Vailionis, Jason L. | Search NASA

DOE OSTI2023

Manipulating Fermentation Pathways in the Hyperthermophilic Archaeon Pyrococcus furiosus for Ethanol Production up to 95°C Driven by Carbon Monoxide Oxidation

Previously, the highest temperature for biological ethanol production was 85°C. Here, we have engineered ethanol production at 95°C by the hyperthermophilic archaeon Pyrococcus furiosus .

Biotechnology & Applied Microbiology↗

DOE OSTI2023

Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus

The bio-based production of organic chemicals provides a sustainable alternative to fossil-based production in the face of today’s climate challenges. In this work, we present a genome-scale metabolic reconstruction of Pyrococcus furiosus , a well-established platform organism that has been engineered to produce a variety of chemicals and fuels.

Biotechnology & Applied Microbiology↗