Engineering topics

Martin, K.

Publications and source records attributed to Martin, K..

4 records

DOE OSTI2020

Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS) Final Report

The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals, our specific aims are to:1.) Increase the value and information content of AMS measurements by combining molecular speciation with quantitation of defined macromolecular isolates. Specifically, develop and validate methods for macromolecule labeling, characterization and quantitation.2.) Develop and validate methods and strategies to enable AMS to become more broadly used in human studies. Specifically, demonstrate robust methods for conducting pharmacokinetic/pharmacodynamics studies in humans and model systems.3.) Increase the accessibility of AMS to the Biomedical research community and the throughput of AMS through direct coupling to separatory instruments.4.) Provide high throughput 14C BioAMS analysis for collaborative and service clients.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

NASA NTRS1994

Multi-wavelength study of NGC 281 A

We present a study of the molecular cloud NGC 281 A and the associated compact and young star cluster NGC 281 (AS 179). Optical photometry leads to a new distance of 3500 pc for the star cluster which is in good agreement with the kinematical distance of the adjacent molecular cloud NGC 281 A. The exciting star HD 5005 of the optical nebulosity is a Trapezium system with O6 III as photometric spectral type for the component HD 5005 AB. For the age of the star cluster we estimated a value of about 3 x 10(exp 6) yr. The (12)CO (2 to 1), (13)CO (2 to 1), and (12)CO (3 to 2) emission shows that the molecular cloud NGC 281 A consists of two cloud fragments. The western fragment is more compact and massive than the eastern fragment and contains an NH3 core. This core is associated with the IRAS source 00494+5617, an H2O maser, and 1.3 millimeter dust continuum radiation. Both cloud fragments contain altogether 22 IRAS point sources which mostly share the properties of young stellar objects. They have luminosities between 150 and 8800 solar luminosity. The maxima of the 60 and 100 micrometers HIRES maps correspond to the maxima of the (12)CO (3 to 2) emission. The NGC 281 A region shares many properties with the Orion Trapezium-BN/KL region the main differences being a larger separation between the cluster centroid and the new site of star formation as well as a lower mass and luminosity of the molecular cloud and the infrared cluster.

Henning, TH.↗

NASA NTRS1982

Oxidative peptide /and amide/ formation from Schiff base complexes

One hypothesis of the origin of pre-modern forms of life is that the original replicating molecules were specific polypeptides which acted as templates for the assembly of poly-Schiff bases complementary to the template, and that these polymers were then oxidized to peptide linkages, probably by photo-produced oxidants. A double cycle of such anti-parallel complementary replication would yield the original peptide polymer. If this model were valid, the Schiff base between an N-acyl alpha mino aldehyde and an amino acid should yield a dipeptide in aqueous solution in the presence of an appropriate oxidant. In the present study it is shown that the substituted dipeptide, N-acetyl-tyrosyl-tyrosine, is produced in high yield in aqueous solution at pH 9 through the action of H2O2 on the Schiff-base complex between N-acetyl-tyrosinal and tyrosine and that a great variety of N-acyl amino acids are formed from amino acids and aliphatic aldehydes under similar conditions.

Strehler, B. L.↗

NASA NTRS1973

Facilitating the exploitation of ERTS imagery using snow enhancement techniques

The author has identified the following significant results. Comparative analysis of snow-free and snow-covered imagery of the New England Test Area has resulted in a larger number of lineaments mapped from snow-covered imagery in three out of four sets of comparative imagery. Analysts unfamiliar with the New England Test Area were utilized; the quality of imagery was independently judged to be uniform. In all image sets, a greater total length of lineaments was mapped with the snow-covered imagery. The value of this technique for fracture mapping in areas with thick soil cover is suggested. A number of potentially useful environmental applications of snow enhancement related to such areas as mining, land use, and hydrology have been identified.

Wobber, F. J.↗