Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Abstract not provided
Bain, G.↗
Engineering topics
Lai, A.
Publications and source records attributed to Lai, A..
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. The MTAP gene is frequently deleted in human cancers because of its chromosomal proximity to the tumor suppressor gene CDKN2A. By interrogating data from a large-scale short hairpin RNA–mediated screen across 390 cancer cell line models, we found that the viability of MTAP-deficient cancer cells is impaired by depletion of the protein arginine methyltransferase PRMT5. MTAP-deleted cells accumulate the metabolite methylthioadenosine (MTA), which we found to inhibit PRMT5 methyltransferase activity. Deletion of MTAP in MTAP-proficient cells rendered them sensitive to PRMT5 depletion. Conversely, reconstitution of MTAP in an MTAP-deficient cell line rescued PRMT5 dependence. Thus, MTA accumulation in MTAP–deleted cancers creates a hypomorphic PRMT5 state that is selectively sensitized toward further PRMT5 inhibition. Inhibitors of PRMT5 that leverage this dysregulated metabolic state merit further investigation as a potential therapy for MTAP/CDKN2A-deleted tumors.
59 BASIC BIOLOGICAL SCIENCES↗
The Development of the Low Temperature Microgravity Physics Facility
We describe the design and development of the Low Temperature Microgravity Physics Facility, which is intended to provide long duration (4.5 months) low temperature (1.4K) and microgravity conditions for scientists to perform breakthrough investigations on board the International Space Station.
Low Temperature Fundamental Physics Microgravity P↗
Electronics Design for the Low Temperature Microgravity Physics Facility in the Space Station Environment
Explore the source record for details and available documents.
electronics extreme space environment space statio↗
The Low Temperature Microgravity Physics Facility Project
We describe the design and development of the Low Temperature Microgravity Physics Facility, which is intended to provide a unique environment of low temperature and microgravity for the scientists to perform breakthrough investigations on board the International Space Station.
Low Temperature Microgravity Space ISS↗
New Planetary Rovers for Long Range Mars Science and Sample Return
There are significant international efforts underway to place mobile robots (rovers) on the surface of Mars.
sample return planetary science↗
Multiple-mission telemetry
Progress report, block diagrams, and processing of multiple-mission telemetry of Deep Space Instrumentation Facility
Frey, W.↗