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Leuze, Michael Rex

Publications and source records attributed to Leuze, Michael Rex.

DNA2FACE: An approach to correlating 3D facial structure and DNA

In this paper we introduce the concept of correlating genetic variations in an individual's specific genetic code (DNA) and facial morphology. This is the first step in the research effort to estimate facial appearance from DNA samples, which is gaining momentum within intelligence, law enforcement and national security communities. The dataset for the study consisting of genetic data and 3D facial scans (phenotype) data was obtained through the FaceBase Consortium. The proposed approach has three main steps: phenotype feature extraction from 3D face images, genotype feature extraction from a DNA sample, and genome-wide association analysis to determine genetic variations that contribute to facial structure and appearance. Results indicate that there exist significant correlations between genetic information and facial structure. We have identified 30 single nucleotide polymorphisms (SNPs), i.e. genetic variations, that significantly contribute to facial structure and appearance. We conclude with a preliminary attempt at facial reconstruction from the genetic data and emphasize on the complexity of the problem and the challenges encountered.

Srinivas, Nisha↗

Creating a Face from a DNA Sample

The idea of creating a recognizable face from a sample of DNA is moving closer to reality as Oak Ridge National Laboratory (ORNL) researchers employ a novel statistical representation of the face and a genome-wide association study (GWAS) to relate facial characteristics to genetic mutations. The reduction in cost of DNA sequencing and genotyping technology is leading to the availability of massive datasets of human genome sequences and human genotypes representing mutational variation among people. These large-scale data provide for the first time the potential to correlate an individual’s specific genetic code with their physical appearance. Using a specialized statistical method for representing the entire 3D shape of faces, ORNL researchers performed a GWAS to discover associations between genetic mutations and aspects of face shape. Data from 3,556 subjects resulted in the discovery of a very large set of statistically significant associations, which is strong evidence for the viability of predicting faces from DNA.

59 BASIC BIOLOGICAL SCIENCES↗