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Stuart M. C. Lee

Publications and source records attributed to Stuart M. C. Lee.

8 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2022

Noninvasive Indicators of Intracranial Pressure Before, During, and After Long-Duration Spaceflight

Weightlessness induces a cephalad shift of blood and cerebrospinal fluid that may increase intracranial pressure (ICP) during spaceflight, while lower body negative pressure (LBNP) may provide an opportunity to caudally redistribute fluids and lower ICP. To investigate the effects of spaceflight and LBNP on noninvasive indicators of ICP (nICP), we studied thirteen crewmembers before and after spaceflight in seated, supine, and 15° head-down tilt postures, and at ~45 and ~150 days of spaceflight with and without 25 mmHg LBNP. We used 4 techniques to quantify nICP: cerebral and cochlear fluid pressure (CCFP), otoacoustic emissions (OAE), ultrasound measures of optic nerve sheath diameter (ONSD), and ultrasound-based internal jugular vein pressure (IJVp). On flight day 45, two nICP measures were lower than preflight supine posture (CCFP: mean difference -98.5 -nl [CI: -190.8 to -6.1 -nl], p = 0.037]; OAE: -19.7 degrees [CI: -10.4 to -29.1 degrees], p < 0.001), but not significantly different from preflight seated measures. Conversely, ONSD was not different than any preflight posture, whereas IJVp was significantly greater than preflight seated measures (14.3 mmHg [CI: 10.1 to 18.5mmHg], p < 0.001), but not significantly different than preflight supine measures. During spaceflight, acute LBNP application did not cause a significant change in nICP indicators. These data suggest that during spaceflight nICP is not elevated above values observed in the seated posture on Earth. Invasive measures would be needed to provide absolute ICP values and more precise indications of ICP change during various phases of spaceflight.

Jessica V. Jasien↗
NASA NTRS2020

Artemis Sustained Translational Acceleration Limits: Human Tolerance Evidence from Apollo to ISS

The designers of the next generation of lunar landers may adopt novel, crew-body orientations outside of our flight history or applied to flight durations and environments outside of our experience. Current sustained translational acceleration requirements in NASA-STD-3001 are applicable only to crewmembers in a seated posture and are thus inadequate to address human tolerance in non-seated configurations. Initial designs for the Apollo Lunar Module (LM) included seats for both commander and pilot; however, these were subsequently removed from the vehicle due to mass constraints and a willingness to accept the unknown risks for short-duration missions given the limited human physiologic data at the time. In the years since Apollo, our evidence base has grown immensely. Initial Artemis mission timelines under consideration will be longer than the longest Apollo mission, by a significant margin, with timeframes more analogous to longer Space Shuttle missions. Given the incidence of postflight orthostatic intolerance following shuttle missions, a significant risk may exist for lander design(s) pursuing a standing crew configuration similar to Apollo LM. New sustained translational acceleration limits developed to address this risk are presented herein. These limits were derived from evaluations of Apollo biomedical and flight profile data during lunar descent and ascent operations, Soyuz and Space Shuttle flight profile and post-landing biomedical data, and analogue bed rest post-exposure data on orthostatic intolerance.

James M. Pattarini↗
NASA NTRS2003

Use of a Slick-Plate as a Contingency Exercise Surface for the Treadmill With Vibration Isolation System

The treadmill with vibration isolation system (TVIS) was developed to counteract cardiovascular, musculoskeletal, and neurovestibular deconditioning during long-duration missions to the International Space Station (ISS). However, recent hardware failures have necessitated the development of a short-term, temporary contingency exercise countermeasure for TVIS until nominal operations could be restored. The purpose of our evaluation was twofold: 1) to examine whether a slick-plate/contingency exercise surface (CES) could be used as a walking/running surface and could elicit a heart rate (HR) greater than or equal to 70% HR maximum and 2) to determine the optimal hardware configuration, in microgravity, to simulate running/walking in a 1-g environment. One subject (male) participated in the slick surface evaluation and two subjects (one male, one female) participated in the microgravity evaluation of the slick surface configuration. During the slick surface evaluation, the subject was suspended in a parachute harness and bungee cord configuration to offset the subject's body weight. Using another bungee cord configuration, we added a vertical load back to the subject, who was then asked to run for 20 minutes on the slick surface. The microgravity evaluation simulated the ISS TVIS, and we evaluated two different slick surfaces (Teflon surface and an aluminum surface coated with Tufram) for use as a CES. We evaluated each surface with the subject walking and running, with and without a handrail, and while wearing either socks or nylon booties over shoes. In the slick surface evaluation, the subject ran for 20 minutes and reached a maximum HR of 170 bpm. In the microgravity evaluation, the subjects chose the aluminum plate coated with Tufram as the CES, while wearing a pair of nylon booties over running shoes and using a handrail, as the optimal hardware configuration. The results indicate that the CES may provide an interim capability to counteract aerobic deconditioning until TVIS can be returned to an operational status. No indices of musculoskeletal or neurovestibular deconditioning were evaluated. Future studies are needed to validate the efficacy of CES in countering aerobic deconditioning and the effects, if any, on musculoskeletal and neurovestibular deconditioning.

James A. Loehr↗
NASA NTRSDate not supplied

Reply to Greaves et al.

Explore the source record for details and available documents.

Stuart M. C. Lee↗
NASA NTRSDate not supplied

Cardiovascular Responses to Daily Use of Lower Body Negative Pressure During 30 Days of Strict Head-Down Tilt Bedrest

The purpose of this study was to (1) measure the heart rate (HR) and mean arterial pressure (MAP) response and subject tolerance before and during twice daily use of 3 hours of 25 mmHg LBNP during 30 days of HDTBR and (2) determine if this level of LBNP during HDTBR would reverse the headward fluid shift to a similar degree as upright posture.

Jason R. Lytle↗