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Morrison, David

Publications and source records attributed to Morrison, David.

At least 19 records

Genome-wide association study of long COVID

Abstract Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association ofFOXP4with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

Genetics & Heredity

Tunguska Workshop: Applying Modern Tools to Understand the 1908 Tunguska Impact

A one-day workshop was held at NASA Ames Research Center, January 16, 2018, to re-examine the 1908 Tunguska impact using modern computational tools, many of them developed in response to the 2013 Chelyabinsk airburst. Twelve international experts gave presentations, with another 40 attending in-person or remotely. The most likely models for Tunguska converged on an energy of 10-20 Megatons, released in an airburst at a height of about 10 km. If the Tunguska impactor was a stony asteroid similar to Chelyabinsk, the diameter was roughly 50-80m. A comparison with current understanding of the population of asteroids in this size range indicates that the interval between such events is millennia, not centuries as had been concluded previously. The primary constraints on our understanding of Tunguska are the dearth of quantitative data, not weakness of the computational models. The workshop was sponsored by the NASA Ames Asteroid Threat Assessment Project and supported the NASA Planetary Defense Coordination Office.

Morrison, David

Contribution of Asteroid Generated Tsunami to the Impact Hazard

The long-standing uncertainty about the importance of asteroid-generated tsunami was addressed at a workshop in August 2016, co-sponsored by NASA and NOAA. Experts from NASA, NOAA, the DoE tri-labs (LLNL, SNL, and LANL), DHS, FEMA, and academia addressed the hazard of tsunami created by asteroid impacts, focusing primarily on NEAs with diameter less than 250m. Participants jointly identified key issues and shared information for nearly a year to coordinate their results for discussion at the workshop. They used modern computational tools to examine 1) Near-field wave generation by the impact; 2) Long-distance wave propagation; 3) Damage from coastal run-up and inundation, and associated hazard. The workshop resulted in broad consensus that the asteroid impact tsunami threat is not as great as previously thought.

Asteroid

Asteroid Generated Tsunami Workshop: Summary of NASA/NOAA Workshop

A two-day workshop on tsunami generated by asteroid impacts in the ocean resulted in a broad consensus that the asteroid impact tsunami threat is not as great as previously thought, that airburst events in particular are unlikely to produce significant damage by tsunami, and that the tsunami contribution to the global ensemble impact hazard is substantially less than the contribution from land impacts. The workshop, led by Ethiraj Venkatapathy and David Morrison of NASA Ames, was organized into three sessions: 1) Near-field wave generation by the impact; 2) Long distance wave propagation; 3) Damage from coastal run-up and inundation, and associated hazard. Workshop approaches were to compare simulations to understand differences in the results and gain confidence in the modeling for both formation and propagation of tsunami from asteroid impacts, and to use this information for preliminary global risk assessment. The workshop focus was on smaller asteroids (diameter less than 250m), which represent the most frequent impacts.

Asteroid

Asteroid Characterization Priorities for Planetary Defense

We propose a prioritized list of asteroid characterization needs for planetary defense. In particular, we consider the properties of asteroids that are of greatest interest for assessment of planetary defense options, including gravity tractors, kinetic impactors, and nuclear explosives. In addition, much of our discussion is relevant for impact assessments and subsequent emergency-response planning. Rather than intending this as a definitive answer, however, our purpose is to stimulate and focus disscussion regarding characterization needs for planetary defense, with a specific list as a starting point. A key theme is understanding the sensitivity of the outcome of an asteroid deflection or disruption effort to the asteroids physical properties.There is a range of previous work relevant to our topic, including some explicit discussions as well as many more that are implicitly relevant. We incorporate elements from such reports while extending them using our own experience and perspectives. After introducing our prioritized list, we provide further discussion on each element, with details on the relevance of each characteristic for modeling purposes, our rationale for the assigned priority, and examples of analyses that require improved characterization information. Our goal is to establish a framework that can be modified and adapted by the community for a variety of purposes, such as mission design and optimization, development of new measurement techniques, or prioritization of research efforts. The objective is to increase understanding and reduce uncertainties in the specific aspects of characterization that most benefit accurate assessments of practical techniques for planetary defense.

