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Kirill Grigorev

Publications and source records attributed to Kirill Grigorev.

12 records
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

NASA GeneLab Multi-study Visualization Portal

NASA GeneLab has helped advance the field of Space Biology by providing a public repository where researchers can store, share, analyze and visualize the results of space flight related omics experiments. The GeneLab data visualization portal allows any user, regardless of bioinformatics knowledge or access to computational resources, to interact with the experimental data, draw their own conclusions, and gain insights about the effects of space on living systems. These tools help democratize scientific research and foster the NASA Open Science initiative. The new multi-study feature of the GeneLab visualization platform allows users to mine study metadata from RNA sequencing (RNA-seq) experiments to identify samples of interest by filtering datasets based on organism, tissue, assay technology type, and/or factor. Once samples are selected from multiple datasets, users can combine and normalize the sample data, then utilize the visualization displays, including Principal Component Analysis (PCA) plots, to assess sample distributions. Finally, users can perform differential gene expression analysis on the combined data and visualize the results through PCA plots, Volcano plots, Pair plots, Heatmap, Ideogram and Gene Set Enrichment Analysis. All user-generated results and visualizations will be available for download. Here, we present a biological study using samples from multiple GeneLab RNA-seq datasets and analyzed using the multi-study visualization platform to demonstrate inter- and intra-study variability, as well as commonly differentially expressed genes between spaceflight and ground control conditions across datasets. This new feature opens a wide range of possibilities and opportunities for further development including combining other assay technology types and integration with batch effect correction techniques and machine learning applications. Overall, this tool allows users to increase the statistical power of individual experiments, validate hypothesis, identify patterns, and opens the door to new and exciting research.

space biology↗
NASA NTRSDate not supplied

RadLab and the Environmental Data Application Dashboard: Graphical and Programming Interfaces for Interrogation of Space Telemetry Data

Sensors on the International Space Station (ISS) and multiple spacecraft elsewhere in Earth orbit and in deep space continuously monitor and collect environmental data, transmitting this information back to Earth. These data include ionizing radiation and, on the ISS, CO2, relative humidity levels, and temperature, and are of great importance to space biology research. Ionizing radiation in particular has been established in ground-based experiments as being correlated with increased risk of carcinogenesis and cardiovascular and neurological effects. Looking ahead to future long duration crewed missions beyond low Earth orbit, the ability to study how factors including CO2 levels, light cycle, temperature modulate the response to ionizing radiation and microgravity is essential. To date, access to these data has been fragmented across space agencies, spacecraft, and databases. To address this issue, NASA’s Open Science Data Repository (osdr.nasa.gov) has developed two Web applications: the Environmental Data Application (EDA) and a radiation-specific RadLab. Each consists of an API (application programming interface) and an associated GUI (graphical user interface) that provide single points of access to the data. To date, OSDR has focused on the sensors from payloads and radiation detectors located on the ISS. The Web applications process telemetry information and associated data, such as spacecraft location and orientation, from multiple international databases. The applications’ request syntax enables users to interrogate these data by craft, sensor type, time range, radiation type (galactic cosmic rays, solar particle events, the contribution of the South Atlantic Anomaly), facilitating arbitrary comparisons of original source data at varying time resolutions. The applications provide programmatic access for use in computational pipelines and GUIs for data visualization and exploration, making these data FAIR (Findable, Accessible, Interoperable, and Reusable), complementing the biological data contained in OSDR, and providing the space science community with a valuable resource for scientific analyses.

radiation↗
NASA NTRSDate not supplied

RadLab Platform: Investigating Space Radiation

The RadLab Project, initiated by the Open Science Data Repository (OSDR) for Space Biology at NASA Ames Research Center (osdr.nasa.gov), aims to be an ongoing compilation of radiation data relevant to human space flight. Sponsored by the NASA Human Research Program, RadLab serves as the latest database in this domain. RadLab is intended to serve the needs of both the space radiation detector and space radiation biology communities. The RadLab architecture is being designed to accommodate data both from low Earth orbit (LEO) and beyond low Earth orbit (BLEO). Our long-term vision entails the establishment of a sustainable database receiving continuous updates through APIs connecting to other databases, as well as individual investigator contributions via a RadLab submission portal, modeled on the OSDR (https://osdr.nasa.gov/bio/submission-sso-login.html). In addition to serving as a resource for space biologists and space radiation physicists, such a database would facilitate the deployment of AI algorithms to study the impact of location in space and within spacecraft on the ambient space radiation field. The ultimate goal is to develop predictive dosimetry algorithms for future BLEO missions.

