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DOE OSTI2025

Author Correction: A universal language for finding mass spectrometry data patterns

Correction to: Nature Methodshttps://doi.org/10.1038/s41592-025-02660-z, published online 12 May 2025. This article was originally published under standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature America, Inc.). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article.

Damiani, Tito↗

DOE OSTI2025

A universal language for finding mass spectrometry data patterns

Despite being information rich, the vast majority of untargeted mass spectrometry data are underutilized; most analytes are not used for downstream interpretation or reanalysis after publication. The inability to dive into these rich raw mass spectrometry datasets is due to the limited flexibility and scalability of existing software tools. Here, in this study, we introduce a new language, the Mass Spectrometry Query Language (MassQL), and an accompanying software ecosystem that addresses these issues by enabling the community to directly query mass spectrometry data with an expressive set of user-defined mass spectrometry patterns. Illustrated by real-world examples, MassQL provides a data-driven definition of chemical diversity by enabling the reanalysis of all public untargeted metabolomics data, empowering scientists across many disciplines to make new discoveries. MassQL has been widely implemented in multiple open-source and commercial mass spectrometry analysis tools, which enhances the ability, interoperability and reproducibility of mining of mass spectrometry data for the research community.

Damiani, Tito [Czech Academy of Sciences (CAS), Pr↗

NASA NTRS1990

Acoustic radiation from lifting airfoils in compressible subsonic flow

The far field acoustic radiation from a lifting airfoil in a three-dimensional gust is studied. The acoustic pressure is calculated using the Kirchhoff method, instead of using the classical acoustic analogy approach due to Lighthill. The pressure on the Kirchhoff surface is calculated using an existing numerical solution of the unsteady flow field. The far field acoustic pressure is calculated in terms of these values using Kirchhoff's formula. The method is validated against existing semi-analytical results for a flat plate. The method is then used to study the problem of an airfoil in a harmonic three-dimensional gust, for a wide range of Mach numbers. The effect of variation of the airfoil thickness and angle of attack on the acoustic far field is studied. The changes in the mechanism of sound generation and propagation due to the presence of steady loading and non-uniform mean flow are also studied.

Atassi, Hafiz M.↗

NASA NTRS1990

Acoustic radiation from lifting airfoils in compressible subsonic flow

The far field acoustic radiation from a lifting airfoil in a three-dimensional gust is studied. The acoustic pressure is calculated using the Kirchhoff method, instead of using the classical acoustic analogy approach due to Lighthill. The pressure on the Kirchhoff surface is calculated using an existing numerical solution of the unsteady flow field. The far field acoustic pressure is calculated in terms of these values using Kirchhoff's formula. The method is validated against existing semi-analytical results for a flat plate. The method is then used to study the problem of an airfoil in a harmonic three-dimensional gust, for a wide range of Mach numbers. The effect of variation of the airfoil thickness and angle of attack on the acoustic far field is studied. The changes in the mechanism of sound generation and propagation due to the presence of steady loading and nonuniform mean flow are also studied.

Atassi, Hafiz M.↗