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Lin, W.

Publications and source records attributed to Lin, W..

At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

Abstract MUTYH is a clinically important DNA glycosylase that thwarts mutations by initiating base-excision repair at 8-oxoguanine (OG):A lesions. The roles for its [4Fe-4S] cofactor in DNA repair remain enigmatic. Functional profiling of cancer-associated variants near the [4Fe-4S] cofactor reveals that most variations abrogate both retention of the cofactor and enzyme activity. Surprisingly, R241Q and N238S retained the metal cluster and bound substrate DNA tightly, but were completely inactive. We determine the crystal structure of human MUTYH bound to a transition state mimic and this shows that Arg241 and Asn238 build an H-bond network connecting the [4Fe-4S] cluster to the catalytic Asp236 that mediates base excision. The structure of the bacterial MutY variant R149Q, along with molecular dynamics simulations of the human enzyme, support a model in which the cofactor functions to position and activate the catalytic Asp. These results suggest that allosteric cross-talk between the DNA binding [4Fe-4S] cofactor and the base excision site of MUTYH regulate its DNA repair function.

Science & Technology - Other Topics↗
NASA NTRS2018

Evaluation of Multiple Doppler Retrievals of Convection in Darwin

Climate Model Development and Validation: (1) DOE's E3SM model being developed with goal of an increased resolution of 13 km (right arrow) assumptions made in convective parameterizations may not apply. (2) Need long term dataset with quantifiable large scale forcings to evaluate performance of convective parameterizations. (3) Vertical velocities are critical for calculating mass fluxes but are poorly represented in GCMs. (4) Dual Doppler techniques can retrieve vertical velocities, but uncertainties can be high due to sampling, mass continuity assumptions, fall speed assumptions, boundary conditions. (5) Can use high-resolution model simulated radar variables to assess impacts of such uncertainties

Doppler↗
NASA NTRS2001

Ultrasonic wave propagation in trabecular bone predicted by the stratified model

The objective of this study was to investigate ultrasound propagation in trabecular bone by considering the wave reflection and transmission in a multilayered medium. The use of ultrasound to identify those at risk of osteoporosis is a promising diagnostic method providing a measure of bone mineral density (BMD). A stratified model was proposed to study the effect of transmission and reflection of ultrasound wave within the trabecular architecture on the relationship between ultrasound and BMD. The results demonstrated that ultrasound velocity in trabecular bone was highly correlated with the bone apparent density (r=0.97). Moreover, a consistent pattern of the frequency dependence of ultrasound attenuation coefficient has been observed between simulation using this model and experimental measurement of trabecular bone. The normalized broadband ultrasound attenuation (nBUA) derived from the simulation results revealed that nBUA was nonlinear with respect to trabecular porosity and BMD. The curve of the relationship between nBUA and BMD was parabolic in shape, and the peak magnitude of nBUA was observed at approximately 60% of bone porosity. These results agreed with the published experimental data and demonstrated that according to the stratified model, reflection and transmission were important factors in the ultrasonic propagation through the trabecular bone.

Non-NASA Center↗
NASA NTRS2001

Computational Aeroacoustic Analysis System Development

Many industrial and commercial products operate in a dynamic flow environment and the aerodynamically generated noise has become a very important factor in the design of these products. In light of the importance in characterizing this dynamic environment, Rocketdyne has initiated a multiyear effort to develop an advanced general-purpose Computational Aeroacoustic Analysis System (CAAS) to address these issues. This system will provide a high fidelity predictive capability for aeroacoustic design and analysis. The numerical platform is able to provide high temporal and spatial accuracy that is required for aeroacoustic calculations through the development of a high order spectral element numerical algorithm. The analysis system is integrated with well-established CAE tools, such as a graphical user interface (GUI) through PATRAN, to provide cost-effective access to all of the necessary tools. These include preprocessing (geometry import, grid generation and boundary condition specification), code set up (problem specification, user parameter definition, etc.), and postprocessing. The purpose of the present paper is to assess the feasibility of such a system and to demonstrate the efficiency and accuracy of the numerical algorithm through numerical examples. Computations of vortex shedding noise were carried out in the context of a two-dimensional low Mach number turbulent flow past a square cylinder. The computational aeroacoustic approach that is used in CAAS relies on coupling a base flow solver to the acoustic solver throughout a computational cycle. The unsteady fluid motion, which is responsible for both the generation and propagation of acoustic waves, is calculated using a high order flow solver. The results of the flow field are then passed to the acoustic solver through an interpolator to map the field values into the acoustic grid. The acoustic field, which is governed by the linearized Euler equations, is then calculated using the flow results computed from the flow solver.

