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Wang, Mingyu

Publications and source records attributed to Wang, Mingyu.

9 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2026

Field Evaluation of Do-It-Yourself Air Filtration Solutions for Evaporative Coolers to Reduce Ambient Particle Infiltration in Homes in Wildfire-Affected Communities

Evaporative coolers (ECs) introduce outdoor air pollutants indoors when operating. This study evaluates the potential of do-it-yourself (DIY) air filtration solutions for ECs to cost-effectively reduce the infiltration of ambient fine particulate matter (PM2.5) in homes with ECs using measurements in 48 homes in wildfire-affected agricultural communities in California. All homes received one portable air cleaner (PAC); 25 homes also received DIY filters (mostly MERV 13) attached to their ECs. PurpleAir monitors measured indoor and outdoor PM2.5 concentrations. PAC operation was monitored in all of the homes. EC usage was monitored in some homes and predicted using relative humidity dynamics in all homes. Conditional analyses between EC likely on and off conditions were used to evaluate the impacts of DIY EC filters on ambient PM2.5 infiltration, including during several wildfire-affected days. Median levels of ambient PM2.5 infiltration increased ∼36-42% in homes with only PAC interventions when ECs were likely operating compared to only ∼10-11% in homes with both PACs and DIY EC filters. Pre/postintervention comparisons in a subset of homes confirmed PM2.5 infiltration reductions. EC filter performance declined after extended use. Results suggest that short-term EC filter deployments are likely a cost-effective way to mitigate wildfire smoke infiltration inside these homes.

Wang, Mingyu↗
DOE OSTI2021

Construction of extracellular matrix-based 3D hydrogel and its effects on cardiomyocytes

Highlights: • SOD and Triton X-100 could efficiently decellularize cells to get cardiac ECM. • Main proteins of cECM were fibronectin, collagen, elastin, fibrillin, laminin, etc. • 75% cECM-containing 3D hydrogel promoted cell proliferation and anti-apoptosis. • cECM3DH facilitated the differentiation of ESCs into CMs. • APcECM3DH was more conducive to NCM and ESC-derived CM maturation. Some discoveries resulted from 2-dimensional (2D) cultured cardiac cells have been disqualified in animal testing and later clinical trials. Extracellular matrix (ECM) plays a vital role in cardiac homeostasis, cardiac ECM (cECM)-based 3D cell cultures can mimics the physiological and pathological conditions in vivo closely, it is hopeful of addressing this challenge. Construction of cECM-based 3-dimensional (3D) hydrogel (cECM3DH) and its effects on cell behaviors were studied here. The results indicated that cellular compartments could be efficiently removed from heart tissue via sodium dodecyl sulfonate (SDS)- and Triton X-100-mediated decellularization, remaining the natural fibrous network structure and major proteins. 3D hydrogel consisted of 1 × 10{sup 7} cells/mL cells and 75% cECM could promote the proliferation and anti-apoptosis ability of human embryonic kidney (HEK)-293T cells. 0.25% trypsin or 0.20% collagenase was suitable to retrieve these cells from 3D hydrogel for further researches. Compared with 2D culture system, cECM3DH could significantly increase the proportion of GATA 4{sup +} cardiomyocytes (CMs) derived from heart tissue of neonatal mouse or induced differentiation of embryonic stem cells (ESCs) (P < 0.05) The expression levels of mature genes including cTnT, JCN, CaV1.2, MYL2, CASQ2, NCX1, and Cx43 of these CMs in adult pig cECM-based 3D hydrogel (APcECM3DH) were significantly higher than that in 2D culture system and in newborn piglet cECM-based 3D hydrogel (NPcECM3DH), respectively (P < 0.05). Therefore, cECM3DH supports the generation of primary CMs and ESC-derived CMs, APcECM3DH was more conducive to promoting CM maturation, which contributes to building 3D model for pathogenesis exploration, drug screening, and regenerative medicine of heart diseases.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Multi-mode cabin heating system with dual heating source

A heating system for an automotive passenger cabin includes a blower fan generating an air flow; a first heater core downstream of the blower fan; a second heater core downstream of the first heater core; a coolant loop with a first branch and a second branch, wherein the first heater core is disposed in the first branch and the second heater core is disposed in the second branch; a change-over valve arrangement having a first setting establishing fluid communication between the first and second heater cores by connecting the first and second branches in two locations on opposite sides of the first and second heater cores. The change-over valve arrangement has a second setting separating the fluid communication between the first and second heater cores by disconnecting the first and second branches. The second branch or both the first and the second branch are connectable to a PCM heater.

