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Monson, C. B.

Publications and source records attributed to Monson, C. B..

7 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1988

Core temperature is regulated, although at a lower temperature, in rats exposed to hypergravic fields

1. In rats acclimated to 23 degrees C (RT rats) or 5 degrees C (CA rats), core temperature (Tc), tail temperature (Tt) and oxygen consumption (VO2) were measured during exposure to a hypergravic field. 2. Rats were exposed for 5.5 h to a 3 g field while ambient temperature (Ta) was varied. For the first 2 h, Ta was 25 degrees C; then Ta was raised to 34 degrees C for 1.5 h. During this period of warm exposure, Tc increased 4 degrees C in both RT and CA rats. Finally, Ta was returned to 25 degrees C for 2 h, and Tc decreased toward the levels measured prior to warm exposure. 3. In a second experiment at 3 g, RT and CA rats were exposed to cold (12 degrees C) after two hours at 25 degrees C. During the one hour cold exposure, Tc fell 1.5 degrees C in RT and 0.5 degree C in CA rats. After cold exposure, when ambient temperature was again 25 degrees C, Tc of RT and CA rats returned toward the levels measured prior to the thermal disturbance. 4. Rats appear to regulate their temperature, albeit at a lower level, in a 3 g field.

NASA Discipline Number 40-30↗
NASA NTRS1985

Growth and development of mice and rats conceived and reared at different G-intensities during chronic centrifugation

Prenatal and postnatal growth of rats conceived and reared at different G-intensities from 1.0G (earth gravity) to a maximum of 2.03G were compared. Prenatal growth was not generally impaired but the lung/body mass ratio of 22-day old fetuses at 2.03G was decreased significantly compared to 1.06 controls. Survival of neonatal rats was substantially reduced at 1.71G and 2.03G. Postnatal growth was decreased at the higher G-intensities and showed smaller or no effects at the lower G-intensities. Comparisons of organ/body mass ratios of hyper-G and 1.0G rats at 9 wks of age showed relatively few differences at the lower G-intensities. Postnatal growth of mice at 2.03G was suppressed during the neonatal period but recovered later so that after 9 wks the body mass of females reached and of males approached controls. Results of this preliminary study clearly show the influence of body mass in scaling the effects of hyper-G on the growth and development of and between different animal species.

Oyama, J.↗
NASA NTRS1984

Core temperature of tailless rats exposed to centrifugation

The role of the tail in the altered thermoregulation of rats during acute exposure to hypergravity was investigated, using groups of rats of two ages: 55 days (young) and 138 days (old). Rectal and foot temperature changes were measured in intact and tailless rats subjected to 1 h centrifugation of 2.8 G, with preceding (1 h) and following (1-3 h) 1 G periods. At 22 C, the loss of body heat from the tail per se does not measurably contribute to the hypothermia induced by hypergravity. However, the heat loss from the feet was greater in the tailless rats than in the intact rats from the young group of animals, although there was no significant difference between the tailless and intact rats in the old animal group. It is concluded that the inhibition of heat production is a significant factor in the hypothermia of centrifuged tailless rats, as it has been previously shown to be in the intact animals.

Monson, C. B.↗
NASA NTRS1983

Thermoregulation in cold- and noncold-acclimated rats cold exposed in hypergravic fields

The effect of hypergravity on thermoregulation processes is investigated experimentally in rats. Hooded male Long-Evans rats were kept for 6 weeks at 5 or 23 C (cold-acclimated and noncold-acclimated groups, CA and NCA) prior to testing. One test protocol comprised sequential 1-h exposures to 23 C at 1 G, 23 C at 3 G (in a 2.1-m radius centrifuge; -Gx), 8 C at 3 G, 8 C at 1 G, and finally 23 C at 1 G, with continuous measurement of the oxygen consumption. In a second protocol, restrained rats were exposed to 23 C at 1 G, 23 C at 3 G, and 10 C at 3 G, and core temperature changes were monitored. The results are presented in graphs and a table. Oxygen consumption doubled in both CA and NCA rats on exposure to cold at 1 G, but at 3 G NCA consumption decreased while CA consumption remained high. The CA rats were also more able to maintain core temperature at 3 G than the NCA rats. These differences are attributed to the nonshivering thermogenic processes developed in CA rats, which appear to be unaffected by hypergravity.

Horowitz, J. M.↗
NASA NTRS1983

Hypergravic fields and parallel controllers for thermoregulation

To test the proposal that mammals have parallel neurocontrollers for temperature regulation, Long-Evans hooded male rats were exposed to cold while in a 3-G field. When exposed to cold, these rats consumed 35 percent less oxygen/min at 3 G than they did when exposed to cold at 1 G. However, rats acclimated for 6 wk to 5 C consumed oxygen at the same rate during cold exposure at 3 G as at 1 G. Because cold-acclimated rats generate heat primarily by nonshivering thermogenesis while rats acclimated to room temperature rely to a greater extent on shivering, the 35 percent decrease in oxygen consumption of cold-exposed room-temperature rats in 3-G fields may reflect an inactivation of shivering. These oxygen consumption measurements, together with measurements of core and tail temperatures of rats in 3-G fields, are consistent with the proposal that neurocontrollers for thermoregulation are arranged in parallel and can be uncoupled by hypergravic fields.

Monson, C. B.↗
NASA NTRS1982

Restraint hypothermia in cold-exposed rats at 3 G and 1 G

The relationship between heat loss, heat production, and hypothermia was investigated in experiments with rats which determined if hypergravity affects heat production by altering oxygen consumption and if restraint modifies the ability of the rats to activate thermogenic mechanisms after cold exposure in a hypergravic field. Restrained and unrestrained rats were exposed for 1 hr periods to 1 G and 3 G at ambient temperatures of 24 C or 10 C, and the rate of oxygen consumption, the core temperatures, and the tail temperatures were measured. Results show that thermoregulatory mechanisms are impaired when rats are exposed to 3 G fields, and at 24 C as well as at 10 C this impairment leads to an inappropriate increase in heat loss.

Monson, C. B.↗