Radiation Shielding of Electronic Circuits
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radiation shielding, electronic circuit boards, sp↗
Engineering topics
Lee, Daniel
Publications and source records attributed to Lee, Daniel.
Cell surface crowding is a tunable energetic barrier to cell-cell fusion
Abstract Cell-cell fusion is fundamental to processes such as muscle formation and viral infection. An essential step in fusion is close membrane apposition, but cell membranes are crowded with proteins, glycoproteins, and glycolipids, which must be cleared before a fusion pore can be nucleated. Here, we find that cell surface crowding reduces fusogenicity independent of how fusion is driven. We estimate that crowding presents an energetic barrier to membrane apposition on the scale of ~$${100k}_{{\mbox{B}}}T$$ 100 k B T , greater than that of bare membrane fusion alone. We show that increasing cell surface crowding reduces fusion efficiency of PEG-mediated and fusogen-mediated cell-cell fusion, as well as synthetic membranes under force. Interestingly, we find that differentiating myoblasts naturally decrease their surface crowding prior to fusion. In this work, we show that cell surface crowding presents an underappreciated biophysical barrier that may be tuned developmentally and could be targeted externally to control tissue-specific cell-cell fusion.
Science & Technology - Other Topics↗
SERVIR: From Space to Village. A Regional Monitoring and Visualization System For Environmental Management Using Satellite Applications For Sustainable Development
NASA is committed to providing technological support and expertise to regional and national organizations for earth science monitoring and analysis. This commitment is exemplified by NASA's long-term relationship with Central America. The focus of these efforts has primarily been to measure the impact of human development on the environment and to provide data for the management of human settlement and expansion in the region. Now, NASA is planning to extend and expand this capability to other regions of the world including Africa and the Caribbean. NASA began using satellite imagery over twenty-five years ago to locate important Maya archeological sites in Mesoamerica and to quantify the affect of deforestation on those sites. Continuing that mission, NASA has partnered with the U.S. Agency for International Development (USAID), the World Bank, the Water Center for the Humid Tropics of Latin America and the Caribbean (CATHALAC) and the Central American Commission for Environment and Development (CCAD) to develop SERVIR (Sistema Regional de Visualizacion y Monitoreo), for the Mesoamerican Biological Corridor. SERVIR has become one of the most important aspects of NASA's geospatial efforts in Central America by establishing a common access portal for information that affects the lives, livelihood and future of everyone in the region. SERVIR, most commonly referred to as a regional visualization and monitoring system, is a scientific and technological platform that integrates satellite and other geospatial data sets to generate tools for improved decision-making capabilities. It has a collection of data and models that are easily accessible to earth science managers, first responders, NGO's (Non-Government Organizations) and a host of others. SERVIR is currently used to monitor and forecast ecological changes as well as provide information for decision support during severe events such as forest fires, red tides,and tropical storms. Additionally, SERVIR addresses the nine societal benefit areas of the Global Earth Observation System (GEOSS): disasters, ecosystems, biodiversity, weather, water, climate, health, agriculture and energy.
Sever, Tom↗
Advanced Software Development Workstation Project
The Advanced Software Development Workstation Project, funded by Johnson Space Center, is investigating knowledge-based techniques for software reuse in NASA software development projects. Two prototypes have been demonstrated and a third is now in development. The approach is to build a foundation that provides passive reuse support, add a layer that uses domain-independent programming knowledge, add a layer that supports the acquisition of domain-specific programming knowledge to provide active support, and enhance maintainability and modifiability through an object-oriented approach. The development of new application software would use specification-by-reformulation, based on a cognitive theory of retrieval from very long-term memory in humans, and using an Ada code library and an object base. Current tasks include enhancements to the knowledge representation of Ada packages and abstract data types, extensions to support Ada package instantiation knowledge acquisition, integration with Ada compilers and relational databases, enhancements to the graphical user interface, and demonstration of the system with a NASA contractor-developed trajectory simulation package. Future work will focus on investigating issues involving scale-up and integration.
Lee, Daniel↗