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Mccutcheon, E. P.

Publications and source records attributed to Mccutcheon, E. P..

12 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1982

Cardiovascular responses of the chronically instrumented monkey during simulated space flight

A pod enclosure system designed by the Environmental Physiology Laboratory at the University of California at Berkeley is found to be eminently suitable for work with monkeys. The pattern of cardiovascular activity is found to vary. In the first half of the exposure, the hourly mean values suggest an initial period of instability, most marked for heart rate, beginning at 'launch.' In the second half of the exposure, the final three days, the responses appear much more ordered, with a stable phase relationship between circadian shifts in heart rate and mean aortic pressure. Since the latter stability is more normal, the assumption is made that the animal had become adjusted to its situation. Imposition of a daily lower body negative pressure (LBNP) stress shows characteristic responses.

Mccutcheon, E. P.↗
NASA NTRS1980

Body acceleration distribution and O2 uptake in humans during running and jumping

The distribution of body acceleration and associated oxygen uptake and heart rate responses are investigated in treadmill running and trampoline jumping. Accelerations in the +Gz direction were measured at the lateral ankle, lumbosacral region and forehead of eight young men during level treadmill walking and running at four speeds and trampoline jumping at four heights, together with corresponding oxygen uptake and heart rate. With increasing treadmill speed, peak acceleration at the ankle is found always to exceed that at the back and forehead, and acceleration profiles with higher frequency components than those observed during jumping are observed. Acceleration levels are found to be more uniformly distributed with increasing height in jumping, although comparable oxygen uptake and heat rates are obtained. Results indicate that the magnitude of the biomechanical stimuli is greater in trampoline jumping than in running, which finding could be of use in the design of procedures to avert deconditioning in persons exposed to weightlessness.

Bhattacharya, A.↗
NASA NTRS1979

Continuous metabolic and cardiovascular measurements on a monkey subject during a simulated 6-day Spacelab mission

A 10-kg male pig-tailed monkey (Macaca nemestrina) was selected as an optimal species for spaceflight studies on weightlessness. Three days before the simulated launch, the animal was placed in a fiberglass pod system to provide continuous measurement of respiratory gas exchange. Attention is given to examining the effects of weightlessness on several basic parameters of metabolic and cardiovascular function in an adult nonhuman primate. The 10.7-day total simulated-experiment period consisted of preflight 2.6 days, inflight 6.3 days, and postflight 1.8 days. Statistically significant diurnal variation was noted in oxygen consumption and CO2 production rates, body temperature and HR, but not in respiratory quotient or blood pressure. The high quality of the continuous data obtained demonstrates the feasibility of performing sound physiological experimentation on nonhuman primates in the Spacelab environment.

Pace, N.↗
NASA NTRS1978

Continuous metabolic and cardiovascular measurements on a monkey subject during a simulated 6-day Spacelab mission

An adult male pig-tailed monkey (Macaca nemestrina) with surgically implanted biotelemetry unit was inserted into a fiberglass pod system which was installed in a Spacelab mock-up to simulate a 6-day mission during which extensive physiological measurements were obtained. The purpose of the pod was to make possible the study of respiratory gas exchange. Body temperature and selected cardiovascular parameters were recorded continuously for 2.6 days prior to 'launch', 6.3 days during 'flight', and 1.8 days after 'landing'. The results are surveyed, and it is concluded that it is feasible to perform sound physiological experiments on nonhuman primates in the Spacelab environment

Pace, N.↗
NASA NTRS1977

Multichannel implantable telemetry system

Multiplexed biotelemetry system for animal research combines several power-saving features. Implantable sensor measures up to eight parameters simultaneously, including blood flow. Microamp transistors, switching circuits, and CMOS technology are used to lower power requirements. However, when blood flow is monitored, these measures are insufficient to reduce power enough for long-term operation from implantable primary battery.

Fryer, T. B.↗
NASA NTRS1977

Metabolic and cardiovascular adaptation, monkey. NASA SMD 3, project 76, experiment 44 conducted at NASA/JSC, 14-25 May 1977

The biomedical results from an experiment on a monkey subjected to space flight conditions are reported. A background history of the development and testing of an experiment system designed to permit measurement of physiological parameters in subhuman primates during continuous, comfortable, couch restraint for periods of up to 30 days is reviewed. Of major importance in the experimental design of the system was the use of a fiberglass pod, which could be sealed and subdivided into upper and lower parts, to monitor and control the physiological responses for various parts of the animal's body. The experiment was conducted within the Spacelab Simulator for a period of 11 days. Data recorded includes: Spacelab Simulator cabin temperature; ventilation rate; pod internal temperature; fraction percent oxygen; fraction percent carbon dioxide; oxygen consumption rate; carbon dioxide production rate; respiratory quotient; intrathoracic temperature; heart rate; mean aortic pressure; mean ventricular pressure; diurnal variation of parameters measured; comparison of mean preflight, flight, and postflight values of the parameters measured; and correlation matrix for the parameters measured.

Pace, N.↗
NASA NTRS1977

Instrumentation for space flight experiments

The selection of measurement systems for experiments conducted in the context of a space flight must be guided by the criteria applicable to any scientific study requiring objective measurements of physiological variables. Steps fundamental to the process of choosing the best instrumentation system are identified and the key factors in matching the operational characteristics of the instrumentation to its intended use are discussed. Special problems in obtaining data from nonhuman primates, whether restrained or unrestrained, are explored. Choices for data processing are evaluated as well as the use of prototype flight tests and simulations to assess future life science experiments for spacelab or payloads for the space shuttle biomedical scientific satellite.

Mccutcheon, E. P.↗
NASA NTRS1976

An objective determination of /+/G-sub z acceleration tolerance

The paper describes a method for objective determination of (+)G-sub z (head-to-foot) acceleration tolerance. Using noninvasive instrumentation based on a transcutaneous Doppler flow system, objective end point criteria have been developed based on measured blood flow to the head. The system consists of miniature 8 MHz Doppler sensors placed on the forehead over both frontal branches of the temporal arteries to detect blood flow velocity from backscattered ultrasound. Over 100 subjects have been studied during more than 2000 centrifuge runs

Sandler, H.↗
NASA NTRS1975

A multichannel implantable telemetry system for flow, pressure, and ECG measurements

The design, principles of operation, and performance of an implantable miniaturized (48 cu cm in volume) multiplex telemetry system for simultaneous measurement of up to eight physiological parameters (including cardiovascular data) are described. Integrated circuits are used to reduce the size, complexity, and cost of fabrication. Power consumption is reduced using recently developed complementary MOS devices. PWM technique is selected as it is relatively easy to implement, lends itself to ICs, and provides an accurate means of transmitting data. The system is totally implantable within the chest of a test animal, with no wire penetrating through the skin. It is shown that the described system permits repeated measurement of the physiological effects of a variety of interventions in awake unanesthetized animals.

Fryer, T. B.↗
NASA NTRS1975

Recent NASA contributions to biomedical telemetry

The present work reviews technological progress over the past five years in the field of long-term telemetric monitoring of physiological parameters during space flight. Emphasis is placed on those developments that have direct application to animal or human use on earth. An effort was made in these recent developments to free subjects from encumbering wires: a swallowable telemetry capsule for monitoring body temperature and a wristwatch transmitter connected to EKG leads were two of the devices developed.

Sandler, H.↗