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Paul, B.

Publications and source records attributed to Paul, B..

Searching for beyond the Standard Model physics using the improved description of 100 Mo $2\nu \beta \beta$ decay spectral shape with CUPID-Mo

The current experiments searching for neutrinoless double-β ($0\nu \beta \beta$) decay also collect large statistics of Standard Model allowed two-neutrino double-β ($2\nu \beta \beta$ ) decay events. These can be used to search for Beyond Standard Model (BSM) physics via $2\nu \beta \beta$ decay spectral distortions. 100 Mo has a natural advantage due to its relatively short half-life, allowing higher $2\nu \beta \beta$ decay statistics at equal exposures compared to the other isotopes. We demonstrate the potential of the dual read-out bolometric technique exploiting a 100 Mo exposure of 1.47 kg years, acquired in the CUPID-Mo experiment at the Modane underground laboratory (France). We set limits on $0\nu \beta \beta$ decays with the emission of one or more Majorons, on $2\nu \beta \beta$ decay with Lorentz violation, and $2\nu \beta \beta$ decay with a sterile neutrino emission. In this analysis, we investigate the systematic uncertainty induced by modeling the $2\nu \beta \beta$ decay spectral shape parameterized through an improved model, an effect never considered before. This work motivates searches for BSM processes in the upcoming CUPID experiment, which will collect the largest amount of $2\nu \beta \beta$ decay events among the next-generation experiments.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of the 2 ν β β Decay Rate and Spectral Shape of Mo 100 from the CUPID-Mo Experiment

Neutrinoless double beta decay (0νββ) is a yet unobserved nuclear process that would demonstrate Lepton number violation, a clear evidence of beyond standard model physics. The process two neutrino double beta decay (2νββ) is allowed by the standard model and has been measured in numerous experiments. In this Letter, we report a measurement of 2νββ decay half-life of 100 Mo to the ground state of 100 Ru of [7.07±0.02(stat)±0.11(syst)]×10 18 yr by the CUPID-Mo experiment. With a relative precision of ±1.6% this is the most precise measurement to date of a 2νββ decay rate in 100 Mo. In addition, we constrain higher-order corrections to the spectral shape, which provides complementary nuclear structure information. We report a novel measurement of the shape factor ξ 3,1 =0.45±0.03(stat)±0.05(syst) based on a constraint on the ratio of higher-order terms from theory, which can be reliably calculated. This is compared to theoretical predictions for different nuclear models. Finally, we also extract the first value for the effective axial vector coupling constant obtained from a spectral shape study of 2νββ decay.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

The background model of the CUPID-Mo $0\nu\beta\beta$ experiment

CUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation 0vββ decay experiment, CUPID. It consisted of an array of 20 enriched Li 2 100 MoO 4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the 2vββ decay and other processes with high precision. We also measure the radio-purity of the Li 2 100 MoO 4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.7 $^{+0.9}_{-0.8}$ (stat) $^{+1.5}_{-0.7}$ (syst) x 10 -3 counts/ ΔE FWHM / mol iso / year the lowest in a bolometric Ovββ decay experiment.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

New measurement of double- β decays of Mo 100 to excited states of Ru 100 with the CUPID-Mo experiment

The CUPID-Mo experiment, located at Laboratoire Souterrain de Modane (France), was a demonstrator experiment for CUPID. It consisted of an array of 20 Li 2 100 MoO 4 (LMO) calorimeters each equipped with a Ge light detector (LD) for particle identification. In this work, we present the result of a search for two-neutrino and neutrinoless double beta decays of 100 Mo to the first 0 + and 2 + excited states of 100 Ru using the full CUPID-Mo exposure (2.71 kg yr of LMO). We measure the half-life of 2νββ decay to the $0^+_1$ state as $T^{2ν→0^+_1}_{1/2}$ = (7.5 ± 0.8 (stat.) $^{+0.4}_{-0.3}$ (syst.)) × 10 20 yr. The bolometric technique enables measurement of the electron energies as well as the gamma rays from nuclear de-excitation and this allows us to set new limits on the two-neutrino decay to the $2^+_1$ state of $T^{2ν→2^+_1}_{1/2}$ > 4.4×10 21 yr (90% c.i.) and on the neutrinoless modes of $T^{0ν→2^+_1}_{1/2}$ > 2.1×10 23 yr (90% c.i.), $T^{0ν→0^+_1}_{1/2}$ > 1.2 × 10 23 yr (90% c.i.). Information on the electrons spectral shape is obtained which allows us to make the first comparison of the single state (SSD) and higher state (HSD) 2νββ decay models for the $0^+_1$ excited state of 100 Ru.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Final results on the $$0\nu \beta \beta $$ decay half-life limit of $$^{100}$$Mo from the CUPID-Mo experiment