Miller, Paul

Kepler Planet Detection Mission: Introduction and First Results

The Kepler Mission is designed to determine the frequency of Earth-size and rocky planets in and near the habitable zone (HZ) of solar-like stars. The HZ is defined to be the region of space where a rocky planet could maintain liquid water on its surface. Kepler is the 10th competitively-selected Discovery Mission and was launched on March 6, 2009. Since completing its commissioning, Kepler has observed over 156,000 stars simultaneously and near continuously to search for planets that periodically pass in front of their host star (transit). The photometric precision is approximately 23 ppm for 50% of the 12th magnitude dwarf stars for an integration period of 6.5 hours. During the first 3 months of operation the photometer detected transit-like signatures from more than 200 stars. Careful examination shows that many of these events are false-positives such as small stars orbiting large stars or blends of target stars with eclipsing binary stars. Ground-based follow-up observations confirm the discovery of five new exoplanets with sizes between 0.37 andl.6 Jupiter radii (R(sub J)) and orbital periods ranging from 3.2 to 4.9 days. Ground-based observations with the Keck 1, Hobby-Ebberly, Hale, WIYN, MMT, Tillinghast, Shane, and Nordic Optical Telescopes are used to vet the planetary candidates and measure the masses of the putative planets. Observations of occultations and phase variations of hot, short-period planets such as HT-P-7b provide a probe of atmospheric properties. Asteroseismic analysis already shows the presence of p-mode oscillations in several stars. Such observations will be used to measure the mean stellar density and infer the stellar size and age. For stars too dim to permit asteroseismology, observations of the centroid motion of target stars will be used to measure the parallax and be combined with photometric measurements to estimate stellar sizes. Four open clusters are being observed to determine stellar rotation rates as a function of age and spectral type. Many different types of stellar variability are observed with unprecedented precision and over a wide range of time scales. Solar-like photometric variability of thousands of field stars is being studied to determine how photometric variability and the stellar rotation rates change with stellar age and metallicity. A wide variety of other astrophysical phenomena have also been observed. The data are being analyzed at the Ames Research Center and archived at the MAST at STScI. The Kepler Mission also supports a vigorous Guest Observer Program.

Borucki, William

Impacts and evolution: future prospects

The discipline of astrobiology includes the dynamics of biological evolution. One of the major ways that the cosmos influences life is through the catastrophic environmental disruptions caused when comets and asteroids collide with a planet. We now recognize that such impacts have caused mass extinctions and played a major role in determining the evolution of life on Earth. The time-averaged impact flux as a function of projectile energy can be derived from lunar cratering statistics as well as the current population of near Earth asteroids (NEAs). Effects of impacts of various energies can be modeled, using data from historic impacts [such as the Cretaceous-Tertiary (KT) impactor 65 million years ago] and the observed 1994 bombardment of Jupiter by fragments of Comet Shoemaker-Levy 9. It is of particular interest to find from such models that the terrestrial environment is highly vulnerable to perturbation from impacts, so that even such a small event as the KT impact (by a projectile 10-15 km in diameter) can lead to a mass extinction. Similar considerations allow us to model the effects of still smaller (and much more likely) impacts, down to the size of the asteroid that exploded over Tunguska in 1908 (energy approximately 10 megatons). Combining the impact flux with estimates of environmental and ecological effects reveals that the greatest contemporary hazard is associated with impactors near 1 million megatons in energy (approximately 2 km in diameter for an asteroid). The current impact hazard is significant relative to other natural hazards, and arguments can be developed to illuminate a variety of public policy issues. The first priority in any plan for defense against impactors is to survey the population of Earth-crossing NEAs and project their orbits forward in time. This is the purpose of the Spaceguard Survey, which has already found more than half of the NEAs >1 km in diameter. If there is an NEA on a collision course with Earth, it can be discovered and the impact predicted with decades or more of warning. It is then possible to consider how to deflect or disrupt the NEA. Unlike other natural hazards, the impact risk can be largely eliminated, given sufficient advanced knowledge to take action against the threatening projectile.

