Engineering topics

Lytle, Andrew

Publications and source records attributed to Lytle, Andrew.

5 records

DOE OSTI2024

B-meson semileptonic decays from highly improved staggered quarks

We present an update for results on B-meson semileptonic decays using the highly improved staggered quark (HISQ) action for both valence and 2+1+1 sea quarks. The use of the highly improvedaction, combined with the MILC collaboration’s gauge ensembles with lattice spacings down to $\sim$0.03fm, allows the $b$ quark to be treated with the same discretization as the lighter quarks. The talk willfocus on updated results for $B_{(s)} \to D_{(s)}$, $B_{(s)} \to K$ scalar and vector form factors.

Lytle, Andrew↗

DOE OSTI2024

Form factors for semileptonic B-decays with HISQ light quarks and clover b-quarks in Fermilab interpretation

We compute the vector, scalar, and tensor form factors for the $B\to \pi$, $B\to K$, and $B_s\to K$ amplitudes, which are needed to describe semileptonic $B$-meson decay rates for both the charged and neutral current cases. We use the highly improved staggered quark (HISQ) action for the sea and light valence quarks. The bottom quark is described by the clover action in the Fermilab interpretation. Simulations are carried out on $N_f = 2+1+1$ MILC HISQ ensembles at approximate lattice spacings from $0.15$ fm down to $0.057$ fm. We present blinded preliminary results for the form factors.

Jeong, Hwancheol↗

DOE OSTI2023

$B$-meson semileptonic decays with highly improved staggered quarks

We present an update of the Fermilab Lattice and MILC Collaborations project to compute the form factors for semileptonic $B_{(s)}$-meson decays. Our calculation uses the highly improved staggered quark (HISQ) action for sea and valence quarks, and ensembles with up, down, strange, and charm quarks in the sea. Using a highly improved action with the MILC Collaboration's gauge ensembles with lattice spacings down to $a\approx0.03$ fm, allows the heavy valence quarks to be treated with the same discretization as the light and strange quarks. This unified treatment of the valence quarks allows for absolutely normalized vector currents, bypassing the need for perturbative matching, which has been a source of uncertainty in previous calculations of $B$-meson decay form factors by our collaboration. All preliminary form-factor results are blinded.

Lytle, Andrew↗

DOE OSTI2022

BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization of BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show that BCL10 mutants fall into at least two functionally distinct classes: missense mutations of the BCL10 CARD domain and truncation of its C-terminal tail. Truncating mutations abrogated a motif through which MALT1 inhibits BCL10 polymerization, trapping MALT1 in its activated filament-bound state. CARD missense mutations enhanced BCL10 filament formation, forming glutamine network structures that stabilize BCL10 filaments. Mutant forms of BCL10 were less dependent on upstream CARD11 activation and thus manifested resistance to BTK inhibitors, whereas BCL10 truncating but not CARD mutants were hypersensitive to MALT1 inhibitors. Therefore, BCL10 mutations are potential biomarkers for BTK inhibitor resistance in ABC-DLBCL, and further precision can be achieved by selecting therapy based on specific biochemical effects of distinct mutation classes.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2021

B- and D-meson semileptonic decays with highly improved staggered quarks

We present results for $B_{(s)}$- and $D_{(s)}$-meson semileptonic decays from ongoing calculations by the Fermilab Lattice and MILC Collaborations. Our calculation employs the highly improved staggered quark (HISQ) action for both sea and valence quarks and includes several ensembles with physical-mass up, down, strange, and charm quarks and lattice spacings ranging from $a\approx0.15$ fm down to 0.06 fm. At most lattice spacings, an ensemble with physical-mass light quarks is included. The use of the highly improved action, combined with the MILC Collaboration's gauge ensembles with lattice spacings down to $a\approx0.042$ fm, allows heavy valence quarks to be treated with the same discretization as the light and strange quarks. This unified treatment of the valence quarks allows (in some cases) for absolutely normalized currents, bypassing the need for perturbative matching, which has been a leading source of uncertainty in previous calculations of $B$-meson decay form factors by our collaboration. All preliminary form-factor results are blinded.

Jay, William I.↗