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Williams, Jessica

Publications and source records attributed to Williams, Jessica.

6 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (TOP2) mediated DNA damages and causes cellular resistance to clinically used TOP2 poisons. Inhibiting TDP2 can potentially sensitize cancer cells toward TOP2 poisons. Commercial compound P10A10, to which the structure was assigned as 7-phenyl triazolopyrimidine analogue 6a, was previously identified as a TDP2 inhibitor hit in our virtual and fluorescence-based biochemical screening campaign. In this artilce, we report that the hit validation through resynthesis and structure elucidation revealed the correct structure of P10A10 (Chembridge ID 7236827) to be the 5-phenyl triazolopyrimidine regioisomer 7a. Subsequent structure–activity relationship (SAR) via the synthesis of a total of 47 analogues of both the 5-phenyl triazolopyrimidine scaffold (7) and its bioisosteric triazolopyridine scaffold (17) identified four derivatives (7a, 17a, 17e, and 17z) with significant TDP2 inhibition (IC 50 < 50 μM), with 17z showing excellent cell permeability and no cytotoxicity.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2017

Navigation automation for the Soil Moisture Active Passive observatory

Soil Moisture Active Passive (SMAP) is a NASA Earth science mission designed to measure soil moisture content and freeze/thaw cycles over a three-year period. This paper presents a 2-year summary of navigation performance, shows navigation compliance (and non-compliance) with Science Orbit Requirements, and describes how automated processes appreciably reduced the size of the navigation team.

Lee, Julim↗
NASA NTRS2016

Solar Probe Plus: Unique Navigation Modeling Challenges

The Solar Probe Plus (SPP) mission is preparing to launch in 2018, and will directly investigate the outer atmosphere of our star. At 9.86 solar radii, SPP must operate in an unexplored regime. The environment and aspects of the mission design present some unique challenges for navigation, particularly in terms of modeling the dynamics. Non-gravitational force models, unique to this mission, are given with analytical expressions. For each of these models (and error sources), a maximum bound on the force perturbation magnitude is quantified numerically. Additionally, the effect of charged particles on radiometric observables is discussed, along with methods being employed to pre-process the measurements. This survey is an overview of unique modeling employed by SPP navigation, but also a reference for future missions traveling near the Sun.

Jones, Drew Ryan↗
NASA NTRS2016

Final Mission and Navigation Design for the 2016 Mars InSight Mission

NASA’s Interior Exploration using Seismic Investigations, Geodesy, and Heat Transport (InSight) mission was scheduled to launch the next lander to Mars in March 2016 arriving to the Red Planet in the fall. Derived from the Phoenix mission which successfully landed on Mars in May 2008, the InSight Entry, Descent, and Landing system will place a lander in the Elysium Planitia region. This paper specifies the mission and navigation requirements set by the Project and how the final mission and navigation design satisfies those requirements. Background information affecting navigation including spacecraft modeling and the physical environment which influences the spacecraft motion are included. (Note from the author: The InSight launch in 2016 was suspended due to critical issues with the Seismic Experiment for Interior Structure (SEIS) instrument that could not be fixed prior to the planned launch period. This paper represents the state of the design for the 2016 mission. No attempt has been made to reflect the latest developments).

Abilleira, Fernando↗
NASA NTRS2013

Recent Climate and Ice-Sheet Changes in West Antarctica Compared with the Past 2,000 Years

Changes in atmospheric circulation over the past five decades have enhanced the wind-driven inflow of warm ocean water onto the Antarctic continental shelf, where it melts ice shelves from below1-3. Atmospheric circulation changes have also caused rapid warming4 over the West Antarctic Ice Sheet, and contributed to declining sea-ice cover in the adjacent Amundsen-Bellingshausen seas5. It is unknown whether these changes are part of a longer-term trend. Here, we use waterisotope (Delta O-18) data from an array of ice-core records to place recent West Antarctic climate changes in the context of the past two millennia. We find that the δ18O of West Antarctic precipitation has increased significantly in the past 50 years, in parallel with the trend in temperature, and was probably more elevated during the 1990s than at any other time during the past 200 years. However, Delta O-18 anomalies comparable to those of recent decades occur about 1% of the time over the past 2,000 years. General circulation model simulations suggest that recent trends in Delta O-18 and climate in West Antarctica cannot be distinguished from decadal variability that originates in the tropics. We conclude that the uncertain trajectory of tropical climate variability represents a significant source of uncertainty in projections of West Antarctic climate and ice-sheet change.

Ice-sheet↗