A Widespread Low-Latitude Diurnal CO2 Frost Cycle Revealed by Mars Climate Sounder
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Engineering topics
Publications and source records attributed to McCleese, D..
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Metabolic bone diseases like osteoporosis result from the disruption of normal bone mineral balance (BMB) resulting in bone loss. During spaceflight astronauts lose substantial bone. Bed rest provides an analog to simulate some of the effects of spaceflight; including bone and calcium loss and provides the opportunity to evaluate new methods to monitor BMB in healthy individuals undergoing environmentally induced-bone loss. Previous research showed that natural variations in the Ca isotope ratio occur because bone formation depletes soft tissue of light Ca isotopes while bone resorption releases that isotopically light Ca back into soft tissue (Skulan et al, 2007). Using a bed rest model, we demonstrate that the Ca isotope ratio of urine shifts in a direction consistent with bone loss after just 7 days of bed rest, long before detectable changes in bone mineral density (BMD) occur. The Ca isotope variations tracks changes observed in urinary N-teleopeptide, a bone resorption biomarker. Bone specific alkaline phosphatase, a bone formation biomarker, is unchanged. The established relationship between Ca isotopes and BMB can be used to quantitatively translate the changes in the Ca isotope ratio to changes in BMD using a simple mathematical model. This model predicts that subjects lost 0.25 +/- 0.07% (+/- SD) of their bone mass from day 7 to day 30 of bed rest. Given the rapid signal observed using Ca isotope measurements and the potential to quantitatively assess bone loss; this technique is well suited to study the short-term dynamics of bone metabolism.
This document describes the planning processes used to achieve, and the outcome of, the sytrhesis that culminate in a strategy for the intensified scientific exploration of Mars in the time period from 2009-2020.
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The overall spin or "superrotation" of the Venus atmosphere is a striking phenomenon. In the 15 years since the NASA Pioneer Venus mission, a first-order understanding has been reached of the dynamics of the atmospheric region near and just above the Venus cloud tops. Tidal motions induced by solar heating produce a traveling disturbance whose vertical momentum transports are balanced by mean flow advection. The balance explains the strength of the mean flow above the clouds, and partially explains the strength of the mean flow at the cloud level where the strongest superrotation of the atmosphere occurs. But the fundamental cause of the global superrotation remains a mystery in spite of data from Earth-based observatories, from Pioneer Venus, from several Russian probes, from a Russian/French balloon experiment, and from the NASA Galileo flyby. The key missing knowledge is of momentum transfer processing the deep atmosphere, between the surface and the cloud deck. Neither the forcing nor the drag and dissipation mechanisms are known. The existing data are reviewed here and theoretical suggestions are listed. It is concluded that further measurements, in conjunction with numerical modeling, will be required to resolve this puzzling and challenging question. New data must improve by an order of magnitude on the accuracies achieved by the Pioneer Venus probes. Velocities in the deep atmosphere must be measured to better than 0.1 m/s and relative temperatures to beter than 0.1 K near the surface.