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Warren, H.

Publications and source records attributed to Warren, H..

8 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation

Abstract Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species. After LPS stimulation, maximally different genes in resilient species included genes that detoxify LPS, diminish bacterial growth, discriminate sepsis from SIRS, and play roles in autophagy and apoptosis. The findings reveal the molecular landscape of species differences in inflammation. This may inform better selection of species for pre-clinical models and could lead to new therapeutic strategies that mimic mechanisms in inflammation-resilient species to limit inflammation without causing immunosuppression.

Biochemistry & Molecular Biology↗
NASA NTRS2010

Extreme Ultraviolet Variability Experiment (EVE) on the Solar Dynamics Observatory (SDO): Overview of Science Objectives, Instrument Design, Data Products, and Model Developments

The highly variable solar extreme ultraviolet (EUV) radiation is the major energy input to the Earth's upper atmosphere, strongly impacting the geospace environment, affecting satellite operations, communications, and navigation. The Extreme ultraviolet Variability Experiment (EVE) onboard the NASA Solar Dynamics Observatory (SDO) will measure the solar EUV irradiance from 0.1 to 105 nm with unprecedented spectral resolution (0.1 nm), temporal cadence (ten seconds), and accuracy (20%). EVE includes several irradiance instruments: The Multiple EUV Grating Spectrographs (MEGS)-A is a grazingincidence spectrograph that measures the solar EUV irradiance in the 5 to 37 nm range with 0.1-nm resolution, and the MEGS-B is a normal-incidence, dual-pass spectrograph that measures the solar EUV irradiance in the 35 to 105 nm range with 0.1-nm resolution. To provide MEGS in-flight calibration, the EUV SpectroPhotometer (ESP) measures the solar EUV irradiance in broadbands between 0.1 and 39 nm, and a MEGS-Photometer measures the Sun s bright hydrogen emission at 121.6 nm. The EVE data products include a near real-time space-weather product (Level 0C), which provides the solar EUV irradiance in specific bands and also spectra in 0.1-nm intervals with a cadence of one minute and with a time delay of less than 15 minutes. The EVE higher-level products are Level 2 with the solar EUV irradiance at higher time cadence (0.25 seconds for photometers and ten seconds for spectrographs) and Level 3 with averages of the solar irradiance over a day and over each one-hour period. The EVE team also plans to advance existing models of solar EUV irradiance and to operationally use the EVE measurements in models of Earth s ionosphere and thermosphere. Improved understanding of the evolution of solar flares and extending the various models to incorporate solar flare events are high priorities for the EVE team.

Woods, T. N.↗
NASA NTRS1985

International time transfer and portable clock evaluation using GPS timing receivers: Preliminary results

The overall experiment was designed to test the positioning and navigation capabilities of the GPS timing receivers developed by the Naval Research Laboratory (NRL) for the NASA Goddard Laser Tracking Network (GITN). To perform this experiment, a reliable and redundant time scale was set up onboard the ship, and a back-up on shore. This situation provided the opportunity to perform simultaneously a timing experiment ideally divided into two parts, the main objectives of the experimentation being: (1) To test GPS timing receiver synchronization capabilities on a moving platform, and to perform an intercontinental synchronization via GPS between participating international timing laboratories in Europe and in the United States. (2) To evaluate the performance of cesium portable clocks in the field.

Wardrip, S. C.↗
NASA NTRS1982

Global Positioning System Time Transfer Receiver (GPS/TTR) prototype design and initial test evaluation

Time transfer equipment and techniques used with the Navigation Technology Satellites were modified and extended for use with the Global Positioning System (GPS) satellites. A prototype receiver was built and field tested. The receiver uses the GPS L1 link at 1575 MHz with C/A code only to resolve a measured range to the satellite. A theoretical range is computed from the satellite ephemeris transmitted in the data message and the user's coordinates. Results of user offset from GPS time are obtained by differencing the measured and theoretical ranges and applying calibration corrections. Results of the first field test evaluation of the receiver are presented.

Oaks, J.↗
NASA NTRS1979

Submicrosecond comparison of international clock synchronization by VLBI and the NTS satellite

The intercontinental clock synchronization capabilities of Very Long Baseline Interferometry (VLBI) and the Navigation Technology Satellite (NTS) were compared using both methods to synchronize the Cesium clocks at the NASA Deep Space Net complexes at Madrid, Spain and Goldstone, California. Verification of the accuracy of both systems was examined. The VLBI experiments used the Wideband VLBI Data Acquisition System developed at the NASA Jet Propulsion Laboratory. The NTS Satellites were designed and built by the Naval Research Laboratory used with NTS Timing Receivers developed by the Goddard Space Flight Center. The two methods agreed at about the one-half microsecond level.

Hurd, W. J.↗
NASA NTRS1979

Submicrosecond comparison of intercontinental clock synchronization by VLBI and the NTS satellite

The intercontinental clock synchronization capabilities of Very Long Baseline Interferometry (VLBI) and the Navigation Technology Satellite (NTS) were compared in May 1978 by using both methods to synchronize the cesium clocks at the NASA Deep Space Net complexes at Madrid, Spain, and Goldstone, California. The VLBI experiments used the Wideband VLBI Data Acquisition System. The Navigation Technology Satellites were used with NTS Timing Receivers developed by the Goddard Space Flight Center. The two methods agreed at about the one-half microsecond level. The VLBI system also obtained long-term stability information on the HP5061A004 cesium standards by measuring delta T/T over four 3- to 4-day intervals, obtaining stability estimates of (1 + or - 1)x10 to the -13th power for the combined timing systems.

Hurd, W. J.↗