42 ENGINEERING↗
DOE OSTI2017

A Ferredoxin- and F 420 H 2 -Dependent, Electron-Bifurcating, Heterodisulfide Reductase with Homologs in the Domains Bacteria and Archaea

ABSTRACT Heterodisulfide reductases (Hdr) of the HdrABC class are ancient enzymes and a component of the anaerobic core belonging to the prokaryotic common ancestor. The ancient origin is consistent with the widespread occurrence of genes encoding putative HdrABC homologs in metabolically diverse prokaryotes predicting diverse physiological functions; however, only one HdrABC has been characterized and that was from a narrow metabolic group of obligate CO 2 -reducing methanogenic anaerobes (methanogens) from the domain Archaea . Here we report the biochemical characterization of an HdrABC homolog (HdrA2B2C2) from the acetate-utilizing methanogen Methanosarcina acetivorans with unusual properties structurally and functionally distinct from the only other HdrABC characterized. Homologs of the HdrA2B2C2 archetype are present in phylogenetically and metabolically diverse species from the domains Bacteria and Archaea . The expression of the individual HdrA2, HdrB2, and HdrB2C2 enzymes in Escherichia coli , and reconstitution of an active HdrA2B2C2 complex, revealed an intersubunit electron transport pathway dependent on ferredoxin or coenzyme F 420 (F 420 H 2 ) as an electron donor. Remarkably, HdrA2B2C2 couples the previously unknown endergonic oxidation of F 420 H 2 and reduction of ferredoxin with the exergonic oxidation of F 420 H 2 and reduction of the heterodisulfide of coenzyme M and coenzyme B (CoMS-SCoB). The unique electron bifurcation predicts a role for HdrA2B2C2 in Fe(III)-dependent anaerobic methane oxidation (ANME) by M. acetivorans and uncultured species from ANME environments. HdrA2B2C2, ubiquitous in acetotrophic methanogens, was shown to participate in electron transfer during acetotrophic growth of M. acetivorans and proposed to be essential for growth in the environment when acetate is limiting. IMPORTANCE Discovery of the archetype HdrA2B2C2 heterodisulfide reductase with categorically unique properties extends the understanding of this ancient family beyond CO 2 -reducing methanogens to include diverse prokaryotes from the domains Bacteria and Archaea . The unprecedented coenzyme F 420 -dependent electron bifurcation, an emerging fundamental principle of energy conservation, predicts a role for HdrA2B2C2 in diverse metabolisms, including anaerobic CH 4 -oxidizing pathways. The results document an electron transport role for HdrA2B2C2 in acetate-utilizing methanogens responsible for at least two-thirds of the methane produced in Earth’s biosphere. The previously unavailable heterologous production of individual subunits and the reconstitution of HdrA2B2C2 with activity have provided an understanding of intersubunit electron transfer in the HdrABC class and a platform for investigating the principles of electron bifurcation.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2017

Integration and Validation of a Thermal Energy Storage System for Electric Vehicle Cabin Heating

It is widely recognized in the automotive industry that, in very cold climatic conditions, the driving range of an Electric Vehicle (EV) can be reduced by 50% or more. In an effort to minimize the EV range penalty, a novel thermal energy storage system has been designed to provide cabin heating in EVs and Plug-in Hybrid Electric Vehicles (PHEVs) by using an advanced phase change material (PCM). This system is known as the Electrical PCM-based Thermal Heating System (ePATHS) [1, 2]. When the EV is connected to the electric grid to charge its traction battery, the ePATHS system is also “charged” with thermal energy. The stored heat is subsequently deployed for cabin comfort heating during driving, for example during commuting to and from work.The ePATHS system, especially the PCM heat exchanger component, has gone through substantial redesign in order to meet functionality and commercialization requirements. The final system development for EV implementation has occurred on a mid-range EV and has been evaluated for its capability to extend the driving range. Both simulated driving in a climatic tunnel and actual road testing have been carried out. The ePATHS has demonstrated its ability to supply the entire cabin heating needs for a round trip commute totaling 46 minutes, including 8 hours of parking, at an ambient temperature of -10°C.

