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Liu, Da

Publications and source records attributed to Liu, Da.

16 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

The constructive method for massive particles in QED

The constructive method of determining amplitudes from on-shell pole structure has been shown to be promising for calculating amplitudes in a more efficient way. However, challenges have been encountered when a massless internal photon is involved in the gluing of three-point amplitudes with massive external particles. In this paper, we use the original on-shell method, old-fashioned perturbation theory, to shed light on the constructive method, and show that one can derive the Feynman amplitude by correctly identifying the residue even when there is an internal photon involved.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2024

Composite resonances at a 10 TeV muon collider

We investigate the reach for resonances of the composite Higgs models at a 10 TeV μ + μ – collider with up to 10 ab –1 luminosity. The strong dynamics sector is modeled by the minimal coset SO(5)/SO(4), where vector resonances are in (3, 1) of SO(4) and fermions are in (2, 2). Various production and decay channels are studied. For the spin-1 resonances, the projections are made based on the radiative return and vector boson fusion production channels. The muon collider can cover most of the kinematically allowed mass range and can measure the coupling gρ to percent level. For the fermionic resonances (i.e. the top partners), pair production easily covers the resonance mass below 5 TeV, while single production extends the reach to 6 TeV for a small ξ = 0.015.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Primary observables for indirect searches at colliders

We consider the complete set of observables for collider searches for indirect effects of new heavy physics. They consist of SU(3) C × U(1) EM invariant interaction terms/operators that parameterize deviations from the Standard Model. We show that, un der very general assumptions, the leading deviations from the Standard Model are given by a finite number of ‘primary’ operators, with the remaining operators given by ‘Mandelstam descendants’ whose effects are suppressed by powers of Mandelstam variables divided by the mass scale M of the heavy physics. We explicitly determine all 3 and 4-point primary operators relevant for Higgs signals at colliders by using the correspondence between on-shell amplitudes and independent operators. We give a detailed discussion of the methods used to obtain this result, including a new analytical method for determining the independent operators. The results are checked using the Hilbert series that counts independent operators. We also give a rough sketch of the phenomenology, including unitarity bounds on the interaction strengths and rough estimates of their importance for Higgs decays at the HL-LHC. These results motivate further exploration of Higgs decays to $Z\overline{f}f$, $W\overline{f}f'$, $γ\overline{f}f$, and $Zγγ$.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2019

Broad composite resonances and their signals at the LHC

The existence of the SU (2) L triplet composite spin-1 resonances ρ ±,0 is a universal prediction of the strongly interacting new physics addressing the naturalness problem. Such resonances have not been found in the diboson final states, which are expected to be the dominant decay channels. In this work we propose a new scenario where the left-handed quark doublet qL = (t L , b L ) is fully composite. In this case, the ρ resonances can be broad and mainly decay to the third-generation quarks. The $t\bar{t}$ resonance search channel is comparable in sensitivity to the dilepton channel. In addition, the same-sign dilepton channel in $t\bar{t}$ ρ 0 -associated production can probe the large-width region and complement the Drell-Yan production channels.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2019

Universal relations in composite Higgs models

We initiate a phenomenological study of “universal relations” in composite Higgs models, which are dictated by nonlinear shift symmetries acting on the 125 GeV Higgs boson. These are relations among one Higgs couplings with two electroweak gauge bosons (HVV), two Higgses couplings with two electroweak gauge bosons (HHVV), one Higgs couplings with three electroweak gauge bosons (HVVV), as well as triple gauge boson couplings (TGC), which are all controlled by a single input parameter: the decay constant f of the pseudo-Nambu-Goldstone Higgs boson. Assuming custodial invariance in strong sector, the relation is independent of the symmetry breaking pattern in the UV, for an arbitrary symmetric coset G/H . The complete list of corrections to HVV, HHVV, HVVV and TGC couplings in composite Higgs models is presented to all orders in 1/ f , and up to four-derivative level, without referring to a particular G/H . We then present several examples of universal relations in ratios of coefficients which could be extracted experimentally. Measuring the universal relation requires a precision sensitive to effects of dimension-8 operators in the effective Lagrangian and highlights the importance of verifying the tensor structure of HHVV interactions in the standard model, which remains untested to date.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2019

Prospects of searching for composite resonances at the LHC and beyond

Composite Higgs models predict the existence of resonances. We study in detail the collider phenomenology of both the vector and fermionic resonances, including the possibility of both of them being light and within the reach of the LHC. We present current constraints from di-boson, di-lepton resonance searches and top partner pair searches on a set of simplified benchmark models based on the minimal coset SO(5)/SO(4), and make projections for the reach of the HL-LHC. We find that the cascade decay channels for the vector resonances into top partners, or vice versa, can play an important role in the phenomenology of the models. We present a conservative estimate for their reach by using the same-sign di-lepton final states. As a simple extrapolation of our work, we also present the projected reach at the 27 TeV HE-LHC and a 100 TeV pp collider.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2018

MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression

T helper 17 (Th17) cells has proven to be crucial in the pathogenesis of severe asthma. Although it is known that Suppressor of cytokine signaling 3 (SOCS3) is involved in differentiation of Th17 cells but, how it affects severe asthma is uncertain. Since previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) null mice was deficient in Th17 cell differentiation, the aim of the present study was to understand how MBD2 interacts with SOCS3 to regulate Th17 cell differentiation in severe asthma. Here, we show that SOCS3 expression was significantly decreased in Th17-mediated severe asthmatic mice, accompanied by elevated STAT3 phosphorylation and RORγt expression. Knock-down of SOCS3 promoted the differentiation of naïve T cells into Th17 cells through STAT3/RORγt pathway. Meanwhile, MBD2 was overexpressed in Th17-mediated severe asthmatic mice. Intervention of MBD2 expression lead to a negative change of SOCS3 expression, whereas the differentiation of Th17 cells showed positive change. In addition, MBD2 knockout (MBD2-KO) mice displayed increased SOCS3 expression and decreased Th17 differentiation after severe asthma modeling. Taken together, our results suggest that MBD2 might facilitate Th17 cell differentiation via down-regulating SOCS3 expression in severe asthma. These findings uncover new roles for SOCS3 and MBD2, and provide a potential target for treatment of severe asthma.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

A light Higgs at the LHC and the B-anomalies

After the Higgs discovery, the LHC has been looking for new resonances, decaying into pairs of Standard Model (SM) particles. Recently, the CMS experimen observed an excess in the di-photon channel, with a di-photon invariant mass of about 96 GeV. This mass range is similar to the one of an excess observed in the search for the associated production of Higgs bosons with the Z neutral gauge boson at LEP, with the Higgs bosons decaying to bottom quark pairs. On the other hand, the LHCb experiment observed a discrepancy with respect to the SM expectations of the ratio of the decay of B -mesons to K -mesons and a pair of leptons, \( {R}_{K^{\left(\ast \right)}}=BR\left(B\to {K}^{\left(\ast \right)}{\mu}^{+}{\mu}^{-}\right)/BR\left(B\to {K}^{\left(\ast \right)}{e}^{+}{e}^{-}\right) \) . This observation provides a hint of the violation of lepton-flavor universality in the charged lepton sector and may be explained by the existence of a vector boson originating form a \( U{(1)_{L_{\mu}}}_{-{L}_{{}_{\tau }}} \) symmetry and heavy quarks that mix with the left-handed down quarks. Since the coupling to heavy quarks could lead to sizable Higgs di-photon rates in the gluon fusion channel, in this article we propose a common origin of these anomalies identifying a Higgs associated with the breakdown of the \( U{(1)_{L_{\mu}}}_{-{L}_{{}_{\tau }}} \) symmetry and at the same time responsible to the quark mixing, with the one observed at the LHC. We also discuss the constraints on the identification of the same Higgs with the one associated with the bottom quark pair excess observed at LEP.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2016

MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ–dependent manner

MicroRNAs (miRNAs) play significant roles in multiple diseases by regulating the expression of their target genes. Type 2 diabetes mellitus (T2DM) is a chronic endocrine and metabolic disease with complex mechanisms. T2DM can result in diabetic osteoporosis (DO), which is characterized by bone loss, decreased bone mineral density and increased bone fractures. The promotion of osteogenic differentiation of osteoblasts is an effective way to treat osteoporosis. In the present study, high glucose (HG) and free fatty acids (FFA) were employed to mimic T2DM in MC3T3-E1 cells. To induce osteogenic differentiation, MC3T3-E1 cells were cultured in osteogenic medium. The results showed that osteogenic differentiation was significantly suppressed by HG and FFA. We found that miR-132 expression was significantly upregulated and much higher in HG-FFA–induced cells than other selected miRNAs, indicating that miR-132 might play an important role in DO. Furthermore, overexpression of miR-132 markedly inhibited the expression of key markers of osteogenic differentiation and alkaline phosphatase (ALP) activity. Reciprocally, inhibition of miR-132 restored osteogenic differentiation, even under treatment with HG-FFA. We also showed that Sirtuin 1 (Sirt1) was one of the target genes of miR-132, whose expression was controlled by miR-132. Ectopic expression of Sirt1 reversed the decrease in osteogenic differentiation caused by miR-132 and HG-FFA. These results demonstrated the direct role of miR-132 in suppressing osteogenic differentiation through downregulating Sirt1. Moreover, we demonstrated that peroxisome proliferator-activated receptor β/δ (PPARβ/δ) was a downstream molecule of Sirt1, and its knockout by PPARβ/δ siRNA significantly abolished the promotive effects of Sirt1 on osteogenic differentiation, indicating that Sirt1 functioned in a PPARβ/δ–dependent manner. Taken together, we provide crucial evidence that miR-132 plays a key role in regulating osteogenic differentiation through Sirt1 in a PPARβ/δ–dependent manner, indicating that miR-132 and Sirt1-PPARβ/δ may act as potential therapeutic targets for T2DM–induced osteoporosis. - Highlights: • MiR-132 participates in regulating osteogenic differentiation of MC3T3-E1 cells. • Sirt1 is a target gene of miR-132. • Sirt1 is the effector of miR-132 in regulating osteogenic differentiation. • MiR-132-Sirt1 regulates osteogenic differentiation in a PPARβ/δ–dependent manner.

60 APPLIED LIFE SCIENCES↗