Scintillator screen development for proton radiography
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LYSO scintillator screen proton radiography↗
Engineering topics
Mariam, Fesseha Gebre
Publications and source records attributed to Mariam, Fesseha Gebre.
Scintillator screen development for proton radiography
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Morris, Christopher↗
Gold leaf phantom development for the assessment of proton radiographic sensitivity limits simulating gold nanoparticle tagged tumors
Proton radiography may guide proton therapy cancer treatments with beam’s-eye-view anatomical images and a proton-based estimation of proton stopping power. However, without contrast enhancement, proton radiography will not be able to distinguish tumor from tissue. To provide this contrast, functionalized, high-Z nanoparticles that specifically target a tumor could be injected into a patient before imaging. We conducted this study to understand the ability of gold, as a high-Z, biologically compatible tracer, to differentiate tumors from surrounding tissue. We indicate that AuNP-enhanced proton radiography might be a feasible technology to provide image-guidance to proton therapy, potentially reducing off-target effects and sparing nearby tissue. These data can be used to develop treatment plans and clinical applications can be derived from the simulations.
62 RADIOLOGY AND NUCLEAR MEDICINE↗