Sylvain V Costes↗
NASA NTRSDate not supplied

RadLab: Graphical and Programming Interfaces for Interrogation of Space Telemetry Data

Sensors on multiple spacecraft in and beyond low Earth orbit continuously monitor and collect space radiation data and transmit it back to Earth. These data are of vast importance to space biology research, as ionizing radiation affects living organisms—astronauts and non-human experiment subjects alike—placing them at higher risk of carcinogenesis, degenerative diseases, and radiation sickness. Therefore, knowledge of the biological effects of space radiation is essential for planning future crewed missions beyond low Earth orbit. The RadLab project, initiated by GeneLab and ALSDA (the Open Science Data Repository; OSDR) and sponsored by the NASA Human Research Program, is a new effort aimed at connecting dosimetry data from radiation detectors located on the International Space Station (ISS), as well as other spacecraft. To date, access to these data has been fragmented across space agencies and databases; to address this issue, we have developed an application programming interface (API) and an associated graphical user interface (GUI) designed to provide a single point of access to the data. As of now, OSDR has focused on the detectors located on the ISS, with the long-term goal to establish a self-sustained portal receiving continuous updates through APIs connecting to multiple radiation databases of varying scope, as well as individual investigator contributions. The RadLab API implements a request syntax enabling users to query data by craft, sensor type, timespan, etc, allowing for arbitrary combinations of original source data, thus providing programmatic access for use in computational pipelines, while the GUI facilitates data visualization and exploration, making these data FAIR (Findable, Accessible, Interoperable, and Reusable), complementing the biological data contained in OSDR, and providing the space science community with a valuable resource for scientific analyses.

radiation↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Graphical and Programming Interfaces for Biologically Relevant Space Radiation Data

RadLab, a new component of the NASA Open Science Data Repository (OSDR), is a platform built upon a database of radiation data relevant to space biology. RadLab provides visual and programmatic interfaces for interrogation of its database, as well as a submission process for inclusion of data from investigators. The RadLab application programming interface (API) implements a request syntax enabling users to retrieve data filtered by various combinations of parameters (detector type, location, direction, timespan, etc), which are delivered in machine-readable text formats, ready to be ingested by downstream analysis pipelines; while the graphical user interface (GUI) provides easy means to iteratively modify query parameters and incorporates a number of standard analyses and visualizations (time series plots, geospatial visualizations, detector comparison). Investigators from many countries, including US, Russia, Japan, Canada, the Czech Republic, Germany, Hungary, and Italy, have committed to provide data from their instruments located on the ISS; RadLab will also include data from other spacecraft in LEO (e.g., the Space Shuttle, the Mir space station), BLEO (e. g. BioSentinel, Mars Orbiter, among others), and on other celestial bodies (e. g. Chang’e 4, Curiosity). The first release of RadLab has been made available to the public. Once fully operational, RadLab will provide a comprehensive and ever-growing compendium of space radiation data, facilitating straightforward access to multiple types of readings and enabling space biology researchers to perform intercomparisons of detectors and to determine the radiation environment of research missions, both via programmatic retrieval of these data and via the graphical analysis toolkit; as well as a user-friendly submission portal for ingesting data from space agencies and research institutions. Radiation scientists will be able to use RadLab to gain a deeper understanding of the space radiation environment for future human space exploration. The RadLab Working Group has been formed to foster close collaborations among data contributors and users, to identify data sources, to put in place standards for data normalization, to guide the development of features of the analysis toolkit, to establish the use of RadLab in space radiation biology research, and eventually to provide a forum for discussing relevant research issues that can take advantage of RadLab's capabilities.

radiation↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Analysis Toolkit for Space Radiation Measurements Relevant to Space Radiation Biology

RadLab, a new addition to the NASA Open Science Data Repository (OSDR), is a public platform for space radiation data relevant to human space exploration. RadLab consists of a database, a submission portal, and user-friendly visualization and data analysis tools, including a graphical user interface (GUI) and an application programming interface (API). Investigators from ISS partners including Germany, Italy, Canada, Hungary, the Czech Republic, Russia, Japan have committed to providing data from their instruments. RadLab will also include data from other spacecraft in LEO: the Space Shuttle, the Mir space station, biosatellites; and beyond LEO: the lunar and the Martian surface, the heliocentric orbit at 1 AU, Mars orbit, and Earth-Mars space. Once fully operational, RadLab will provide open, centralized access to space radiation physics data relevant to human space exploration; a platform for submission of data by agencies and research institutions responsible for radiation detectors deployed in space; analysis tools to facilitate detector and dataset intercomparison to better understand space habitat radiation environments; capabilities for space biology investigators to determine the radiation environment to which samples were exposed. A RadLab Working Group (RLWG) has been formed, modeled on the GeneLab Analysis Working Groups and comprised of data contributors and users. RLWG tasks include identifying data sources, normalizing data from diverse detectors, expanding the analysis toolkit and, perhaps most importantly, sharing ideas for research exploiting capabilities of RadLab. We will provide an overview of RadLab data and capabilities and discuss examples of its potential as a resource for open science.

