Engineering topics

Park, Chan

Publications and source records attributed to Park, Chan.

4 records

DOE OSTI2024

Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families

Broadly reactive antibodies that target sequence-diverse antigens are of interest for vaccine design and monoclonal antibody therapeutic development because they can protect against multiple strains of a virus and provide a barrier to evolution of escape mutants. Using LIBRA-seq (linking B cell receptor to antigen specificity through sequencing) data for the B cell repertoire of an individual chronically infected with human immunodeficiency virus type 1 (HIV-1), we identified a lineage of IgG3 antibodies predicted to bind to HIV-1 Envelope (Env) and influenza A Hemagglutinin (HA). Two lineage members, antibodies 2526 and 546, were confirmed to bind to a large panel of diverse antigens, including several strains of HIV-1 Env, influenza HA, coronavirus (CoV) spike, hepatitis C virus (HCV) E protein, Nipah virus (NiV) F protein, and Langya virus (LayV) F protein. We found that both antibodies bind to complex glycans on the antigenic surfaces. Antibody 2526 targets the stem region of influenza HA and the N-terminal domain (NTD) region of SARS-CoV-2 spike. A crystal structure of 2526 Fab bound to mannose revealed the presence of a glycan-binding pocket on the light chain. Antibody 2526 cross-reacted with antigens from multiple pathogens and displayed no signs of autoreactivity. These features distinguish antibody 2526 from previously described glycan-reactive antibodies. Further study of this antibody class may aid in the selection and engineering of broadly reactive antibody therapeutics and can inform the development of effective vaccines with exceptional breadth of pathogen coverage.

Microbiology↗

DOE OSTI2021

Energy System Transitions and Low-Emission Pathways in Australia, Brazil, Canada, China, EU-28, India, Indonesia, Japan, Republic of Korea, Russia, and United States

The Paris Agreement invited Parties to submit long-term, low-emission development strategies. This study presents national low-emission scenarios to inform such strategies for Australia, Brazil, Canada, China, EU, India, Indonesia, Japan, Russia, Republic of Korea and the USA. The study uses country-level energy–economy and integrated assessment models (IAMs) that incorporate detailed and disaggregated representations of the energy demand and supply systems that are difficult to capture in global IAMs. Models were used to explore low-carbon pathways up to 2050, providing insights in their implications for country emissions, energy system restructuring, energy–economy indicators and system costs. The analysis shows that the low-carbon scenarios of most economies studied here are consistent with pathways limiting global warming to below 2 °C.

Fragkos, Panagiotis↗

DOE OSTI2020

Impacts of Climate Change on Energy Systems in Global and Regional Scenarios

A growing number of studies report the impact of climate change on the supply, demand, transport, and cost of energy. However, there is lack of comprehensive overview and understanding of climate change impacts on energy across technologies and scales. Here, we conduct a systematic assessment of results from 186 papers on potential impacts of climate change on energy. Results show that increased cooling demand and decreased heating demand is anticipated globally. Similarly, increases in bio-energy and hydro power and a possible decrease in thermal electricity supply is projected. Overall changes in heating and cooling demand, increased thermal cooling, and reduced hydropower supply in Europe, India and Latin America are projected 35 at the regional scale. Furthermore, our review revealed that studies use a wide range of inconsistent methods and data sources. To move forward, the study proposes a consistent multi-model assessment framework for a comprehensive understanding of climate impacts on energy.

Yalew, Seleshi G.↗

NASA NTRS1993

Hubble Space Telescope EVA Power Ratchet Tool redesign

The Power Ratchet Tool (PRT) is a self contained, power-driven, 3/8 inch drive ratchet wrench which will be used by astronauts during Extravehicular Activities (EVA). This battery-powered tool is controlled by a dedicated electonic controller. The PRT was flown during the Hubble Space Telescope (HST) Deployment Mission STS-31 to deploy the solar arrays if the automatic mechanisms failed. The PRT is currently intended for use during the first HST Servicing Mission STS-61 as a general purpose power tool. The PRT consists of three major components; the wrench, the controller, and the battery module. Fourteen discrete combinations of torque, turns, and speed may be programmed into the controller before the EVA. The crewmember selects the desired parameter profile by a switch mounted on the controller. The tool may also be used in the manual mode as a non-powered ratchet wrench. The power is provided by a silver-zinc battery module, which fits into the controller and is replaceable during an EVA. The original PRT did not meet the design specification of torque output and hours of operation. To increase efficiency and reliability the PRT underwent a redesign effort. The majority of this effort focused on the wrench. The original PRT drive train consisted of a low torque, high speed brushless DC motor, a face gear set, and a planocentric gear assembly. The total gear reduction was 300:1. The new PRT wrench consists of a low speed, high torque brushless DC motor, two planetary gear sets and a bevel gear set. The total gear reduction is now 75:1. A spline clutch has also been added to disengage the drive train in the manual mode. The design changes to the controller will consist of only those modifications necessary to accomodate the redesigned wrench. The battery design will be unaffected.

Richards, Paul W.↗