Engineering topics
Matsumoto, Toshio
Publications and source records attributed to Matsumoto, Toshio.
Update of the Bisphosphonate ISS Flight Experiment
The bisphosphonate study is an international collaboration between the NASA and JAXA space agencies to investigate the potential value of antiresorptive drugs to mitigate the well-established bone changes associated with long-duration spaceflight. Our hypothesis is that an antiresorptive drug in combination with in-flight exercise will ameliorate bone loss and hypercalcuria during long-duration spaceflight. We have completed data analysis for 7 crewmembers treated with alendronate during flight and 3 of 10 controls without treatment. We previously reported the pre/postflight changes in bone density and the pre versus in-flight changes in various biomarkers in crewmembers taking alendronate during flight. The purpose of this report is to compare these results with the 12- month follow-up data. The table below presents these data as a percentage change from baseline either immediately postflight or in-flight (biochemical markers) with a 1-year follow-up.
Bisphosphonate ISS Flight Experiment
The bisphosphonate study is a collaborative effort between the NASA and JAXA space agencies to investigate the potential for antiresorptive drugs to mitigate bone changes associated with long-duration spaceflight. Elevated bone resorption is a hallmark of human spaceflight and bed rest (common zero-G analog). We tested whether an antiresorptive drug in combination with in-flight exercise would ameliorate bone loss and hypercalcuria during longduration spaceflight. Measurements include DXA, QCT, pQCT, and urine and blood biomarkers. We have completed analysis of 7 crewmembers treated with alendronate during flight and the immediate postflight (R+<2 week) data collection in 5 of 10 controls without treatment. Both groups used the advanced resistive exercise device (ARED) during their missions. We previously reported the pre/postflight results of crew taking alendronate during flight (Osteoporosis Int. 24:2105-2114, 2013). The purpose of this report is to present the 12-month follow-up data in the treated astronauts and to compare these results with preliminary data from untreated crewmembers exercising with ARED (ARED control) or without ARED (Pre-ARED control). Results: the table presents DXA and QCT BMD expressed as percentage change from preflight in the control astronauts (18 Pre-ARED and the current 5 ARED-1-year data not yet available) and the 7 treated subjects. As shown previously the combination of exercise plus antiresorptive is effective in preventing bone loss during flight. Bone measures for treated subjects, 1 year after return from space remain at or near baseline values. Except in one region, the treated group maintained or gained bone 1 year after flight. Biomarker data are not currently available for either control group and therefore not presented. However, data from other studies with or without ARED show elevated bone resorption and urinary Ca excretion while bisphosphonate treated subjects show decreases during flight. Comparing the two control groups suggests significant but incomplete improvement in maintaining BMD using the newer exercise protocols compared to earlier resistive exercise protocols. Quantitative characterization of this improvement requires additional measurements in the ARED control group that we are currently collecting. In conclusion, these results indicate that an antiresorptive may be an effective adjunct to exercise during long-duration spaceflight.
Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss
Experiment Hypothesis -- The combined effect of anti-resorptive drugs plus in-flight exercise regimen will have a measurable effect in preventing space flight induced bone mass and strength loss and reducing renal stone risk.
Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss
Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss (Bisphosphonates) will determine whether antiresorptive agents, in conjunction with the routine inflight exercise program, will protect ISS crewmembers from the regional decreases in bone mineral density documented on previous ISS missions.
A Search for a Near-Infrared Halo Around NGC 4565
We present a near-infrared (3.5-5 micron) search for the integrated emission from low-mass stars and/or brown dwarfs in the halo of the nearby edge-on spiral galaxy NGC 4565. The observation was made with a liquid-helium-cooled rocket-borne telescope using a 256 x 256 InSb array with a pixel scale of 17". Images of NGC 4565 were successfully obtained with sensitivity near the natural background limit. Our search reveals no evidence of a faint halo around the galaxy, in contrast with the previous reports of a halo around NGC 5907. The lower limit of the mass-to-light ratio for the halo of NGC 4565 is 260 (2 delta) in solar units at 3.5-5 microns. This implies that hydrogen-burning stars do not contribute significantly to the mass of the dark halo in NGC 4565.
A new network of faint calibration stars from the near infrared spectrometer (NIRS) on the IRTS
The point source extraction and calibration of the near infrared spectrometer (NIRS) onboard the Infrared Telescope in Space (IRTS) is described. About 7 percent of the sky was observed during a one month mission in the range of 1.4 micrometers to 4 micrometers. The accuracy of the spectral shape and absolute values of calibration stars provided by the NIRS/IRTS were validated.
Rocket-borne instrument for observations of near-infrared and far-infrared extended astrophysical emission
We give a detailed description of the design and flight performance of an instrument onboard the S-520-15 rocket of the Institute of Space and Astronautical Science. The isntrument, consisting of a near-infrared spectrometer and a far-infrared photometer at the focus of a 10 cm liquid-helium cooled telescope, was designed to observe both the brightness and distribution of diffuse emission with high sensitivity. The rocket was successfully launched and the instrument observed near-infrared and far-infrared continuum emission, as well as (C II) 157.7 micrometer line emission from regions at high Galactic latitude. We also give a brief description of the design and performance of an onboard attitude control system.
Cosmological implication of a new measurement of the submillimeter background radiation
A new submillimeter measurement of the cosmic background radiation (T. Matsumoto et al., 1988) reveals excess brightness between 1000 and 300 microns. The excess corresponds to about 10 percent of the undistorted blackbody radiation. The observed excess is consistent with thermal emission from dust with a relative density of 0.0001-0.00001, if the dust is heated at a redshift z of about 10-40.