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McGuire, Steve

Publications and source records attributed to McGuire, Steve.

Initial Incidence of White Matter Hyperintensities on MRI in Astronauts

Introduction: Previous literature has described the increase in white matter hyperintensity (WMH) burden associated with hypobaric exposure in the U-2 and altitude chamber operating personnel. Although astronauts have similar hypobaric exposure pressures to the U2 pilot population, astronauts have far fewer exposures and each exposure would be associated with a much lower level of decompression stress due to rigorous countermeasures to prevent decompression sickness. Therefore, we postulated that the WMH burden in the astronaut population would be less than in U2 pilots. Methods: Twenty-one post-flight de-identified astronaut MRIs (5 mm slice thickness FLAIR sequences) were evaluated for WMH count and volume. The only additional data provided was an age range of the astronauts (43-57) and if they had ever performed an EVA (13 yes, 8 no). Results: WMH count in these 21 astronaut MRI was 21.0 +/- 24.8 (mean+/- SD) and volume was 0.382 +/- 0.602 ml, which was significantly higher than previously published results for the U2 pilots. No significant differences between EVA and no EVA groups existed. Age range of astronaut population is not directly comparable to the U2 population. Discussion: With significantly less frequent (sometimes none) and less stressful hypobaric exposures, yet a much higher incidence of increased WMH, this indicates the possibility of additional mechanisms beyond hypobaric exposure. This increase unlikely to be attributable just to the differences in age between astronauts and U2 pilots. Forward work includes continuing review of post-flight MRI and evaluation of pre to post flight MRI changes if available. Data mining for potential WMH risk factors includes collection of age, sex, spaceflight experience, EVA hours, other hypobaric exposures, hyperoxic exposures, radiation, high performance aircraft experience and past medical history. Finally, neurocognitive and vision/eye results will be evaluated for any evidence of impairment linked to increased WMH.

Norcross, Jason

Exploration of Planetary Skylights and Tunnels

While planetary pits and caves have been fiction for a century, they have been seen from orbit only in the last few years. These discoveries exceed the fantasies in diversity, scale, and abundance. For pits and caves, this is the age of discovery, ranging from a few pits on the Moon and Mars in 2009 to hundreds within the time of this research, with many more to come. Pits with subsurface voids have been confirmed on the Moon and Mars and indicated on Venus, Phobos, Eros, Gaspra, Ida, Enceladus, and Europa. Compelling next steps are surface and subsurface exploration.Pits and caves are opportunistic study targets for unique origins, geology, and climate that will broadly impact planetary science. Holes on Mars are of particular interest because their interior caves are relatively protected from the harsh surface, making them good candidates to contain Martian life. Pits are prime targets for possible future spacecraft, robots, and even human interplanetary explorers. Caves and caverns could be ready-_made shelters for future Moon and Mars explorers and colonists. Discoveries to date look down from on high with satellites but cannot reveal the wonders of caves. They cannot enter, touch, or view pits up close. Genuine exploration is only achievable through surface missions. Robotic missions can assess suitability for safe entry and habitation, plus inform techniques for developing subsurface infrastructure.Missions into planetary voids redefine the future of exploration, science, and habitation beyond Earth. We can reach this future only by targeting specific technological advancement now. Prior missions and current roadmap priorities target regions of benign terrain. While in-cave concepts have been postulated, the critical technologies have not been identified and demonstrated.While robotic exploration of skylights and caves can seek out life, investigate geology and origins, and open the subsurface of other worlds to humankind, it is a daunting venture. Planetary voids present perilous terrain requiring innovative technologies for access, exploration, and modeling. These same technologies are broadly applicable to explorations of rough and/or subsurface planetary environments, including caves, craters, cliffs, and rock fields. This research speculates on the possibilities and means of such exploration with fundamental contributions to exploring, modeling, and visualizing this new class of large-scale, highly three-dimensional concave planetary features.

Whittaker, Red

A Framework for Distributed Rover Control and Three Sample Applications

In order to develop quality control software for multiple robots, a common interface is required. By developing components in a modular fashion with well-defined boundaries, roboticists can write code to program a generic rover, and only require very simple modifications to run on any robot with a properly implemented framework. The proposed framework advances a Generic Rover that could be any rover, from Real World Interface's All Terrain Robot Vehicle Jr. series to the Fido-class rovers from the Jet Propulsion Laboratory to any other research robot. Using these generic hardware interfaces, software designers and engineers can concentrate on the actual code, and not have to worry about hardware details. In addition to the hardware support framework, three sample applications have been developed to demonstrate the flexibility and extensibility of the framework.

McGuire, Steve