radiation↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Graphical and Programming Interfaces for Biologically Relevant Space Radiation Data

RadLab, a new component of the NASA Open Science Data Repository (OSDR), comprises a database of radiation measurements relevant to space biology, and visual and programmatic interfaces for interrogation and retrieval of these data. The attributes of data available through RadLab include spacecraft, types of radiation sensing instruments, locations within the spacecraft (e.g. modules of the ISS), associated celestial bodies, trajectories, and spacecraft coordinates. The application programming interface (API) implements a request syntax for retrieval of timestamped data filtered by various combinations of such attributes; the graphical user interface (GUI) extends this functionality with visualizations, such as spacecraft schematics, time series plots, geospatial visualizations, and provides easy means to iteratively refine search parameters, inspect the data on the fly, and download target subsets of these data. The release of RadLab currently available to the public contains datasets provided by US and international collaborators and focuses on data recorded on the ISS. Investigators from multiple countries, including the US, Canada, Germany, Bulgaria, Hungary, Italy, Japan, Russia and the Czech Republic, have committed to provide data from their instruments in and beyond low Earth orbit; RadLab will also soon expand to include past (e.g. Shuttle and Mir) and future (e.g. Artemis) data. RadLab will provide a comprehensive, dynamic compendium of space radiation data, enabling the scientific community to perform analyses of data from multiple detectors and to determine the radiation environment of research missions and experiments, both via programmatic retrieval of these data and through the graphical analysis toolkit. The RadLab Working Group has been formed to foster collaborations among data contributors and users, to identify data sources, to put in place standards for data harmonization, and to guide the development of the platform, with the goal to establish the use of RadLab in space radiation research and to advance our understanding of the space radiation environment in human habitats.

radiation↗
NASA NTRSDate not supplied

The Environmental Data Application for Analysis of Space Telemetry Data

Sensors on the International Space Station (ISS) and multiple spacecraft elsewhere in Earth orbit and in deep space continuously monitor and collect environmental data, transmitting this information back to Earth. These data include ionizing radiation and, on the ISS and spacecrafts, CO2, relative humidity levels, and temperature, and are of great importance to space biology research. Looking ahead to future long duration crewed missions beyond low Earth orbit, the ability to study how factors including CO2 levels, light cycle, temperature modulate the response to ionizing radiation and microgravity is essential. To date, access to these data has been fragmented across space agencies, spacecraft, and databases. To address this issue, NASA’s Open Science Data Repository (OSDR) has developed a user interface for interrogation of telemetry data: the Environmental Data Application (EDA). The EDA provides the capability to visualize telemetry and radiation data collected on the International Space Station and corresponding ground platforms during the Rodent Research missions. Telemetry data includes temperature, relative humidity, and CO2 levels. Radiation data includes galactic cosmic rays, the contribution of the South Atlantic Anomaly, total radiation dose rate, and accumulated radiation dose. The application allows users to view single missions, compare multiple missions, and view and download summary or full data tables. In summary, the EDA provides GUIs for data visualization and exploration, as well as means for data export, making these data FAIR (Findable, Accessible, Interoperable, and Reusable), complementing the biological data contained in OSDR, and providing the space science community with a valuable resource for scientific analyses.

telemetry↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Graphical and Programming Interfaces for Space Radiation Data

RadLab, a component of the NASA Open Science Data Repository (OSDR), is a database of radiation measurements from multiple instruments and spacecraft that provides visual and programmatic interfaces for interrogation and retrieval of these data. The attributes of data available through RadLab include spacecraft, types of radiation sensing instruments, locations within the spacecraft (e.g. ISS modules), associated celestial bodies, trajectories, and spacecraft coordinates; the primary type of data is the absorbed dose rate, as well as flux and dose equivalent rate where available. The application programming interface (API) implements a request syntax for retrieval of timestamped data filtered by various combinations of such attributes; the graphical user interface (GUI) extends this functionality with visualizations (time series plots, comparison plots, geospatial visualizations) which provide easy means to assess data availability, iteratively refine search parameters, interactively inspect the data, and export target data subsets. Datasets are continuously being added to the RadLab database as part of the rolling release process. Investigators from multiple countries, including the US, Canada, Germany, Bulgaria, Hungary, Italy, Japan, Russia and the Czech Republic, have committed to provide data from their instruments in and beyond low Earth orbit. The current release contains datasets provided by US and international collaborators and includes readings from multiple modules of the ISS, the BioSentinel CubeSat, Chang’e 4, the Lunar Reconnaissance Orbiter, the ExoMars Orbiter, and the Curiosity rover. Datasets are associated with respective RadLab knowledgebase articles which include instrument descriptions and provide bibliographical references. RadLab aims to provide a comprehensive, dynamic compendium of space radiation data, enabling the scientific community to perform analyses of data from multiple detectors and to determine the radiation environment of research missions and experiments. Some of its applications include inference of absorbed radiation dose for NASA GeneLab payloads, and training predictive models as part of the 2024 FDL-X challenge. The platform is actively expanding and seeking additional data, with plans to also cover past (e.g. Shuttle, Mir) and future (e.g. Artemis) missions. The RadLab Working Group has been created to aid in this process as well as to foster collaborations among data contributors and users, to develop standards for data harmonization, and to guide the development of the platform, with the goal to establish the use of RadLab in space radiation research and to advance our understanding of the radiation environment in outer space.

