Ice formation and its elimination in cryopreservation of oocytes
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Science & Technology - Other Topics↗
Engineering topics
Thorne, Robert
Publications and source records attributed to Thorne, Robert.
Development of Tools to Improve Sample Preparation and Outcomes in Cryogenic Electron Microscopy Single Particle Analysis and Micro-electron Diffraction
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59 BASIC BIOLOGICAL SCIENCES↗
Megawatt pulses from an all-fiber and self-starting femtosecond oscillator
Mamyshev oscillators produce high-performance pulses, but technical and practical issues render them unsuitable for widespread use. Here we present a Mamyshev oscillator with several key design features that enable self-starting operation and unprecedented performance and simplicity from an all-fiber laser. The laser generates 110 nJ pulses that compress to 40 fs and 80 nJ with a grating pair. The pulse energy and duration are both the best achieved by a femtosecond all-fiber laser to date, to our knowledge, and the resulting peak power of 1.5 MW is 20 times higher than that of prior all-fiber, self-starting lasers. Finally, the simplicity of the design, ease of use, and pulse performance make this laser an attractive tool for practical applications.
47 OTHER INSTRUMENTATION↗
Publishing statistical models: Getting the most out of particle physics experiments
The statistical models used to derive the results of experimental analyses are of incredible scientific value and are essential information for analysis preservation and reuse. In this paper, we make the scientific case for systematically publishing the full statistical models and discuss the technical developments that make this practical. By means of a variety of physics cases - including parton distribution functions, Higgs boson measurements, effective field theory interpretations, direct searches for new physics, heavy flavor physics, direct dark matter detection, world averages, and beyond the Standard Model global fits - we illustrate how detailed information on the statistical modelling can enhance the short- and long-term impact of experimental results.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
Starting dynamics of a linear-cavity femtosecond Mamyshev oscillator
Mamyshev oscillators can generate high-power femtosecond pulses, but starting a mode-locked state has remained a major challenge due to the suppression of continuous-wave lasing. Here, we study the starting dynamics of a linear Mamyshev oscillator designed to generate high-power femtosecond pulses while avoiding component damage. Reliable starting to stable mode-locking is achieved with a combination of modulation of the pump power and shifting of a filter passband. The starting process is automated, with full electronic control. The laser delivers 21-nJ pulses that are dechirped to 65 fs in duration outside the cavity.
Chen, Yi-Hao (ORCID:0000000244001983)↗