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The software program “Chemical Equilibrium with Applications” (CEA) is used to solve chemical equilibrium, and compute thermodynamic and transport properties of the resulting mixture, and also has special solvers dedicated to rocket, shock, and detonation problems. We have recently completed a full re-write of CEA with modernization and improvements, called “CEA2022”. In this paper, we will give an overview of CEA2022’s features, and discuss some of the fundamental equations used by CEA2022, as well as the fundamental assumptions, in order to provide users with a complete understanding of the software’s methodology. Several enhancements have been made to the software, including modern software development practices, interface improvements, and additional features. The feature enhancements include: running cases in parallel with thread safe solves, thermodynamic and transport database updates, and allowing for negative and inert reactants. In terms of interface improvements, we have made CEA a reusable library by adding APIs for multiple languages, including Python, Matlab, Excel, Fortran, and C. The subroutine interface allows for integration with other applications, including flow-solver integration (i.e. with CFD). We also compare results between CEA2022 and the previous version (CEA2) as a validation of the new software.