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Leland S. Stone

Publications and source records attributed to Leland S. Stone.

3 records
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Saccade-Pursuit Coordination during Ocular Tracking across Different Impairment Sources

Purpose: Sleep loss and alcohol have been shown to impair smooth pursuit and its underlying visual motion processing in humans. This study examines the saccadic compensation for this poor pursuit. Methods: Using an established behavioral ocular-tracking paradigm (Liston & Stone, 2014, doi:10.1167/14.14.12), we examined the dose-response of ground lost (pursuit deficit integrated across our 300-ms steady-state tracking interval) and ground gained (increased saccadic response harnessed to compensate)across three separate studies – acute low-dose alcohol administration (LDA; n = 16 subjects), acute sleep loss(ASL; n = 12), and chronic sleep restriction (CSR; n = 12). We computed dose-responses as the linear regression slopes of ground lost and gained across treatment dose (% blood alcohol concentration [BAC] or hours awake). For the CSR study, we computed the mean effect for a single dose (5-hours nightly sleep for 1week). Results: For LDA, there was significantly increased ground lost (P < 0.001) and gained (P < 0.001) with increased %BAC. In addition, the dose-responses were not significantly different (P = 0.35), indicating effectively complete saccadic compensation due to significant increases in both saccadic rate (P < 0.05) and amplitude (P < 0.001). For ASL, there was significantly increased ground lost with time awake (P < 0.01),however ground gained was significantly lower (P < 0.001), indicating, at best, incomplete compensation due to a significant increase in saccadic rate (P < 0.001) but not amplitude (P = 0.10). With CSR, pursuit was again significantly impaired (P < 0.05), with saccadic rate significantly increased (P < 0.05) but, surprisingly, amplitude was significantly decreased (P < 0.05), effectively eliminating ground gained (P = 0.90). Conclusions: Our analyses show that LDA, ASL, and CSR affect tracking differently, suggesting the involvement of different brain pathways. With LDA, the effect appears largely due to the cortical impairment of visual motion processing with largely healthy brainstem and mid-brain responses (driving effective saccadic compensation). ASL and CSR however appear to affect both cortical and sub-cortical pathways, with at best partial saccadic compensation. Lastly, CSR is associated with an additional compromise due to a maladaptive decrease in saccade amplitude.

saccade↗
NASA NTRSDate not supplied

An Oculometric Standard to Assess the Performance of the Ocular System for Long Duration Spaceflight

Changes in the human brain, due to spaceflight, have been a challenge to the space program since its inception; a challenge that is becoming more acute as extended International Space Station (ISS) missions become routine, a return to crewed lunar exploration is about to begin, and a multi-year crewed trip to Mars is being planned. Determining the extent to which neurophysiological adaptations may adversely impact performance in operational tasks, assessing the full-time course of these changes, and identifying/mitigating any potential long-term health consequences are crucial steps required to enable safe crew-autonomous, long-duration, deep-space missions. Vision is the predominant perceptual sense used to guide cognition and motor control in humans. Thus, it is critical for the success of any future, long-duration mission to understand how long-term exposure to microgravity and to other stressors of spaceflight and their interactions, impact visual function. This is an especially challenging task given the small and disparate samples from which we have been and will be able to collect human performance data. NASA has recently been carefully tracking spaceflight-induced ophthalmic changes, driven in large part by the fluid shifts related to microgravity. In particular, a recent study of Optical Coherence Tomography (OCT) postflight measures revealed that more than two-thirds of US crew members experience significant increases in retinal thickness after 6month or longer ISS missions. Space Associated Neuro-ocular Syndrome (SANS) also includes visual acuity decrements and other ocular structural changes that could adversely impact in-flight performance as missions become longer. However, the impact of spaceflight on the visual system is not limited to the retina. Recent comparisons of pre-and post-flight brain images have revealed structural changes throughout the brain that implicate visual, visuomotor, and visual-cognitive pathways, consistent with observed functional impacts (e.g., decreased speed/accuracy/timing of fine goal-oriented movements). Current limitations on inflight testing make it very difficult to determine when and under what conditions SANS and other disruptions of human neurological subsystems arise. Currently, one cannot anticipate the time course and extent of impairment and recovery. This study addresses this knowledge gap by creating an integrated framework of the relevant existing literature on visual and oculomotor function during spaceflight with an eye towards complementing current structural measures of visuomotor impairment with new oculometric standard measures. Using eye-movement based visual function assessment and diagnostics would provide a valuable enhancement of crew health and performance monitoring in support of deepspace exploration.

Vision↗