Abstract The CUPID-Mo experiment to search for 0 $$\nu \beta \beta $$ ν β β decay in $$^{100}$$ 100 Mo has been recently completed after about 1.5 years of operation at Laboratoire Souterrain de Modane (France). It served as a demonstrator for CUPID, a next generation 0 $$\nu \beta \beta $$ ν β β decay experiment. CUPID-Mo was comprised of 20 enriched $$\hbox {Li}_{{2}}$$ Li 2 $$^{100}$$ 100 $$\hbox {MoO}_4$$ MoO 4 scintillating calorimeters, each with a mass of $$\sim 0.2$$ ∼ 0.2 kg, operated at $$\sim 20$$ ∼ 20 mK. We present here the final analysis with the full exposure of CUPID-Mo ( $$^{100}$$ 100 Mo exposure of 1.47 $$\hbox {kg} \times \hbox {year}$$ kg × year ) used to search for lepton number violation via 0 $$\nu \beta \beta $$ ν β β decay. We report on various analysis improvements since the previous result on a subset of data, reprocessing all data with these new techniques. We observe zero events in the region of interest and set a new limit on the $$^{100}$$ 100 Mo 0 $$\nu \beta \beta $$ ν β β decay half-life of $$T_{1/2}^{0\nu }$$ T 1 / 2 0 ν $$> {1.8}\times 10^{24}$$ > 1.8 × 10 24 year (stat. + syst.) at 90% CI. Under the light Majorana neutrino exchange mechanism this corresponds to an effective Majorana neutrino mass of $$\left $$ m β β $$<~{(0.28{-}0.49)} $$ < ( 0.28 - 0.49 ) eV, dependent upon the nuclear matrix element utilized.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

New Limit for Neutrinoless Double-Beta Decay of 100 Mo from the CUPID-Mo Experiment

The CUPID-Mo experiment at the Laboratoire Souterrain de Modane (France) is a demonstrator for CUPID, the next-generation ton-scale cryogenic $0\nu\beta\beta$ experiment. It consists of a 4.2 kg array of 20 enriched Li$_{2}$$^{100}$MoO$_4$ scintillating bolometers to search for the lepton number violating process of $0\nu\beta\beta$ decay in $^{100}$Mo. With more than one year of operation (2.16 kg$\times$yr of physics data), no event in the region of interest and hence no evidence for $0\nu\beta\beta$ is observed. We report a new limit on the half-life of $0\nu\beta\beta$ decay in $^{100}$Mo of $T_{1/2} > 1.5 \times 10^{24}\,$yr at 90 % C.I. The limit corresponds to an effective Majorana neutrino mass $\langle m_{\beta\beta} \rangle$ $<$ (0.3--0.5)$\,$eV, dependent on the nuclear matrix element in the light Majorana neutrino exchange interpretation.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Pulse shape discrimination in CUPID-Mo using principal component analysis

CUPID-Mo is a cryogenic detector array designed to search for neutrinoless double-beta decay ($0\nu\beta\beta$) of $^{100}$Mo. It uses 20 scintillating $^{100}$Mo-enriched Li$_2$MoO$_4$ bolometers instrumented with Ge light detectors to perform active suppression of $\alpha$ backgrounds, drastically reducing the expected background in the $0\nu\beta\beta$ signal region. As a result, pileup events and small detector instabilities that mimic normal signals become non-negligible potential backgrounds. These types of events can in principle be eliminated based on their signal shapes, which are different from those of regular bolometric pulses. We show that a purely data-driven principal component analysis based approach is able to filter out these anomalous events, without the aid of detector response simulations.

47 OTHER INSTRUMENTATION↗

The CUPID-Mo experiment for neutrinoless double-beta decay: performance and prospects

CUPID-Mo is a bolometric experiment to search for neutrinoless double-beta decay ($0\nu\beta\beta$) of $^{100}$Mo. In this article, we detail the CUPID-Mo detector concept, assembly, installation in the underground laboratory in Modane in 2018, and provide results from the first datasets. The demonstrator consists of an array of 20 scintillating bolometers comprised of $^{100}$Mo-enriched 0.2 kg Li$_2$MoO$_4$ crystals. The detectors are complemented by 20 thin cryogenic Ge bolometers acting as light detectors to distinguish $\alpha$ from $\gamma$/$\beta$ events by the detection of both heat and scintillation light signals. We observe good detector uniformity, facilitating the operation of a large detector array as well as excellent energy resolution of 5.3 keV (6.5 keV) FWHM at 2615 keV, in calibration (physics) data. Based on the observed energy resolutions and light yields a separation of $\alpha$ particles at much better than 99.9\% with equally high acceptance for $\gamma$/$\beta$ events is expected for events in the region of interest for $^{100}$Mo $0\nu\beta\beta$. We present limits on the crystals' radiopurity ($\leq$3 $\mu$Bq/kg of $^{226}$Ra and $\leq$2 $\mu$Bq/kg of $^{232}$Th). Based on these initial results we also discuss a sensitivity study for the science reach of the CUPID-Mo experiment, in particular, the ability to set the most stringent half-life limit on the $^{100}$Mo $0\nu\beta\beta$ decay after half a year of livetime. In conclusion, the achieved results show that CUPID-Mo is a successful demonstrator of the technology - developed in the framework of the LUMINEU project - selected for the CUPID experiment, a proposed follow-up of CUORE, the currently running first tonne-scale cryogenic $0\nu\beta\beta$ experiment.

