressed in the suspended rats, then returned to normal levels once the rats were back on the ground. It is concluded that the gross metabolic processes are unaffected by simulated weightlessness.

Jordan, J. P.↗

Simulated weightlessness - Effects on bioenergetic balance

As a prelude to a flight experiment, an attempt was made to separate energy requirements associated with gravity from all other metabolic needs. The biological effects of weightlessness were simulated by suspending animals in a harness so that antigravity muscles were not supporting the body. Twelve pairs of rats were allowed to adapt to wearing a harness for 5 d. Experimental animals were then suspended in harness for 7 d followed by recovery for 7 d. Control animals were harnessed but never suspended. Oxygen consumption, carbon dioxide production and rate of (C-14)O2 expiration from radio-labeled glucose were monitored on selected days. Food intake and body mass were recorded daily. Metabolic rate decreased in experimental animals during 7 d of suspension and returned to normal during recovery. Although some of the metabolic changes may have related to variation in food intake, simulated weightlessness appears to directly affect bioenergetic balance.

Jordan, J. P.↗

An environmental chamber system for prolonged metabolic studies on small animals

Measurement of metabolic adaptation to marginally stressful environments requires both precise regulation of a variety of atmospheric factors for extended periods of time and the capacity to employ sensitive parameters in an undisturbed subject. This paper describes a metabolic chamber system which can simultaneously maintain groups of small animals in two completely separate closed environments having different pressures, temperatures and gas compositions for an indefinite period. Oxygen consumption, carbon dioxide production, food and water consumption and animal activity cycles can be continuously monitored and quantified 24 h per day while the animals are in an unrestrained state. Each chamber can be serviced and the animals handled, injected and sacrificed without subjecting them to barometric stress. Several unique electrical and mechanical components allow semi-automated data collection on a continuous basis for indefinite periods of time.

Jordan, J. P.↗

Nonthermal metabolic response of rats to He-O2, N2-O2, and Ar-O2 at 1 atm.

Experiments were performed to describe qualitatively and quantitatively the nonthermal metabolic response of rats to normoxic mixtures of helium, nitrogen, or argon at 1 atm ambient pressure. Hypoxic mixtures were similarly tested to determine any differences in hypoxic response as a function of the diluent gas. Rats exposed to argon for 5 days had a reduced metabolic rate relative to nitrogen, as evidenced by oxygen and food consumption, CO2 production, and the catabolism of radiosubstrates. While some parameters indicated that helium increased metabolic rate, oxygen consumption did not significantly differ from that in nitrogen. The physiologic and metabolic response to an imposed hypoxia varied among the different environments. Certain indices suggested that the hypoxic effects were less severe in helium and more pronounced in argon than in nitrogen. The mechanisms by which the diluent gases produced the observed changes could not be identified, but some possibilities are discussed.

Schatte, C. L.↗

Metabolic effects of artificial environments

Effects of diluent gases on the metabolism of animals breathing nitrogen-oxygen, argon-oxygen, and helium-oxygen mixtures were studied. Results show that helium actually affected the mean free path of oxygen across the alveoli and increased metabolic rate. It is speculated that it might be necessary to keep an astronaut in a depressed metabolic state during prolonged space flight by using an argon-oxygen or a xenon-nitrogen mixture for breathing. Replacement of the depressant gases during periods requiring critical spacecraft maneuvers by neon-oxygen mixtures would insure maximal performance.

Jordan, J. P.↗

Metabolic effects of artificial environments

The mechanisms by which inert gases influence metabolism were investigated from several viewpoints. Groups of rats were exposed at the thermal neutral temperature of the respective mixtures, to normoxic (P sub A 02 = 100 mm Hq) environments with argon, helium or nitrogen as the diluent at a total pressure of one atmosphere. The possible influence of diluent gases on oxygen transport to the cell was examined with hypoxic (P sub A O2 = 70 mm Hg) mixtures of the same diluent gases. Metabolic measurements included food, water, and oxygen consumption, CO2 production, hematocrit and the rate C-14O2 of expiration subsequent to intraperitoneal injection of acetate-1-C-14 or glucose UL-C-14. Argon-exposed animals showed a consistently decreased metabolic rate while, on the other hand, helium-exposed rats did not significantly alter metabolic rate relative to nitrogen. Certain indices, including acetate and glucose utilization, suggested that helium attenuated the imposed hypoxia at the cellular level while argon facilitated it as compared with nitrogen. These results suggest that metabolic influence of helium is largely thermal in nature while argon has a significant direct metabolic effect and that diluent gases may selectively influence oxygen availability to the interior of the cell.

Jordan, J. P.↗