Directed Molecular Evolution

Dealing with the Asteroid Impact Hazard

The small fraction of the asteroids with Earth-crossing or Earth-approaching orbits is of special interest to us because many will eventually impact our planet. The time-averaged impact flux as a function of projectile energy can be derived from lunar cratering statistics, although we have little information on the possible variability of this flux over time. The effects of impacts of various energies can be modeled, using data from historic impacts (such as the KT impactor 65 million years ago), nuclear explosive testing, and the observed 1994 bombardment of Jupiter by fragments of comet Shoemaker-Levy 9. It is of particular interest to find from such models that the terrestrial environment is highly vulnerable to perturbation from impacts, so that even such a small event as the KT impact (by a projectile roughly 15 km in diameter) can lead to a mass extinction. Combining the impact flux with estimates of environmental and ecological effects reveals that the greatest contemporary hazard is associated with impactors near one million megatons energy. The current impact hazard is significant relative to other natural hazards, and arguments can be developed to illuminate a variety of public policy issues. These include the relative risk of different impact scenarios and the associated costs and probability of success of countermeasures. It is generally agreed that the first step is to survey and catalogue the thousand-or-so Near Earth Asteroids (NEAs), and we review the status of the Spaceguard NEA Survey. We compare the efficiency of various ground and space-based approaches and consider the challenges of international coordination and the problems and opportunities associated with communicating the results with the press and the public. It is also important to reflect on how the impact hazard might be dealt with by both national governments and international decision-making bodies, and to anticipate ways of mitigating the danger if a NEA were located on an apparent Earth-impact trajectory. As the most extreme known example of a natural hazard with low probability but severe global consequences. the NEA impact hazard calls for the most careful consideration and planning.

Morrison, David

Mass Movement and Landform Degradation on the Icy Galilean Satellites: Results of the Galileo Nominal Mission

The Galileo mission has revealed remarkable evidence of mass movement and landform degradation on the icy Galilean satellites of Jupiter. Weakening of surface materials coupled with mass movement reduces the topographic relief of landforms by moving surface materials down-slope. Throughout the Galileo orbiter nominal mission we have studied all known forms of mass movement and landform degradation of the icy galilean satellites, of which Callisto, by far, displays the most degraded surface. Callisto exhibits discrete mass movements that are larger and apparently more common than seen elsewhere. Most degradation on Ganymede appears consistent with sliding or slumping, impact erosion, and regolith evolution. Sliding or slumping is also observed at very small (100 m) scale on Europa. Sputter ablation, while probably playing some role in the evolution of Ganymede's and Callisto's debris layers, appears to be less important than other processes. Sputter ablation might play a significant role on Europa only if that satellite's surface is significantly older than 10(exp 8) years, far older than crater statistics indicate. Impact erosion and regolith formation on Europa are probably minimal, as implied by the low density of small craters there. Impact erosion and regolith formation may be important on the dark terrains of Ganymede, though some surfaces on this satellite may be modified by sublimation-degradation. While impact erosion and regolith formation are expected to operate with the same vigor on Callisto as on Ganymede, most of the areas examined at high resolution on Callisto have an appearance that implies that some additional process is at work, most likely sublimation-driven landform modification and mass wasting. The extent of surface degradation ascribed to sublimation on the outer two Galilean satellites implies that an ice more volatile than H2O is probably involved.

Moore, Jeffrey M.

Environmental Perturbations Caused by the Impacts of Asteroids and Comets

We review the major mechanisms proposed to cause extinctions at the Cretaceous-Tertiary geological boundary following an asteroid impact. We then discuss how the proposed extinction may relate to the impact of asteroids or comets in general. We discuss the limitations of these mechanisms in terms of the spatial scale that may be affected, and the time scale over which the effects may last. Our goal is to provide relatively simple prescriptions for evaluating the importance of colliding objects having a range of energies and compositions. We also identify the many uncertainties concerning the environmental effects of impacts. We conclude that, for impact energies below about 10(exp 4) Mts (megatons of TNT equivalent) - i.e., impact frequencies less than in 6 x 10(exp 4) yr, corresponding to comets and asteroids with diameters smaller than about 400 m and 650 m, respectively - blast damage, earthquakes, and fires should be important on a scale of 10(exp 4) or 10(exp 5) km (exp 2), which corresponds to the area damaged in many natural disasters of recent history. However, tsunami could be more damaging, flooding a kilometer of coastal plane over entire ocean basins. In the energy range of 10(exp 4) to 10 (exp 5) Mts (intervals up to 3 x 10(exp 5) yr; comets and asteroids with sizes up to 800 m and 1.5 km, respectively) water vapor injections and ozone loss become significant on the global scale. In the submicrometer dust injection fraction from the pulverized target material is much higher than is presently thought to be most likely, then dust injection could be important in this energy range.