Hadid, A.↗
NASA NTRS1995

The trellis complexity of convolutional codes

It has long been known that convolutional codes have a natural, regular trellis structure that facilitates the implementation of Viterbi's algorithm. It has gradually become apparent that linear block codes also have a natural, though not in general a regular, 'minimal' trellis structure, which allows them to be decoded with a Viterbi-like algorithm. In both cases, the complexity of the Viterbi decoding algorithm can be accurately estimated by the number of trellis edges per encoded bit. It would, therefore, appear that we are in a good position to make a fair comparison of the Viterbi decoding complexity of block and convolutional codes. Unfortunately, however, this comparison is somewhat muddled by the fact that some convolutional codes, the punctured convolutional codes, are known to have trellis representations that are significantly less complex than the conventional trellis. In other words, the conventional trellis representation for a convolutional code may not be the minimal trellis representation. Thus, ironically, at present we seem to know more about the minimal trellis representation for block than for convolutional codes. In this article, we provide a remedy, by developing a theory of minimal trellises for convolutional codes. (A similar theory has recently been given by Sidorenko and Zyablov). This allows us to make a direct performance-complexity comparison for block and convolutional codes. A by-product of our work is an algorithm for choosing, from among all generator matrices for a given convolutional code, what we call a trellis-minimal generator matrix, from which the minimal trellis for the code can be directly constructed. Another by-product is that, in the new theory, punctured convolutional codes no longer appear as a special class, but simply as high-rate convolutional codes whose trellis complexity is unexpectedly small.

Mceliece, R. J.↗
NASA NTRS1995

Minimal trellises for linear block codes and their duals

We consider the problem of finding a trellis for a linear block code that minimizes one or more measures of trellis complexity for a fixed permutation of the code. We examine constraints on trellises, including relationships between the minimal trellis of a code and that of the dual code. We identify the primitive structures that can appear in a minimal trellis and relate this to those for the minimal trellis of the dual code.

Kiely, A. B.↗
NASA NTRS1995

Trellis complexity bounds for decoding linear block codes

We consider the problem of finding a trellis for a linear block code that minimizes one or more measures of trellis complexity. The domain of optimization may be different permutations of the same code or different codes with the same parameters. Constraints on trellises, including relationships between the minimal trellis of a code and that of the dual code, are used to derive bounds on complexity. We define a partial ordering on trellises: If a trellis is optimum with respect to this partial ordering, if has the desirable property that it simultaneously minimizes all of the complexity measures examined. We examine properties of such optimal trellises and give examples of optimal permutations of codes, most notably the (48,24,12) quadratic residue code.

Kiely, A. B.↗
NASA NTRS1995

Trellis Decoding Complexity of Linear Block Codes

We consider the problem of finding a trellis for a linear block code that minimizes one or more measures of trellis complexity. The domain of optimization may be different permutations of the same code, or different codes with the same parameters. Constraints on trellises, including relationships between the minimal trellis of a code and that of the dual code, are used to derive bounds on complexity. We define a partial ordering on trellises: if a trellis is optimum with respect to this partial ordering, it has the desirable property that it simultaneously minimizes all of the complexity measures examined. We examine properties of such optimal trellises and give examples of optimal permutations of codes, most notably the (48,24,12) quadratic residue code.