Wang, Mingyu↗
DOE OSTI2016

System and method of providing quick thermal comfort with reduced energy by using directed spot conditioning

A heating, ventilation, and air conditioning (HVAC) system and a method of controlling a HVAC system that is configured to provide a perceived comfortable ambient environment to an occupant seated in a vehicle cabin. The system includes a nozzle configured to direct an air stream from the HVAC system to the location of a thermally sensitive portion of the body of the occupant. The system also includes a controller configured to determine an air stream temperature and an air stream flow rate necessary to establish the desired heat supply rate for the sensitive portion and provide a comfortable thermal environment by thermally isolating the occupant from the ambient vehicle cabin temperature. The system may include a sensor to determine the location of the sensitive portion. The nozzle may include a thermoelectric device to heat or cool the air stream.

33 ADVANCED PROPULSION SYSTEMS↗
DOE OSTI2016

Thermal Storage System for Electric Vehicle Cabin Heating Component and System Analysis

Cabin heating of current electric vehicle (EV) designs is typically provided using electrical energy from the traction battery, since waste heat is not available from an engine as in the case of a conventional automobile. In very cold climatic conditions, the power required for space heating of an EV can be of a similar magnitude to that required for propulsion of the vehicle. As a result, its driving range can be reduced very significantly during the winter season, which limits consumer acceptance of EVs and results in increased battery costs to achieve a minimum range while ensuring comfort to the EV driver. To minimize the range penalty associated with EV cabin heating, a novel climate control system that includes thermal energy storage from an advanced phase change material (PCM) has been designed for use in EVs and plug-in hybrid electric vehicles (PHEVs). The present paper focuses on the modeling and analysis of this electrical PCM-Assisted Thermal Heating System (ePATHS) and is a companion to the paper Design and Testing of a Thermal Storage System for Electric Vehicle Cabin Heating. A detailed heat transfer model was developed to simulate the PCM heat exchanger that is at the heart of the ePATHS and was subsequently used to analyze and optimize its design. The results from this analysis were integrated into a MATLAB Simulink system model to simulate the fluid flow, pressure drop and heat transfer in all components of the ePATHS. The system model was then used to predict the performance of the climate control system in the vehicle and to evaluate control strategies needed to achieve the desired temperature control in the cabin. The analysis performed to design the ePATHS is described in detail and the system s predicted performance in a vehicle HVAC system is presented.

cabin heating↗
DOE OSTI2016

Design and Testing of a Thermal Storage System for Electric Vehicle Cabin Heating

Without the waste heat available from the engine of a conventional automobile, electric vehicles (EVs) must provide heat to the cabin for climate control using energy stored in the vehicle. In current EV designs, this energy is typically provided by the traction battery. In very cold climatic conditions, the power required to heat the EV cabin can be of a similar magnitude to that required for propulsion of the vehicle. As a result, the driving range of an EV can be reduced very significantly during winter months, which limits consumer acceptance of EVs and results in increased battery costs to achieve a minimum range while ensuring comfort to the EV driver. To minimize the range penalty associated with EV cabin heating, a novel climate control system that includes thermal energy storage has been designed for use in EVs and plug-in hybrid electric vehicles (PHEVs). The system uses the stored latent heat of an advanced phase change material (PCM) to provide cabin heating. The PCM is melted while the EV is connected to the electric grid for charging of the electric battery, and the stored energy is subsequently transferred to the cabin during driving. To minimize thermal losses when the EV is parked for extended periods, the PCM is encased in a high performance insulation system. The electrical PCM-Assisted Thermal Heating System (ePATHS) was designed to provide enough thermal energy to heat the EV s cabin for approximately 46 minutes, covering the entire daily commute of a typical driver in the U.S.

electric vehicles↗