Toon, Owen B.

Astrobiology: Study of the Living Universe

Astrobiology is defined as the study of the living universe. This endeavor encompasses the use of space to understand life's origin, evolution, and destiny in the universe. Life's origin refers to understanding the origin of life in the context of the origin and diversity of planetary systems. Life's evolution refers to understanding how living systems have adapted to Earth's changing environment, to the all-pervasive force of gravity, and how they may adapt to environments beyond Earth. Life's destiny refers to making long-term human presence in space a reality, and laying the foundation for understanding and managing changes in Earth's environment. This lecture will explore the development of this field of inquiry, the science questions to be examined, and the mechanisms available for participation by the scientific community.

DeVincenzi, Donald L.

Key Questions in Astrobiology

Astrobiology is a new name for a range of interdisciplinary studies related to life in the universe. The term is defined in the 1996 NASA Strategic Plan as 'The Study of the living universe. This field provides a scientific foundation for a multidisciplinary study of (1) the origin and distribution of life in the universe, (2) an understanding of the role of gravity in living systems, and (3) the study of the Earth's atmosphere and ecosystems.'

Morrison, David

NASA Space Missions to Asteroids: Protecting the Earth from NEO Impacts

There is now a general recognition of the hazard of impacts on Earth by comets and asteroids, but there is yet no consensus concerning international actions that should be taken to protect the planet from such impacts. An essential step in the analysis of the situation involves estimating the relative hazard posed by comets and asteroids of different sizes and orbits. All recent studies agree that the larger impacts pose the greater danger, and that our primary concern from the perspective of total risk should be on impacts that are large enough to cause global ecological catastrophe. These global catastrophes are also of special interest, since they (alone among natural disasters) have the potential to destroy civilization. Studies of the sensitivity of the Earth's environment suggest that the energy threshold energy for causing a global catastrophe is at about 1 million megatons, corresponding to impactor diameters of 1.5 to 2 km. This information leads naturally to a strategy of concentrating on the larger NEOs, say those 1 km or more in diameter. This is the rationale for the Spaceguard Survey, which must be the highest priority in mitigation efforts. The second question concerns the value of developing standing defensive systems that could deflect or destroy an incoming NEO. In the case of the asteroids larger than 1 km in diameter, no such system is needed, since there will be ample time (at least several decades) between the discovery of the threatening object by Spaceguard and the requirement to take action against it. In the case of objects smaller than 1 km diameter, development of defensive systems is not cost-effective; there are many greater dangers to persons and property that are much more urgent. Only in the case of large long-period comets is there a rationale for standing defense systems. The question is also raised whether the risks inherent in developing and maintaining a defense system might be greater than the impact risks it is intended to guard against. These and related issues are the focus of much current international debate on defense of the planet against NEO impacts. Meanwhile, the most critical issue remains the expansion of the telescopic search for NEOs.

Morrison, David

Multiple Core Galaxies

Nuclei of galaxies often show complicated density structures and perplexing kinematic signatures. In the past we have reported numerical experiments indicating a natural tendency for galaxies to show nuclei offset with respect to nearby isophotes and for the nucleus to have a radial velocity different from the galaxy's systemic velocity. Other experiments show normal mode oscillations in galaxies with large amplitudes. These oscillations do not damp appreciably over a Hubble time. The common thread running through all these is that galaxies often show evidence of ringing, bouncing, or sloshing around in unexpected ways, even though they have not been disturbed by any external event. Recent observational evidence shows yet another phenomenon indicating the dynamical complexity of central regions of galaxies: multiple cores (M31, Markarian 315 and 463 for example). These systems can hardly be static. We noted long-lived multiple core systems in galaxies in numerical experiments some years ago, and we have more recently followed up with a series of experiments on multiple core galaxies, starting with two cores. The relevant parameters are the energy in the orbiting clumps, their relative.masses, the (local) strength of the potential well representing the parent galaxy, and the number of cores. We have studied the dependence of the merger rates and the nature of the final merger product on these parameters. Individual cores survive much longer in stronger background potentials. Cores can survive for a substantial fraction of a Hubble time if they travel on reasonable orbits.