100Mo↗

Effect of strain on evolution of dynamic recrystallization in Nb-1 wt%Zr-0.1 wt%C alloy at 1500 and 1600 °C

Uniaxial compression tests were carried out on Nb-1 wt%Zr-0.1 wt%C alloy at temperature of 1500 and 1600 °C and strain rate of 0.1 s{sup −1} to study the evolution of dynamic recrystallization with strain. Electron back scatter diffraction was used to quantify the microstructural evolution. Nb-1Zr-0.1C alloy showed a necklace structure at a strain of 0.9 when deformed at 1500 °C and at strain of 0.6 when deformed at 1600 °C, both at strain rate of 0.1 s{sup −1}. This suggested the occurrence of dynamic recrystallization. At 1500 °C and strain of 0.9 the local average misorientation and the grain orientation spread was low confirming the presence of dynamic recrystallization at this deformation condition. At both 1500 and 1600 °C and all measured strains the recrystallized grains had a strong fiber component of <001>. - Highlights: • Necklace formation of dynamically recrystallized grains occurred at strain of 0.6 and 0.9 for 1500 and 1600 °C, respectively. • Equiaxed microstructures were seen with increase in strain for both 1500 and 1600 °C. • At large strains the predominant recrystallized texture evolved to <001> pole.

36 MATERIALS SCIENCE↗

Iron addiction: a novel therapeutic target in ovarian cancer

Ovarian cancer is a lethal malignancy that has not seen a major therapeutic advance in over 30 years. We demonstrate that ovarian cancer exhibits a targetable alteration in iron metabolism. Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients with high grade but not low grade serous ovarian cancer. A similar profile of decreased FPN and increased TFR1 is observed in a genetic model of ovarian cancer tumor-initiating cells (TICs). The net result of these changes is an accumulation of excess intracellular iron and an augmented dependence on iron for proliferation. A forced reduction in intracellular iron reduces the proliferation of ovarian cancer TICs in vitro, and inhibits both tumor growth and intraperitoneal dissemination of tumor cells in vivo. Some mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6). Here, we show that the iron dependence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron-dependent cell death (ferroptosis) as well as iron chelators, and thus creates a metabolic vulnerability that can be exploited therapeutically.

59 BASIC BIOLOGICAL SCIENCES↗

A WOUND CARE AND INTRAVENOUS ACCESS SUMMIT FOR ON-ORBIT CARE

Wound care issues and the ability to establish intravenous (IV) access among injured or ill crew members are a source of concern for NASA flight surgeons. Indeed, the microgravity environment and the remote nature of the International Space Station (ISS) pose unique challenges in diagnosing and treating an injured astronaut. Therefore, it is necessary to identify and adapt the best evidence based terrestrial practices regarding wound care, hemostasis, and IV access for use on the ISS. Methods: A panel of consultants was convened to evaluate the adequacy of the current ISS in-flight medical system for diagnosis and treatment of wounds and establishing IV access by a nonclinician crew medical officer. Participants were acknowledged experts in terrestrial wound care and/or operational medicine. Prior to the meeting, each panelist was encouraged to participate in a pre-summit online forum. Results: Eight external experts participated in a face-to-face meeting held at NASA-Johnson Space Center. Recommendations were made to augment the space station pharmacopoeia, as well as current wound care diagnostic, therapeutic, and deorbit criteria protocols. Additionally, suggestions were offered regarding IV access techniques and devices for use in the microgravity environment. Discussion: The results of the expert panel provide an evidence-based approach to the diagnosis and care of wounds in an injured astronaut on aboard the ISS. The results of the panel underscored the need for further research in wound therapy and IV access devices.

Scheuring, R.↗

Flow energizers. Task A

The effects of a propeller slipstream on the wing laminar boundary are being investigated. Hot-wire velocity sensor measurements have been performed in flight and in a wind tunnel. It is shown that the boundary layer cycles between a laminar state and a turbulent state at the propeller blade passage rate. The cyclic length of the turbulent state increases with decreasing laminar stability. Analyses of the time-varying velocity profiles show the turbulent state to lie in a transition region between fully laminar and fully turbulent. The observed cyclic boundary layer has characteristics similar to relaminarizing flow and laminar flow with external turbulence.

Ward, D.↗