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Liu, Juewen

Publications and source records attributed to Liu, Juewen.

4 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2015

Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2013

Nucleic acid based fluorescent sensor for mercury detection

A nucleic acid enzyme comprises an oligonucleotide containing thymine bases. The nucleic acid enzyme is dependent on both Hg.sup.2+and a second ion as cofactors, to produce a product from a substrate. The substrate comprises a ribonucleotide, a deoxyribonucleotide, or both.

59 BASIC BIOLOGICAL SCIENCES↗