Recombinant host cells for the production of malonate
Systems and methods for the production of malonate in recombinant host cells.
Engineering topics
Publications and source records attributed to Steen, Eric J..
Systems and methods for the production of malonate in recombinant host cells.
Systems and methods for the production of malonate in recombinant host cells.
The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.
Systems and methods for the production of malonate in recombinant host cells.