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Williams, T. E.

Publications and source records attributed to Williams, T. E..

System for and method of freezing biological tissue

Biological tissue is frozen while a polyethylene bag placed in abutting relationship against opposed walls of a pair of heaters. The bag and tissue are cooled with refrigerating gas at a time programmed rate at least equal to the maximum cooling rate needed at any time during the freezing process. The temperature of the bag, and hence of the tissue, is compared with a time programmed desired value for the tissue temperature to derive an error indication. The heater is activated in response to the error indication so that the temperature of the tissue follows the desired value for the time programmed tissue temperature. The tissue is heated to compensate for excessive cooling of the tissue as a result of the cooling by the refrigerating gas. In response to the error signal, the heater is deactivated while the latent heat of fusion is being removed from the tissue while the tissue is changing phase from liquid to solid.

Williams, T. E.↗

Controlled freezing of biological samples

Apparatus consists of thermocouple connected to semiconductor reference junction. Junction is connected to amplifier that boosts signal by 1,000. High-level signal is displayed on recorder and fed into second amplifier where it is compared with signal from potentiometer of programmed dc reference in bag-temperature programer. Difference in signals indicates output voltage. Remaining circuitry provides zero-phase, time-proportion control of heaters such that heater power is directly proportional to error signal.

Cygnarowicz, T. A.↗

Design of a blood-freezing system for leukemia research

Leukemia research involves the use of cryogenic freezing and storage equipment. In a program being carried out at the National Cancer Institute (NCI), bone marrow (white blood cells) was frozen using a standard cryogenic biological freezer. With this system, it is difficult to maintain the desired rate of freezing and repeatability from sample to sample. A freezing system was developed that satisfies the requirements for a repeatable, constant freezing rate. The system was delivered to NIC and is now operational. This report describes the design of the major subsystems, the analyses, the operating procedure, and final system test results.

Williams, T. E.↗

Pulsed plasma microthruster for synchronous meteorological satellite /SMS/

Two completely self contained variable thrust flight prototype plasma propulsion systems using solid teflon as propellant were designed, built and laboratory tested. The impulse bit amplitude of each thruster is 25 micro lb-sec. Impulse bits can be provided at rates varying from 50 ppm to 110 ppm. The total impulse capability is 400 lb-sec. Only 23 watts of bus power are required at maximum pulse rate. The system was subjected and passed the required vibration schedule and thermal vacuum test after a minor change in capacitor end face material. A 13 million discharge life test of the system was subsequently performed.

Guman, W. J.↗

Performance testing of a solid propellant pulsed plasma microthruster.

Extensive performance testing has been carried out on a solid propellant, pulsed plasma microthruster essentially identical to the four units aboard the DOD, Lincoln Experimental Satellite (LES)-6. Tests include measurements of thrust, specific impulse, thrust vector, impulse bit repeatability, intermittency and endurance. The results show good impulse bit repeatability and a well defined thrust vector. The impulse bit, with a 1.85-joule input, was found to be approximately 26 micronewton-seconds at 190 seconds specific impulse. Based upon the results of the intermittency tests, a better understanding of the intermittency mechanism has been achieved.

Williams, T. E.↗