Kirill Grigorev↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Graphical and Programming Interfaces for Biologically Relevant Space Radiation Data

RadLab, a new component of the NASA Open Science Data Repository (OSDR), comprises a database of radiation measurements relevant to space biology, and visual and programmatic interfaces for interrogation and retrieval of these data. The attributes of data available through RadLab include spacecraft, types of radiation sensing instruments, locations within the spacecraft (e.g. modules of the ISS), associated celestial bodies, trajectories, and spacecraft coordinates. The application programming interface (API) implements a request syntax for retrieval of timestamped data filtered by various combinations of such attributes; the graphical user interface (GUI) extends this functionality with visualizations, such as spacecraft schematics, time series plots, geospatial visualizations, and provides easy means to iteratively refine search parameters, inspect the data on the fly, and download target subsets. The release of RadLab currently available to the public contains datasets provided by US and international collaborators and focuses on data recorded on the ISS. Investigators from multiple countries, including the US, Canada, Germany, Bulgaria, Hungary, Italy, Japan, Russia and the Czech Republic, have committed to provide data from their instruments in and beyond low Earth orbit; RadLab will also soon expand to include past (e.g. Shuttle and Mir) and future (e.g. Artemis) data. RadLab will provide a comprehensive, dynamic compendium of space radiation data, enabling the scientific community to perform analyses of data from multiple detectors and to determine the radiation environment of research missions and experiments. The RadLab Working Group has been formed to foster collaborations among data contributors and users, to identify data sources, to put in place standards for data harmonization, and to guide the development of the platform, with the goal to establish the use of RadLab in space radiation research and to advance our understanding of the space radiation environment in human habitats.

database↗
NASA NTRSDate not supplied

RadLab: A Comprehensive Database and Graphical and Programming Interfaces for Space Radiation Data

RadLab, a component of the NASA Open Science Data Repository (OSDR), is a database of radiation measurements from multiple instruments and spacecraft that provides visual and programmatic interfaces for interrogation and retrieval of these data. The attributes of data available through RadLab include spacecraft, types of radiation sensing instruments, locations within the spacecraft (e.g. ISS modules), associated celestial bodies, trajectories, and spacecraft coordinates; the primary type of data is the absorbed dose rate, as well as flux and dose equivalent rate where available. The application programming interface (API) implements a request syntax for retrieval of timestamped data filtered by various combinations of such attributes; the graphical user interface (GUI) extends this functionality with visualizations (time series plots, comparison plots, geospatial visualizations) which provide easy means to assess data availability, iteratively refine search parameters, interactively inspect the data, and export target data subsets. Datasets are continuously being added to the RadLab database as part of the rolling release process. Investigators from multiple countries, including the US, Canada, Germany, Bulgaria, Hungary, Italy, Japan, Russia and the Czech Republic, have committed to provide data from their instruments in and beyond low Earth orbit. The current release contains datasets provided by US and international collaborators and includes readings from multiple modules of the ISS, the BioSentinel CubeSat, Chang’e 4, the Lunar Reconnaissance Orbiter, the ExoMars Orbiter, and the Curiosity rover. Datasets are associated with respective RadLab knowledgebase articles which include instrument descriptions and provide bibliographical references. RadLab aims to provide a comprehensive, dynamic compendium of space radiation data, enabling the scientific community to perform analyses of data from multiple detectors and to determine the radiation environment of research missions and experiments. Some of its applications include inference of absorbed radiation dose for NASA GeneLab payloads, and training predictive models as part of the 2024 FDL-X challenge. The platform is actively expanding and seeking additional data, with plans to also cover past (e.g. Shuttle, Mir) and future (e.g. Artemis) missions. The RadLab Working Group has been created to aid in this process as well as to foster collaborations among data contributors and users, to develop standards for data harmonization, and to guide the development of the platform, with the goal to establish the use of RadLab in space radiation research and to advance our understanding of the radiation environment in outer space.

Kirill Grigorev↗