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Vandegrift, G. F.

Publications and source records attributed to Vandegrift, G. F..

11 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Irradiation of 20L LEU Uranyl Sulfate Solution for Production of Mo-99

Argonne National Laboratory, with support from the National Nuclear Security Administration’s Office of Material Management and Minimization, is assisting SHINE Medical Technologies in the development of accelerator-driven production of 99 Mo using low-enriched uranium (LEU). Technetium-99m ( 99m Tc), a daughter of 99 Mo, is a workhorse of nuclear medicine, used in approximately 40,000 medical testing procedures each day just in the U.S.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2017

Production of Medical Isotopes with Electron Linacs

Radioisotopes play important roles in numerous areas ranging from medical treatments to national security and basic research. Radionuclide production technology for medical applications has been pursued since the early 1900s both commercially and in nuclear science centers. Many medical isotopes are now in routine production and are used in day-to-day medical procedures. Despite these advancements, research is accelerating around the world to improve the existing production methodologies as well as to develop novel radionuclides for new medical appli-cations. Electron linear accelerators (linacs) represent a unique method for the production of radioisotopes. Even though the basic technology has been around for decades, only recently have electron linacs capable of producing photons with sufficient energy and flux for radioisotope production become available. Housed in Argonne Nation-al Laboratory’s Low Energy Accelerator Facility (LEAF) is a newly upgraded 55 MeV/25-kW electron linear ac-celerator, capable of producing a wide range of radioiso-topes. This talk will focus on the work being performed for the production of the medical isotopes 99Mo (99Mo/99mTc generator), 67Cu, and 47Sc.

Cu-67↗
DOE OSTI2017

Design and Testing of Subsystems for Mo-99 Production

Argonne National Laboratory, in cooperation with Los Alamos National Laboratory, is developing technology with NorthStar Medical Technologies to produce 99 Mo from the γ,n reaction on a 100 Mo target in an electron accelerator. During production runs and thermal testing of the helium-cooled target, it became obvious that a production-scale beam-line configuration would need a collimator to protect the target from accidental beam misplacement or a beam-profile change. A prototype high-power collimator and beam stop were designed and fabricated. Testing indicated that they will be able to operate at full power in the production-scale accelerator.

43 PARTICLE ACCELERATORS↗
DOE OSTI2016

Results of thermal test of metallic molybdenum disk target and fast-acting valve testing

This report describes the irradiation conditions for thermal testing of helium-cooled metallic disk targets that was conducted on March 9, 2016, at the Argonne National Laboratory electron linac. The four disks in this irradiation were pressed and sintered by Oak Ridge National Laboratory from molybdenum metal powder. Two of those disks were instrumented with thermocouples. Also reported are results of testing a fast-acting-valve system, which was designed to protect the accelerator in case of a target-window failure.

36 MATERIALS SCIENCE↗
DOE OSTI2016

Results of four one-day electron-accelerator irradiations of enriched Mo-100 targets for the production of Mo-99

A series of four one-day irradiations was conducted with 100 Mo-enriched disk targets. After irradiation, the enriched disks were removed from the target and dissolved. The resulting solution was processed using a NorthStar RadioGenix™ 99m Tc generator either at Argonne National Laboratory or at the NorthStar Medical Radioisotopes facility. Runs on the RadioGenix system produced inconsistent analytical results for 99m Tc in the Tc/Mo solution. These inconsistencies were attributed to the impurities in the solution or improper column packing. During the irradiations, the performance of the optic transitional radiation (OTR) and infrared cameras was tested in high radiation field. The OTR cameras survived all irradiations, while the IR cameras failed every time. The addition of X-ray and neutron shielding improved camera survivability and decreased the number of upsets.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2016

Accelerator-Driven Production of Fission 99Mo

I{esults al'e reportecl for the procluction of eeMo l'rom the accelerator-clriveu subcritical fission of a low enriohed uranir¡m (Ltju) aqì.reous solution. Phase I ol'these experiments used a 5 L r.rranyl sulfate solution with a eeMo encl-of-irracliation produotion limit of 2 Ci. The separation, recovery, and pulification of eeMo were demonstrated Lrsing the recyclecl solution. Fission product paltitioriing tl'ends will be shown for the recovery colutt'ttt, concentratiorl colurnn, and LE,U Modified Cintichem prooess. The results fi'om a 1.4 Ci oeMo production run, where the fìnal product was seut to GE Flealthcare for testing, will be highlightecl. The information gained cluring Phase ì lias signilìcantly irnpacted the clesign and implernentation of Phase ll. Phase II focuses on an end-of-irradiation ploduction of 20 Ci of eeMo and a fissior'ì power density similar to the production fàcility in a20 L LìlU uranyl sulfate solution.

accelerator↗
DOE OSTI2015

Plant-Scale Concentration Column Designs for SHINE Target Solution Utilizing AG 1 Anion Exchange Resin

Argonne is assisting SHINE Medical Technologies (SHINE) in their efforts to develop SHINE, an accelerator-driven process that will utilize a uranyl-sulfate solution for the production of fission product Mo-99. An integral part of the process is the development of a column for the separation and recovery of Mo-99, followed by a concentration column to reduce the product volume from 15-25 L to <1 L. Argonne has collected data from batch studies and breakthrough column experiments to utilize the VERSE (Versatile Reaction Separation) simulation program (Purdue University) to design plant-scale product recovery and concentration processes.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2015

Micro-Bubble Experiments at the Van de Graaff Accelerator

In order to test and verify the experimental designs at the linear accelerator (LINAC), several micro-scale bubble ("micro-bubble") experiments were conducted with the 3-MeV Van de Graaff (VDG) electron accelerator. The experimental setups included a square quartz tube, sodium bisulfate solution with different concentrations, cooling coils, gas chromatography (GC) system, raster magnets, and two high-resolution cameras that were controlled by a LabVIEW program. Different beam currents were applied in the VDG irradiation. Bubble generation (radiolysis), thermal expansion, thermal convection, and radiation damage were observed in the experiments. Photographs, videos, and gas formation (O 2 + H 2 ) data were collected. The micro-bubble experiments at VDG indicate that the design of the full-scale bubble experiments at the LINAC is reasonable.

43 PARTICLE ACCELERATORS↗