trellis decoding↗
NASA NTRS1994

Effects of Tangential Edge Constraints on the Postbuckling Behavior of Flat and Curved Panels Subjected to Thermal and Mechanical Loads

A parametric study of the effects of tangential edge constraints on the postbuckling response of flat and shallow curved panels subjected to thermal and mechanical loads is presented. The mechanical loads investigated are uniform compressive edge loads and transverse lateral pressure. The temperature fields considered are associated with spatially nonuniform heating over the panels, and a linear through-the-thickness temperature gradient. The structural model is based on a higher-order transverse-shear-deformation theory of shallow shells that incorporates the effects of geometric nonlinearities, initial geometric imperfections, and tangential edge motion constraints. Results are presented for three-layer sandwich panels made from transversely isotropic materials. Simply supported panels are considered in which the tangential motion of the unloaded edges is either unrestrained, partially restrained, or fully restrained. These results focus on the effects of the tangential edge restraint on the postbuckling response. The results of this study indicate that tangentially restraining the edges of a curved panel can make the panel insensitive to initial geometric imperfections in some cases.

Lin, W.↗
NASA NTRS1974

Detection of moisture and moisture related phenomena from Skylab

The author had identified the following significant results. Soil moisture and precipitation variations were not detectable as tonal variations on the S19OA IR B and W photography. Some light tonal areas contained high precipitation .83 inches and high moisture content 21.1% while other light tonal areas contained only .02 inches precipitation and as little as 0.7% moisture. Similar variations were observed in dark tonal areas. This inconsistency may be caused by a lapse of 3 to 4 days from the time precipitation occurred until the photographs were taken and the fact that in the first inch of soil the measured soil moisture was generally less than 5.0%. For overall tonal contrast, the aerial color, color IR and aerial B and W appear to be the best. Cities stand out from the landscape best in the aerial color and color IR, however, to see major street patterns a combination of the two aerial B and W bands and the two IR B and W bands may be desirable. For mapping roads it is best use all 6 bands. For lake detection, the IR B and W bands would be the best but for streams the aerial B and W band would be better. The aerial color, color IR, and the two IR B and W bands are best for distinguishing cultivated and non-cultivated areas, whereas the two aerial B and W bands are better for seeing local relief. Clouds may be best seen in the aerial color and color IR bands.

Eagleman, J. R.↗
NASA NTRS1974

Detection of moisture and moisture related phenomena from Skylab

The author has identified the following significant results. Data from five Skylab passes were combined to give a composite relationship between the S194 antennae temperature and soil moisture content in the surface to one inch layer. The five data sets were comparable and resulted in a correlation coefficient of -0.97. The regression equation was used to predict soil moisture content across the United States for one particular pass on August 5, 1973.

Eagleman, J. R.↗
NASA NTRS1974

Detection of moisture and moisture related phenomena from Skylab

The author has identified the following significant results. Skylab 2 data for June 5, 1973 (Texas site) relates favorably with previously calculated aircraft data when correlating brightness temperature to soil moisture. However, more detailed work is needed to determine the corrected surface temperature. In addition, correlations between the S194 antenna temperature and soil moisture have been obtained for five sets of Skylab data. The best correlations were obtained for the surface to one inch depth in four cases and for surface to two inches depth for the fifth case. Correlation coefficients for the surface to one inch depth were -0.98, -0.95, -0.90, -0.82, and -0.80.

Eagleman, J. R.↗
NASA NTRS1973

Detection of moisture and moisture related phenomena from Skylab

The author has identified the following significant results. Correlations between the S-194 antenna temperature and soil moisture have been obtained for three sets of data; one for Skylab 2 and two for Skylab 3. The best correlations were obtained for the surface to one inch depth in two cases and for the surface to two inches for the third case. Correlation coefficients for the surface to one inch depth were -0.98, -0.95, and -0.82. The lowest correlation coefficient was obtained with total soil moisture variations less than 4% across the test site.

Eagleman, J. R.↗