Engineering topics

Ying Chen

Publications and source records attributed to Ying Chen.

4 records

NASA NTRS2026

Global Model Estimates of Atmospheric Al, Ca, Fe, Si, and Ti from Dust and Non-Dust Aerosols Informed by EMIT Surface Mineralogy and Evaluated Against Observations

Atmospheric deposition of micro-nutrients like Fe has been shown to be important for ocean biogeochemistry. The largest source of atmospheric Fe and other elements (e.g., Ca, Al, Si, and Ti) is desert dust, although there are significant non-dust sources in some regions. However, past estimates of these elements have been substantially uncertain due to limited information about the composition of the desert source regions. Here we use elemental distributions estimated from new Earth Surface Mineral Dust Source Investigation (EMIT) observations, which provide mineralogical composition at the surface of the Earth based on imaging spectroscopy measurements from the International Space Station. We add in other sources of these elements (anthropogenic and natural) and compare to a compilation of available surface concentration data from stations over land and from shipborne observations. Our results suggest that the modeled distribution is similar to available observations, but discrepancies still exist in both natural desert dust regions as well as regions dominated by anthropogenic sources. Global budgets for the elements Ca, Al, Fe, Si, and Ti suggest that desert dust remains the dominant source for these elements but anthropogenic or volcanic sources are also important for these elements. Changes in elemental distributions since preindustrial times were also estimated.

aerosols↗

NASA NTRS2024

Substantial Cooling Effect From Aerosol-Induced Increase in Tropical Marine Cloud Cover

With global warming currently standing at approximately +1.2 °C since preindustrial times, climate change is a pressing global issue. Marine cloud brightening is one proposed method to tackle warming through injecting aerosols into marine clouds to enhance their reflectivity and thereby planetary albedo. However, because it is unclear how aerosols influence clouds, especially cloud cover, both climate projections and the effectiveness of marine cloud brightening remain uncertain. Here, we use satellite observations of volcanic eruptions in Hawaii to quantify the aerosol fingerprint on tropical marine clouds. We observe a large enhancement in reflected sunlight, mainly due to an aerosol-induced increase in cloud cover. This observed strong negative aerosol forcing suggests that the current level of global warming is driven by a weaker net radiative forcing than previously thought, arising from the competing effects of greenhouse gases and aerosols. This implies a greater sensitivity of Earth’s climate to radiative forcing and therefore a larger warming response to both rising greenhouse gas concentrations and reductions in atmospheric aerosols due to air quality measures. However, our findings also indicate that mitigation of global warming via marine cloud brightening is plausible and is most effective in humid and stable conditions in the tropics where solar radiation is strong.

Atmospheric science↗

NASA NTRS2022

Machine-Learning Reveals Climate Forcing From Aerosols is Dominated by Increased Cloud Cover

Aerosol-cloud interactions have a potentially large impact on climate, but are poorly quantified and thus contribute a significant and long-standing uncertainty in climate projections. The impacts derived from climate models are poorly constrained by observations, because retrieving robust large-scale signals of aerosol-cloud interactions are frequently hampered by the considerable noise associated with meteorological co-variability. The Iceland-Holuhraun effusive eruption in 2014 resulted in a massive aerosol plume in an otherwise near-pristine environment and thus provided an ideal natural experiment to quantify cloud responses to aerosol perturbations. Here we disentangle significant signals from the noise of meteorological co-variability using a satellite-based machine-learning approach. Our analysis shows that aerosols from the eruption increased cloud cover by approximately 10%, and this appears to be the leading cause of climate forcing, rather than cloud brightening as previously thought. We find that volcanic aerosols do brighten clouds by reducing droplet size, but this has a significantly smaller radiative impact than changes in cloud fraction. These results add substantial observational constraints on the cooling impact of aerosols. Such constraints are critical for improving climate models, which still inadequately represent the complex macro-physical and micro-physical impacts of aerosol-cloud interactions.

Aerosols↗

NASA NTRS2021

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers, are associated with nucleotide metabolic dysfunction in lymphoma. The results from our experiments showed that ribonucleotide and deoxyribonucleotide pool depletion, suppression of global RNA/DNA synthesis, and cell cycle inhibition occurred in the presence of FASN inhibition. Subsequently, we observed that FASN inhibition caused metabolic blockade in the rate-limiting step of the oxidative branch of the pentose phosphate pathway (oxPPP) catalyzed by phosphogluconate dehydrogenase (PGDH). Furthermore, we determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH. Through cell-free enzyme assays consisting of FASN and PGDH, we delineated that the PGDH-catalyzed ribulose-5-phosphate synthesis is enhanced in the presence of FASN and is suppressed by increasing concentrations of NADPH. Additionally, we observed that FASN and PGDH were colocalized in the cytosol. The results from these experiments led us to conclude that NADP–NADPH turnover and the reciprocal stimulation of FASN and PGDH catalysis are involved in promoting oxPPP and nucleotide biosynthesis in lymphoma. Finally, a transcriptomic analysis of non-Hodgkin’s lymphoma (n = 624) revealed the increased expression of genes associated with metabolic functions interlinked with oxPPP, while the expression of genes participating in oxPPP remained unaltered. Together we conclude that FASN–PGDH enzymatic interactions are involved in enabling oxPPP and nucleotide metabolic dysfunction in lymphoma tumors.

Non-Hodgkin lymphoma↗