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Mansfield, J. M.

Publications and source records attributed to Mansfield, J. M..

13 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1985

Role of interferon in resistance and immunity to protozoa

Production of interferon (I) in response to protozoan infection, and the interferon-mediated inhibition of parasite replication were studied in order to determine if these effects may be related to immunologic-mediated resistance of the hosts. Two extracellular parasites-Trypanosoma brucei rhodesiense and Naegleria fowlei were used. Upon infection with the trypanosome, only resistant strains of mice produced I. An early peak of alpha/beta I is followed by appearance of gamma I, which coincided with antibody production and a drop in parasitemia. In case of the amoeba, pretreatment of its suspension with alpha/beta I inhibits its replication in vitro, and appears to protect mice from the infection and the disease. It is proposed that production of interferon, with its regulatory effect on the immune responses, may play a major role in regulating the processes of protozoan-caused diseases.

Sonnenfeld, G.↗
NASA NTRS1985

Interferon effects on protozoan infections

The effects of interferon (IFN) on mice infected with two different parasitic protozoans, Trypanosoma cruzi and Trypanosoma brucei rhodesiense, are investigated experimentally. The preparation of the cell cultures, IFN and assays, antibody, and the experimental procedures are described. It is observed that in cells treated with IFN-gamma there is an increased association of T. cruzi with murine macrophages and an increase in the killing of T. cruzi by IFN-gamma-treated murine macrophages. For spleen cells infected with T.b. rhodesiense in vitro, it is detected that live trypanosomes cannot induce IFN in cells from normal mice, but can in cells from immunized mice; and that trypanosome-lysates induce IFN in vitro in cells from normal mice. The data suggest that there is a two-step mechanism for mice against T. cruzi and T.b. rhodesiense.

Sonnenfeld, G.↗
NASA NTRS1976

LANDSAT/MMS propulsion module design. Volume 1: Task 4.3, trade studies

Evaluations are presented of alternative LANDSAT follow-on launch configurations to derive the propulsion requirements for the multimission modular spacecraft (MMS). Two basic types were analyzed including use of conventional launch vehicles and shuttle-supported missions. It was concluded that two sizes of modular hydrazine propulsion modules would provide the most cost-effective combination for future missions of this spacecraft. Conceptual designs of the selected propulsion modules were performed to the depth permitting determination of mass properties and estimated costs.

Mansfield, J. M.↗
NASA NTRS1976

LANDSAT/MMS propulsion module design. Tas4.4: Concept design

Evaluations are presented of alternative LANDSAT follow-on launch configurations to derive the propulsion requirements for the multimission modular spacecraft (MMS). Two basic types were analyzed including use of conventional launch vehicles and shuttle supported missions. It was concluded that two sizes of modular hydrazine propulsion modules would provide the most cost-effective combination for future missions of this spacecraft. Conceptual designs of the selected propulsion modules were performed to the depth permitting determination of mass properties and estimated costs.

Mansfield, J. M.↗
NASA NTRS1975

Remote servicing of free-flying spacecraft

A ground simulation to demonstrate system compatibility by enacting satellite ground installation, orbit delivery, space servicing, and contingency retrieval with the space shuttle orbiter was conducted. The basic configuration approach adopted for the spacecraft groups the standardized subsystems in the aft portion of the spacecraft and leaves the volume forward of the transition structure available for the mission peculiar equipment and sensors. The version used for this simulation is configured as an earth observatory with multispectral mapping and high resolution imaging sensors. All modules including the propulsion package and the sensor modules are replaceable on orbit in the event of depletion, wearout, malfunction, or the availability of an improved version.

Cepollina, F. J.↗
NASA NTRS1972

Shuttle/typical payload interface study

Concept synthesis and preliminary design studies are summarized of support systems to implement the launch/refurbishment/retrieval with shuttle of a family of low cost earth observation satellites in low earth orbit. Shuttle constraints and issues are described.

Mansfield, J. M.↗