Learning quantum systems via out-of-time-order correlators
Not Available
Schuster, Thomas (ORCID:0000000220846586)↗
Engineering topics
O'Brien, Thomas
Publications and source records attributed to O'Brien, Thomas.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the LDHA active site. Finally, this led to the identification of a potent, cell-active hydroxylactam inhibitor exhibiting an in vivo pharmacokinetic profile suitable for mouse tumor xenograft study.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Missions to Triton and Pluto using a Hopper Vehicle with In-Situ Refueling
The Triton Hopper is a NASA Innovative Advanced Concepts (NIAC) project to design a mission to not merely land, but repeatedly fly across the surface of Triton, utilizing the volatile surface ices (primarily nitrogen) as propellant for a radioisotope-heated thermal rocket engine to launch across the surface and explore all the moon's varied terrain. An engineering design study of the vehicle and mission was done. With a calculated range of 20 km per hop, equator-to-pole mobility can be achieved over a primary mission duration of 2 years. Using Nuclear Electric Propulsion for the transfer vehicle, the same concept can be applied for a mission to the surface of Pluto.
Landis, Geoffrey A.↗