Miller, R.H.

An Assessment of Wall Effects in Low-Gravity Aerosol Experiments

Low-gravity aerosol experiments are currently being considered for research relating to a variety of science disciplines. One potential difficulty for these low-gravity experiments is the influence of the container on the aerosol's evolution, i.e., wall effects. In an attempt to understand the magnitude of the effects of containment on low-gravity aerosol experiments, this work compares three simulated environments: (1) a ground-based laboratory experiment environment, (2) a zero-gravity experiment environment of an orbiting facility, and (3) a spatially unbounded ideal aerosol environment (also with no gravity). This paper describes the five-dimensional model (three spatial dimensions, plus particle size and time) developed to describe the zero-gravity aerosol experiment environment, and compares the output of this model and the output of a model of an Earth-gravity aerosol experiment environment to a model of particle aggregation alone. The zero-gravity experiment model is found to be a much closer approximation to pure aggregation than the Earth-gravity aerosol experiment model.

Stratton, David M.

Large Solar Wind Disturbances During Late May and Early June, 1991

Solar wind data from the Ames experiment aboard the Pioneer Venus Orbiter, associated with a period of high solar activity that began at the end of May, 1991, are summarized and discussed. Some particularly large, strong shocks and solar ejecta were observed. The solar longitude of Venus, relative to associated flares. varies over a wide range, for a series of flares that produced X-rays that saturated the GOES X-ray counters.

Mihalov, J. D.

Photoevaporation of Disks Around Young Stars

Young massive stars produce sufficient Lyman continuum luminosity phi to have a significant effect on the structure and evolution of the accretion disks surrounding diem. We show that inside a critical disk radius r(sub g), an isothermal 10(exp 4) K atmosphere forms with a scale height that increases with r(sup3/2) for r less than or equal to r(sub g). For r less than or equal to r(sub g), the diffuse field caused by hydrogen recombinations to the ground state in the atmosphere produces a steadily evaporating disk. The mass loss from this outer region of the disk is of order 10(exp -5) Mo/yr phi(sub 49)1/2, where phi(sub 49) is defined as phi/10(exp 49) photons/s. The mass loss has two important consequences. First, the slow (10-50 km/s) wind that results may explain the long life of unresolved ultracompact HII regions. Secondly, the dependence on phi implies that accretion through the disk onto the star will be quenched once the photoevaporation rate exceeds the accretion rate. This may act to limit the mass of the forming star.

Hollenbach, David

The Infrared Reflection Nebula Around the Protostellar System in S140

We have studied the protostellar system in S140 at 2.2, 3.1 and 3.45 microns using a 128x128 InSb array at the Lick Observatory 3m telescope. Besides the protostellar sources, the data reveal a bright infrared reflection nebula. We have developed a simple model of this region and derived the physical conditions. IRSI is surrounded by a dense dusty disk viewed almost edge-on. Photons leaking out through the poles illuminate almost directly north and south the inner edge of a surrounding shell of molecular gas, Analysis of the observed colors and intensities of the NIR light, using Mie scattering theory, reveal that the dust grains in the molecular cloud are somewhat larger than in the general diffuse interstellar medium. Moreover, the incident light has a "cool" color temperature, approximately equals 800K, and likely originates from a dust photosphere close to the protostar. Finally, we find little H2O ice associated with the dusty disk around IRSI. Most of the 3.1 micron ice extinction arises instead from cool intervening molecular cloud material. We have compared our infrared dust observations with millimeter and radio observations of molecular gas associated with this region. The large scale structure observable in the molecular gas is indicative of the interaction between the protostellar wind and the surrounding molecular cloud rather than the geometry of the protostellar disk. We conclude that S140 is a young blister formed by this outflow on the side of a molecular cloud and viewed edge-on.

Harker, D.